Exploration of new reaction tools for late-stage functionalization of complex chemicals

Synthesis of Difluoromethylthioesters from Aldehydes

(2018) Shi-Huan Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Formal Cross-Coupling of Diaryl Ethers with Amines: Slicing the 4-O -5 Linkage in Lignin Models

(2018) Huiying Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical difluoromethylthiolation of aromatics enabled by visible light

(2018) Jianbin Li et al.   Chemical Science

Radical fluoroalkylthiolation of aldehydes with PhSO2SRf (Rf = CF3, C2F5, CF2H or CH2F): a general protocol for the preparation of fluoroalkylthioesters

(2018) Bin Xu et al.   Organic Chemistry Frontiers

Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO2SCF2H or PhSO2SCF3

(2018) Bin Xu et al.   Organic Chemistry Frontiers

Lignocellulosic Biomass Transformations via Greener Oxidative Pretreatment Processes: Access to Energy and Value-Added Chemicals

(2018) Walter Den et al.   Frontiers in Chemistry

Synthesis of Monofluoromethylthioesters from Aldehydes

(2018) Shi-Huan Guo et al.   ADVANCED SYNTHESIS & CATALYSIS

Biomass-derived solvents as effective media for cross-coupling reactions and C–H functionalization processes

(2017) Stefano Santoro et al.   GREEN CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalyst-Free and Redox-Neutral Innate Trifluoromethylation and Alkylation of Aromatics Enabled by Light

(2017) Peng Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Difluoromethylthiolation of Phenols and Related Compounds with a HF2CSO2Na/Ph2PCl/Me3SiCl System

(2017) Zhongyan Huang et al.   ORGANIC LETTERS

One-Pot Synthesis of Difluoromethyl Thioethers from Thiourea and Diethyl Bromodifluoromethylphosphonate

(2017) Tianqi Ding et al.   ORGANIC LETTERS

[[(Ethoxycarbonyl)difluoromethyl]thio]phthalimide: A Shelf-Stable, Electrophilic Reagent with a Convertible Group for the Synthesis of Diversified Fluoroalkylthiolated Compounds

(2017) Feng Shen et al.   ORGANIC LETTERS

A Two-Step, One-Pot, and Multigram-Scale Synthesis of N-Difluoromethylthiophthalimide

(2017) Dianhu Zhu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Formal aromaticity transfer for palladium-catalyzed coupling between phenols and pyrrolidines/indolines

(2017) Zihang Qiu et al.   Chemical Science

Transition-metal free direct difluoromethylthiolation of electron-rich aromatics with difluoromethanesulfonyl chloride

(2017) Xia Zhao et al.   Organic Chemistry Frontiers

Direct N-alkylation of unprotected amino acids with alcohols

(2017) Tao Yan et al.   Science Advances

Phosphorylation of Glycine Derivatives via Copper(I)-Catalyzed Csp 3 −H Bond Functionalization

(2016) Huizhen Zhi et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

(2016) Ermal Ismalaj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Electrophilic Reagent for the Direct Introduction of the SCF2 PO(OEt)2 Group to Molecules

(2016) Heng-Ying Xiong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PhSO2SCF2H: A Shelf-Stable, Easily Scalable Reagent for Radical Difluoromethylthiolation

(2016) Dianhu Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances in the Synthesis of SCF2H- and SCF2FG-Containing Molecules

(2016) Heng-Ying Xiong et al.   CHEMISTRY-A EUROPEAN JOURNAL

En Route to a Practical Primary Alcohol Deoxygenation

(2016) Xi-Jie Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple and Clean Photoinduced Aromatic Trifluoromethylation Reaction

(2016) Lu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Method for the N-Arylation of Amino Acid Esters with Aryl Triflates

(2016) Sandra M. King et al.   ORGANIC LETTERS

Functionalization of C(sp3)-H bonds using a transient directing group

(2016) F.-L. Zhang et al.   SCIENCE

Palladium-catalyzed difluoromethylthiolation of heteroaryl bromides, iodides, triflates and aryl iodides

(2016) Jiang Wu et al.   Chemical Science

An Adventure in Sustainable Cross-Coupling of Phenols and Derivatives via Carbon–Oxygen Bond Cleavage

(2016) Huiying Zeng et al.   ACS Catalysis

Difluoromethanesulfonyl hypervalent iodonium ylides for electrophilic difluoromethylthiolation reactions under copper catalysis

(2016) Sadayuki Arimori et al.   Royal Society Open Science

Exploration of Earth-Abundant Transition Metals (Fe, Co, and Ni) as Catalysts in Unreactive Chemical Bond Activations

(2015) Bo Su et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cross-Couplings Using Aryl Ethers via C–O Bond Activation Enabled by Nickel Catalysts

(2015) Mamoru Tobisu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper-Promoted Sandmeyer Difluoromethylthiolation of Aryl and Heteroaryl Diazonium Salts

(2015) Jiang Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Difluoromethyl Thioethers from Difluoromethyl Trimethylsilane and Organothiocyanates Generated In Situ

(2015) Bilguun Bayarmagnai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Formal Direct Cross-Coupling of Phenols with Amines

(2015) Zhengwang Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Transformation of Lignin for the Production of Chemicals and Fuels

(2015) Changzhi Li et al.   CHEMICAL REVIEWS

Strategies for the Conversion of Lignin to High-Value Polymeric Materials: Review and Perspective

(2015) Brianna M. Upton et al.   CHEMICAL REVIEWS

Synthesis of Aryl Tri- and Difluoromethyl Thioethers via a CH-Thiocyanation/Fluoroalkylation Cascade

(2015) Kévin Jouvin et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic, difluorocarbene-based S-difluoromethylation of thiocarbonyl compounds

(2015) Kohei Fuchibe et al.   JOURNAL OF FLUORINE CHEMISTRY

N-Difluoromethylthiophthalimide: A Shelf-Stable, Electrophilic Reagent for Difluoromethylthiolation

(2015) Dianhu Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Room temperature N-arylation of amino acids and peptides using copper(i) and β-diketone

(2015) Krishna K. Sharma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers

(2015) Furkan H. Isikgor et al.   Polymer Chemistry

Gold-catalyzed tandem reactions of amide–aldehyde–alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles

(2015) Pierre Querard et al.   Chemical Science

Palladium-catalyzed reductive coupling of phenols with anilines and amines: efficient conversion of phenolic lignin model monomers and analogues to cyclohexylamines

(2015) Zhengwang Chen et al.   Chemical Science

Catalytic dehydrogenative aromatization: an alternative route to functionalized arenes

(2015) Simon A. Girard et al.   Organic Chemistry Frontiers

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Synthetic Methods for Compounds Having CF3–S Units on Carbon by Trifluoromethylation, Trifluoromethylthiolation, Triflylation, and Related Reactions

(2014) Xiu-Hua Xu et al.   CHEMICAL REVIEWS

Metal-catalyzed activation of ethers via C–O bond cleavage: a new strategy for molecular diversity

(2014) Josep Cornella et al.   CHEMICAL SOCIETY REVIEWS

Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory

(2014) K. C. Nicolaou   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

The Barbier–Grignard-type arylation of aldehydes using unactivated aryl iodides in water

(2014) Feng Zhou et al.   Nature Communications

Peptidomimetics as a new generation of antimicrobial agents: current progress

(2014) Patricia Mendez-Samperio   Infection and Drug Resistance

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Difluoromethyl Ethers with Difluoromethyltriflate

(2013) Patrick S. Fier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A3-Coupling catalyzed by robust Au nanoparticles covalently bonded to HS-functionalized cellulose nanocrystalline films

(2013) Jian-Lin Huang et al.   Beilstein Journal of Organic Chemistry

Iridium-Catalyzed Direct Dehydroxylation of Alcohols

(2013) Jian-Lin Huang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Use of Fluoroform as a Source of Difluorocarbene in the Synthesis of Difluoromethoxy- and Difluorothiomethoxyarenes

(2013) Charles S. Thomoson et al.   JOURNAL OF ORGANIC CHEMISTRY

Research and development of a novel rice herbicide, pyrimisulfan#

(2013) Takumi Yoshimura et al.   JOURNAL OF PESTICIDE SCIENCE

Pd-Catalyzed Semmler–Wolff Reactions for the Conversion of Substituted Cyclohexenone Oximes to Primary Anilines

(2013) Wan Pyo Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

S-, N-, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate

(2013) Vaibhav P. Mehta et al.   ORGANIC LETTERS

Straightforward Solvent-Free Heterogeneous Palladium-Catalyzed Synthesis of Arylamines from Nonaromatic Substrates by Dehydrogenative Alkylation

(2013) Marc Sutter et al.   ACS Sustainable Chemistry & Engineering

Catalytic Aerobic Synthesis of Aromatic Ethers from Non-Aromatic Precursors

(2012) Marc-Olivier Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Aerobic Dehydrogenative Aromatization of Cyclohexanone Imines to Arylamines

(2012) Alakananda Hajra et al.   ORGANIC LETTERS

Pd-Catalyzed Synthesis of Aryl Amines via Oxidative Aromatization of Cyclic Ketones and Amines with Molecular Oxygen

(2012) Simon A. Girard et al.   ORGANIC LETTERS

Palladium-Catalyzed One-Pot Diarylamine Formation from Nitroarenes and Cyclohexanones

(2012) Yanjun Xie et al.   ORGANIC LETTERS

Site-Specific Modification of Amino Acids and Peptides by Aldehyde–Alkyne–Amine Coupling under Ambient Aqueous Conditions

(2012) Nick Uhlig et al.   ORGANIC LETTERS

Difluoromethylation of O-, S-, N-, C-Nucleophiles Using Difluoromethyltri(n-butyl)ammonium Chloride as a New Difluorocarbene Source

(2011) Fei Wang et al.   CHINESE JOURNAL OF CHEMISTRY

N,N-Dimethyl-S-difluoromethyl-S-phenylsulfoximinium tetrafluoroborate: A versatile electrophilic difluoromethylating reagent

(2011) G.K. Surya Prakash et al.   JOURNAL OF FLUORINE CHEMISTRY

Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry

(2011) Artur Mucha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gold-mediated bifunctional modification of oligosaccharidesvia a three-component coupling reaction

(2011) Karen Ka-Yan Kung et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzed Aerobic Dehydrogenation of Substituted Cyclohexanones to Phenols

(2011) Y. Izawa et al.   SCIENCE

Exploration of New C−O Electrophiles in Cross-Coupling Reactions

(2010) Da-Gang Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Development of Catalytic Nucleophilic Additions of Terminal Alkynes in Water†

(2010) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

Copper(II) Triflate-Catalyzed Three-Component Coupling of Aldehydes, Alkynes and Carbamates

(2010) Xiao-Yong Dou et al.   ADVANCED SYNTHESIS & CATALYSIS

General and Efficient Copper-Catalyzed Three-Component Coupling Reaction towards Imidazoheterocycles: One-Pot Synthesis of Alpidem and Zolpidem

(2010) Natalia Chernyak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

(2010) Chu-Pei Xu et al.   CHEMICAL COMMUNICATIONS

Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds

(2010) Brad M. Rosen et al.   CHEMICAL REVIEWS

Fe3O4 nanoparticles: a robust and magnetically recoverable catalyst for three-component coupling of aldehyde, alkyne and amine

(2010) Tieqiang Zeng et al.   GREEN CHEMISTRY

Silver-Catalyzed Oxidative Coupling of Terminal Aromatic Alkynes and Benzylic Ethers

(2010) Chao-Jun Li et al.   HETEROCYCLES

Gold-Catalyzed Three-Component Tandem Process: An Efficient and Facile Assembly of Complex Butenolides from Alkynes, Amines, and Glyoxylic Acid

(2010) Qiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe3O4Nanoparticle-Supported Copper(I) Pybox Catalyst: Magnetically Recoverable Catalyst for Enantioselective Direct-Addition of Terminal Alkynes to Imines

(2010) Tieqiang Zeng et al.   ORGANIC LETTERS

The Copper-Catalyzed Decarboxylative Coupling of the sp3-Hybridized Carbon Atoms of α-Amino Acids

(2009) Hai-Peng Bi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-catalyzed aerobic phosphonation of sp3 C–H bonds

(2009) Olivier Baslé et al.   CHEMICAL COMMUNICATIONS

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS

Propargyl Amine Synthesis Catalysed by Gold and Copper Thin Films by Using Microwave-Assisted Continuous-Flow Organic Synthesis (MACOS)

(2009) Gjergji Shore et al.   CHEMISTRY-A EUROPEAN JOURNAL

New trends in the chemistry of α-fluorinated ethers, thioethers, amines and phosphines

(2009) Baptiste Manteau et al.   JOURNAL OF FLUORINE CHEMISTRY

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS

Site-specific C-functionalization of free-(NH) peptides and glycine derivatives via direct C-H bond functionalization

(2009) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Propargylamines by a Copper-Catalyzed Tandem Anti-Markovnikov Hydroamination and Alkyne Addition

(2009) Huan-Feng Jiang et al.   SYNLETT

Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor

(2009) Yossi Zafrani et al.   TETRAHEDRON

Iron-catalyzed three-component coupling of aldehyde, alkyne, and amine under neat conditions in air

(2009) Wen-Wen Chen et al.   TETRAHEDRON LETTERS

Enantioselective, copper(I)-catalyzed three-component reaction for the synthesis of β,γ-alkynyl α-amino acid derivatives

(2009) Zhihui Shao et al.   TETRAHEDRON-ASYMMETRY

Copper‐Catalyzed Four‐Component Coupling between Aldehydes, Amines, Alkynes, and Carbon Dioxide

(2008) Woo‐Jin Yoo et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Carbonyl Addition through Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents

(2008) John F. Bower et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functionalizing Glycine Derivatives by Direct CC Bond Formation

(2008) Liang Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium xantphos complexes in hydrogen transfer processes: reactivity and mechanistic studies

(2008) Araminta E. W. Ledger et al.   DALTON TRANSACTIONS

Electrophilic (phenylsulfonyl)difluoromethylation of thiols with a hypervalent iodine(III)–CF2SO2Ph reagent

(2008) Wei Zhang et al.   TETRAHEDRON LETTERS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH