Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physics, Applied
Maksudbek Yusupov, Debbie Dewaele, Pankaj Attri, Umedjon Khalilov, Frank Sobott, Annemie Bogaerts
Summary: This study unravels the possible mechanisms of oligosaccharide oxidation induced by cold atmospheric plasma (CAP), providing atomic-level insight into the onset of plasma-induced removal of biofilms.
PLASMA PROCESSES AND POLYMERS
(2023)
Review
Multidisciplinary Sciences
Neha Kaushik, Sarmistha Mitra, Eun Jung Baek, Linh Nhat Nguyen, Pradeep Bhartiya, June Hyun Kim, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: This review critically examines methods for generating reactive oxygen species (ROS) and explores their potential as a solution for virus deactivation. The study highlights the ability of ROS to directly eradicate pathogens through oxidative stress and indirectly through non-oxidative mechanisms. Additionally, the novel and environmentally friendly cold plasma delivery system for virus destruction is discussed in detail.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Review
Chemistry, Multidisciplinary
Dayun Yan, Alisa Malyavko, Qihui Wang, Li Lin, Jonathan H. Sherman, Michael Keidar
Summary: Cold atmospheric plasma (CAP) is an ionized gas generated by non-equilibrium discharge at atmospheric conditions, showing unique biological impacts in cancer treatment. With potential clinical applications, CAP cancer treatment can utilize both chemical and physical approaches for therapeutic benefits.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Yuma Suenaga, Toshihiro Takamatsu, Toshiki Aizawa, Shohei Moriya, Yuriko Matsumura, Atsuo Iwasawa, Akitoshi Okino
Summary: The study found that nitrogen plasma produced a higher concentration of OH radicals, while the concentration of singlet oxygen in carbon dioxide plasma increased with gas temperature. The bactericidal ability of carbon dioxide plasma increased with gas temperature, while nitrogen plasma did not exhibit a high bactericidal effect.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Applied
M. Dharini, S. Jaspi, R. Mahendran
Summary: Cold plasma, generated at room temperature, consists of reactive species that cause chemical and physical changes in biological materials. Its applications in food aim to ensure safety, quality, and property modification. However, our understanding of the mechanisms behind these alterations is limited, with only a few reactive oxygen and nitrogen species being extensively studied. This review explores the use of different feed gases to modify species composition and highlights the importance of considering all reactive species in food modification, along with the potential of molecular dynamics simulation to bridge the knowledge gap.
Article
Agriculture, Multidisciplinary
Shaimaa Hatab, John K. Koddy, Wenhua Miao, Lingling Tang, Huiqian Xu, Shanggui Deng, Bin Zheng
Summary: The study found that treating hairtail fish with ACP led to slight changes in peroxide value and thiobarbituric acid reactive substances, but significant increases in surface hydrophobicity, turbidity, and water-holding capacity. This indicates that ACP treatment can enhance the protein and lipid properties of hairtail fish myofibril protein, reinforcing gel formation.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Catarina Almeida-Ferreira, Rafael Silva-Teixeira, Ana Cristina Goncalves, Carlos Miguel Marto, Ana Bela Sarmento-Ribeiro, Francisco Caramelo, Maria Filomena Botelho, Mafalda Laranjo
Summary: This study evaluated the therapeutic potential of cold atmospheric plasma (CAP) in breast cancer cells with distinct histological features and found that apoptosis was the most prevalent type of cell death. In addition, CAP treatment inhibited cell replication ability and antioxidative activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sun-Ja Kim, Min-Jeong Seong, Jong-Jin Mun, Jin-Hee Bae, Hea-Min Joh, Tae-Hun Chung
Summary: This study compared the effects of cold atmospheric plasma (CAP) on non-cancerous and melanoma cells. The results showed that melanoma cells were more sensitive to CAP treatment and produced more reactive oxygen and nitrogen species (RONS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Helena Motaln, Nina Recek, Boris Rogelj
Summary: This review examines the potential use of cold atmospheric plasma in medicine, particularly its beneficial effects on tumor reduction in oncology. It discusses the cellular changes and impacts on main cellular processes, such as proliferation, migration, protein degradation, and various forms of cell death, especially in the oncology field of plasma medicine.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Engineering, Chemical
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: Cold atmospheric pressure plasmas (CAPPs) have attracted increasing attention in the field of medicine, particularly in oncology. The selective anticancer characteristics of CAPP make it a promising application for treating skin cancers. Research on the effects of CAPP on skin cancers has provided insights into potential new treatments and the complex interactions between reactive species and cellular components.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Article
Environmental Sciences
Dongjie Cui, Yue Yin, Hao Sun, Xiaojie Wang, Jie Zhuang, Lin Wang, Ruonan Ma, Zhen Jiao
Summary: Atmospheric pressure cold plasma (APCP) has great potential in improving crop production. This study investigates the regulation mechanism of APCP-generated reactive oxygen and nitrogen species (RONS) on intracellular redox homeostasis and plant growth. The results demonstrate that APCP treatment has a dual effect on Arabidopsis seedling growth, depending on the treatment time. APCP treatment leads to an increase in RONS in the liquid, conductivity, and oxidation reduction potential, and a decrease in pH. APCP treatment also causes an enrichment of intracellular RONS and an increase in malondialdehyde generation. Low-dose APCP treatment enhances intracellular antioxidants while high doses decrease their levels. These results highlight the importance of improved antioxidant capacity induced by moderate APCP-generated RONS in promoting plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.