An overview of late-stage functionalization in today’s drug discovery
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An overview of late-stage functionalization in today’s drug discovery
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume 14, Issue 11, Pages 1137-1149
Publisher
Informa UK Limited
Online
2019-08-14
DOI
10.1080/17460441.2019.1653850
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The importance of synthetic chemistry in the pharmaceutical industry
- (2019) Kevin R. Campos et al. SCIENCE
- Pharmaceutical diversification via palladium oxidative addition complexes
- (2019) Mycah R. Uehling et al. SCIENCE
- Late-Stage Functionalization of Drug-Like Molecules Using Diversinates
- (2018) Christian A. Kuttruff et al. ChemMedChem
- Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids
- (2018) Jacob A. Kautzky et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Generating carbyne equivalents with photoredox catalysis
- (2018) Zhaofeng Wang et al. NATURE
- Manganese-catalysed benzylic C(sp3)–H amination for late-stage functionalization
- (2018) Joseph R. Clark et al. Nature Chemistry
- Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals
- (2018) Marco Simonetti et al. Nature Chemistry
- Organic synthesis provides opportunities to transform drug discovery
- (2018) David C. Blakemore et al. Nature Chemistry
- Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives
- (2018) Michael Meanwell et al. Chemical Science
- Drug metabolism in drug discovery and development
- (2018) Zhoupeng Zhang et al. Acta Pharmaceutica Sinica B
- Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis
- (2018) Yufan Liang et al. NATURE
- Palladium-catalysed electrophilic aromatic C–H fluorination
- (2018) Kumiko Yamamoto et al. NATURE
- Expanding the medicinal chemistry synthetic toolbox
- (2018) Jonas Boström et al. NATURE REVIEWS DRUG DISCOVERY
- Exploration of new reaction tools for late-stage functionalization of complex chemicals
- (2018) Alejandra Dominguez-Huerta et al. CANADIAN JOURNAL OF CHEMISTRY
- Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group
- (2018) Jichen Zhao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Alkyl Sulfinates: Radical Precursors Enabling Drug Discovery
- (2018) Joel M. Smith et al. JOURNAL OF MEDICINAL CHEMISTRY
- Late-Stage Aromatic C–H Oxygenation
- (2018) Jonas Börgel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Chemoselective methylene oxidation in aromatic molecules
- (2018) Jinpeng Zhao et al. Nature Chemistry
- Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view
- (2017) Navriti Chadha et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Enabling Efficient Late-Stage Functionalization of Drug-Like Molecules with LC-MS and Reaction-Driven Data Processing
- (2017) Huifang Yao et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Remote, Late-Stage Oxidation of Aliphatic C–H Bonds in Amide-Containing Molecules
- (2017) Takeshi Nanjo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-selective and stereoselective functionalization of non-activated tertiary C–H bonds
- (2017) Kuangbiao Liao et al. NATURE
- Ligand-accelerated non-directed C–H functionalization of arenes
- (2017) Peng Wang et al. NATURE
- Selective sp3 C–H alkylation via polarity-match-based cross-coupling
- (2017) Chip Le et al. NATURE
- Direct α-C–H bond functionalization of unprotected cyclic amines
- (2017) Weijie Chen et al. Nature Chemistry
- Metal-free C–H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation
- (2017) Jennifer K. Matsui et al. Chemical Science
- Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
- (2016) Julien Genovino et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Modern Transition-Metal-Catalyzed Carbon–Halogen Bond Formation
- (2016) David A. Petrone et al. CHEMICAL REVIEWS
- The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
- (2016) Tim Cernak et al. CHEMICAL SOCIETY REVIEWS
- Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases
- (2016) Chelsea A. Huff et al. JOURNAL OF ORGANIC CHEMISTRY
- Photoredox Catalysis in Organic Chemistry
- (2016) Megan H. Shaw et al. JOURNAL OF ORGANIC CHEMISTRY
- C–H Xanthylation: A Synthetic Platform for Alkane Functionalization
- (2016) William L. Czaplyski et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Site-selective and stereoselective functionalization of unactivated C–H bonds
- (2016) Kuangbiao Liao et al. NATURE
- C–H functionalization of amines with aryl halides by nickel-photoredox catalysis
- (2016) Derek T. Ahneman et al. Chemical Science
- Iridium-Catalyzed Silylation of Aryl C–H Bonds
- (2015) Chen Cheng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Manganese-Catalyzed Late-Stage Aliphatic C–H Azidation
- (2015) Xiongyi Huang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evolution of C–H Bond Functionalization from Methane to Methodology
- (2015) John F. Hartwig JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Alcohols as alkylating agents in heteroarene C–H functionalization
- (2015) Jian Jin et al. NATURE
- Site-selective arene C-H amination via photoredox catalysis
- (2015) N. A. Romero et al. SCIENCE
- Site-Selective Aliphatic C–H Bromination Using N-Bromoamides and Visible Light
- (2014) Valerie A. Schmidt et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Catalyst-Controlled Aliphatic C–H Oxidations with a Predictive Model for Site-Selectivity
- (2013) Paul E. Gormisky et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize
- (2012) Carin C. C. Johansson Seechurn et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin
- (2012) W. Liu et al. SCIENCE
- Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions
- (2011) Keary M. Engle et al. ACCOUNTS OF CHEMICAL RESEARCH
- If CH Bonds Could Talk: Selective CH Bond Oxidation
- (2011) Timothy Newhouse et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
- (2011) Charles S. Yeung et al. CHEMICAL REVIEWS
- Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design
- (2010) Marcelo Hernandes et al. CURRENT DRUG TARGETS
- A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives
- (2010) Nicholas A. McGrath et al. JOURNAL OF CHEMICAL EDUCATION
- Manganese Porphyrins Catalyze Selective C−H Bond Halogenations
- (2010) Wei Liu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- How to improve R&D productivity: the pharmaceutical industry's grand challenge
- (2010) Steven M. Paul et al. NATURE REVIEWS DRUG DISCOVERY
- Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation
- (2010) M. S. Chen et al. SCIENCE
- Strain Release in CH Bond Activation?
- (2009) Ke Chen et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Spending on new drug development
- (2009) Christopher Paul Adams et al. HEALTH ECONOMICS
- Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
- (2009) Frank Lovering et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Many Roles for Fluorine in Medicinal Chemistry
- (2008) William K. Hagmann JOURNAL OF MEDICINAL CHEMISTRY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started