On the nature of the optimal form of the holdase‐type chaperone stress response

Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins

(2019) Axel Mogk et al.   Annual Review of Microbiology

Targeting hsp90 family members: A strategy to improve cancer cell death

(2019) Pedro Buc Calderon et al.   BIOCHEMICAL PHARMACOLOGY

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein–Protein Interactions in the Molecular Chaperone Network

(2018) Rebecca Freilich et al.   ACCOUNTS OF CHEMICAL RESEARCH

A new look at an old view of denaturant induced protein unfolding

(2018) Damien Hall et al.   ANALYTICAL BIOCHEMISTRY

Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding

(2018) Unekwu M. Yakubu et al.   BIOLOGICAL CHEMISTRY

Exploring the Denatured State Ensemble by Single-Molecule Chemo-Mechanical Unfolding: The Effect of Force, Temperature, and Urea

(2018) Emily J. Guinn et al.   JOURNAL OF MOLECULAR BIOLOGY

A biosensor-based framework to measure latent proteostasis capacity

(2018) Rebecca J. Wood et al.   Nature Communications

Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer’s disease

(2018) Alfonso Martín-Peña et al.   Scientific Reports

Oligomerization of a molecular chaperone modulates its activity

(2018) Tomohide Saio et al.   eLife

Aging and Proteins: What Does Proteostasis Have to Do with Age?

(2018) S. Magalhaes et al.   CURRENT MOLECULAR MEDICINE

It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate

(2018) Indu Santhanagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small heat shock proteins: Simplicity meets complexity

(2018) Martin Haslbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin-dependent aggregation of hen egg white lysozyme reveals two distinct mechanisms of amyloid fibrillation

(2017) Ayame Nitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Ligand-promoted protein folding by biased kinetic partitioning

(2017) Karan S Hingorani et al.   Nature Chemical Biology

Stress-Activated Chaperones: A First Line of Defense

(2017) Wilhelm Voth et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recognizing and analyzing variability in amyloid formation kinetics: Simulation and statistical methods

(2016) Damien Hall et al.   ANALYTICAL BIOCHEMISTRY

Protein aggregate turbidity: Simulation of turbidity profiles for mixed-aggregation reactions

(2016) Damien Hall et al.   ANALYTICAL BIOCHEMISTRY

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

(2016) Ye Jin Chai et al.   JOURNAL OF CELL BIOLOGY

Incorporation of Hard and Soft Protein–Protein Interactions into Models for Crowding Effects in Binary and Ternary Protein Mixtures. Comparison of Approximate Analytical Solutions with Numerical Simulation

(2016) Travis Hoppe et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Absolute protein quantification of the yeast chaperome under conditions of heat shock

(2016) Rebecca J. Mackenzie et al.   PROTEOMICS

The GroEL–GroES Chaperonin Machine: A Nano-Cage for Protein Folding

(2016) Manajit Hayer-Hartl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy)

(2015) Younhee Cho et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs

(2015) Andrija Finka et al.   CELL STRESS & CHAPERONES

A multi-pathway perspective on protein aggregation: Implications for control of the rate and extent of amyloid formation

(2015) Damien Hall et al.   FEBS LETTERS

The Mechanism and Function of Group II Chaperonins

(2015) Tom Lopez et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chemical Biology of Molecular Chaperones—Implications for Modulation of Proteostasis

(2015) Kristoffer R. Brandvold et al.   JOURNAL OF MOLECULAR BIOLOGY

Expression profiles of heat shock protein 27 and αB-crystallin and their effects on heat-stressed rat myocardial cells in vitro and in vivo

(2015) SHU TANG et al.   Molecular Medicine Reports

A Novel Mechanism for Small Heat Shock Proteins to Function as Molecular Chaperones

(2015) Kaiming Zhang et al.   Scientific Reports

Individual and Collective Contributions of Chaperoning and Degradation to Protein Homeostasis in E. coli

(2015) Younhee Cho et al.   Cell Reports

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Molecular Chaperones in Cellular Protein Folding: The Birth of a Field

(2014) Arthur L. Horwich   CELL

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Differential Expression of Heat Shock Transcription Factors and Heat Shock Proteins after Acute and Chronic Heat Stress in Laying Chickens (Gallus gallus)

(2014) Jingjing Xie et al.   PLoS One

What is the total number of protein molecules per cell volume? A call to rethink some published values

(2013) Ron Milo   BIOESSAYS

Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis

(2013) Andrija Finka et al.   CELL STRESS & CHAPERONES

Serum Albumin Prevents Protein Aggregation and Amyloid Formation and Retains Chaperone-like Activity in the Presence of Physiological Ligands

(2012) Thomas E. Finn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation and elimination of yeast prions by protein chaperones and co-chaperones.

(2012) Michael Reidy et al.   Prion

Global analysis of chaperone effects using a reconstituted cell-free translation system

(2012) T. Niwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoldEco: A Model for Proteostasis in E. coli

(2012) Evan T. Powers et al.   Cell Reports

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Effect of Lipid Type on the Binding of Lipid Vesicles to Islet Amyloid Polypeptide Amyloid Fibrils

(2010) Kenji Sasahara et al.   BIOCHEMISTRY

Balance between Folding and Degradation for Hsp90-Dependent Client Proteins: A Key Role for CHIP

(2010) Lenka Kundrat et al.   BIOCHEMISTRY

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation

(2010) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model of amyloid's role in disease based on fibril fracture

(2009) Damien Hall et al.   BIOPHYSICAL CHEMISTRY

Disaggregating Chaperones: An Unfolding Story

(2009) Sandeep Sharma et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Stabilization of multimeric enzymes: Strategies to prevent subunit dissociation

(2009) Roberto Fernandez-Lafuente   ENZYME AND MICROBIAL TECHNOLOGY

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

The eye lens chaperone  -crystallin forms defined globular assemblies

(2009) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The weighted sum method for multi-objective optimization: new insights

(2009) R. Timothy Marler et al.   STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION

Multi-scale modelling of amyloid formation from unfolded proteins using a set of theory derived rate constants

(2008) Damien Hall et al.   BIOPHYSICAL CHEMISTRY

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

(2008) Zhen Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY