TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity

RIG-I and Other RNA Sensors in Antiviral Immunity

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Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

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Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

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Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

(2017) Nan Qi et al.   Nature Communications

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

(2017) Yuheng Shi et al.   Nature Communications

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

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PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

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TRAF3IP3, a novel autophagy up-regulated gene, is involved in marginal zone B lymphocyte development and survival

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T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response

(2015) Yuheng Shi et al.   Nature Communications

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

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Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

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Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

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Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex

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The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

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The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

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Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network

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Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

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Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

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Innate and adaptive immune responses to viral infection and vaccination

(2011) Taiki Aoshi et al.   Current Opinion in Virology

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

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Pattern Recognition Receptors and Inflammation

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Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

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Recognition of viral nucleic acids in innate immunity

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TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

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Pattern recognition receptors and control of adaptive immunity

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NLRX1 is a regulator of mitochondrial antiviral immunity

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