Making and breaking symmetry in development, growth and disease

Developmental Biology: Go with the Flow to Keep the Body Straight

(2019) Daniel T. Grimes   CURRENT BIOLOGY

The development of CRISPR for a mollusc establishes the formin Lsdia1 as the long-sought gene for snail dextral/sinistral coiling

(2019) Masanori Abe et al.   DEVELOPMENT

Genes and mechanisms of heterotaxy: patients drive the search

(2019) Emily Sempou et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A Conserved Role of the Unconventional Myosin 1d in Laterality Determination

(2018) Melanie Tingler et al.   CURRENT BIOLOGY

Left–Right Asymmetry: Myosin 1D at the Center

(2018) Shiaulou Yuan et al.   CURRENT BIOLOGY

Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry

(2018) Thomas Juan et al.   Nature Communications

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice

(2018) Alberto Roselló-Díez et al.   PLOS BIOLOGY

Developmental Biology: Reissner’s Fiber and Straightening of the Body Axis

(2018) Wolfgang Driever   CURRENT BIOLOGY

The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis

(2018) Yasmine Cantaut-Belarif et al.   CURRENT BIOLOGY

Cross-limb communication duringXenopushind-limb regenerative response: non-local bioelectric injury signals

(2018) Sera M. Busse et al.   DEVELOPMENT

Vertebrate myosin 1d regulates left–right organizer morphogenesis and laterality

(2018) Manush Saydmohammed et al.   Nature Communications

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

(2018) Jenna R. Sternberg et al.   Nature Communications

Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position

(2018) Chloe Moreau et al.   CURRENT BIOLOGY

Left-right asymmetry in heart development and disease: forming the right loop

(2018) Audrey Desgrange et al.   DEVELOPMENT

Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis

(2018) Xiaoli Zhang et al.   NATURE GENETICS

Intrinsic cellular chirality regulates left–right symmetry breaking during cardiac looping

(2018) Poulomi Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Cell Chirality Revealed by Three-Dimensional Spontaneous Rotation

(2018) Amanda S. Chin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular to organismal chirality is induced by the conserved myosin 1D

(2018) G. Lebreton et al.   SCIENCE

A right-handed signalling pathway drives heart looping in vertebrates

(2017) Oscar H. Ocaña et al.   NATURE

The development and functions of multiciliated epithelia

(2017) Nathalie Spassky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cerberus–Nodal–Lefty–Pitx signaling cascade controls left–right asymmetry in amphioxus

(2017) Guang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Left–Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis

(2017) Daniel T. Grimes et al.   TRENDS IN GENETICS

Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought

(2017) Curtis W. Boswell et al.   TRENDS IN GENETICS

The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry

(2017) Gonçalo C. Vilhais-Neto et al.   Nature Communications

SHH Protein Variance in the Limb Bud Is Constrained by Feedback Regulation and Correlates with Altered Digit Patterning

(2017) Rui Zhang et al.   G3-Genes Genomes Genetics

Cranial asymmetry arises later in the life history of the blind Mexican cavefish, Astyanax mexicanus

(2017) Amanda K. Powers et al.   PLoS One

Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog

(2016) Angus Davison et al.   CURRENT BIOLOGY

Motile and non-motile cilia in human pathology: from function to phenotypes

(2016) Hannah M Mitchison et al.   JOURNAL OF PATHOLOGY

Cell chirality: emergence of asymmetry from cell culture

(2016) Leo Q. Wan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature

(2016) D. T. Grimes et al.   SCIENCE

Diaphanous gene mutation affects spiral cleavage and chirality in snails

(2016) Reiko Kuroda et al.   Scientific Reports

c21orf59/kurly Controls Both Cilia Motility and Polarization

(2016) Kimberly M. Jaffe et al.   Cell Reports

Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation

(2016) Fatima A. Sulaiman et al.   PLoS Genetics

How the embryo makes a limb: determination, polarity and identity

(2015) Cheryll Tickle   JOURNAL OF ANATOMY

Cellular chirality arising from the self-organization of the actin cytoskeleton

(2015) Yee Han Tee et al.   NATURE CELL BIOLOGY

Adolescent idiopathic scoliosis

(2015) Jack C. Cheng et al.   Nature Reviews Disease Primers

CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation

(2014) Rim Hjeij et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Retinoic acid controls body axis extension by directly repressing Fgf8 transcription

(2014) S. Kumar et al.   DEVELOPMENT

The evolution and conservation of left-right patterning mechanisms

(2014) M. Blum et al.   DEVELOPMENT

Symmetry breakage in the vertebrate embryo: When does it happen and how does it work?

(2014) Martin Blum et al.   DEVELOPMENTAL BIOLOGY

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Formation and Segmentation of the Vertebrate Body Axis

(2013) Bertrand Bénazéraf et al.   Annual Review of Cell and Developmental Biology

Regulated tissue fluidity steers zebrafish body elongation

(2013) A. K. Lawton et al.   DEVELOPMENT

A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality

(2013) Laura N. Vandenberg et al.   DEVELOPMENTAL BIOLOGY

Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry

(2013) Justus Veerkamp et al.   DEVELOPMENTAL CELL

Integration of Left-Right Pitx2 Transcription and Wnt Signaling Drives Asymmetric Gut Morphogenesis via Daam2

(2013) Ian C. Welsh et al.   DEVELOPMENTAL CELL

Asymmetric flies

(2013) Vincent Debat et al.   FLY

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

(2013) Marko T. Boskovski et al.   NATURE

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

(2013) Emily S. Noël et al.   Nature Communications

Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry

(2013) Kari F. Lenhart et al.   PLoS Genetics

A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis

(2012) Duncan B. Sparrow et al.   CELL

Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development

(2012) T. Matsui et al.   DEVELOPMENT

BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia

(2012) Eva E. Fischerauer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

Fluid flow and interlinked feedback loops establish left–right asymmetric decay of Cerl2 mRNA

(2012) Tetsuya Nakamura et al.   Nature Communications

ATP4a Is Required for Wnt-Dependent Foxj1 Expression and Leftward Flow in Xenopus Left-Right Development

(2012) Peter Walentek et al.   Cell Reports

Connexin26-mediated transfer of laterality cues in Xenopus

(2012) T. Beyer et al.   Biology Open

Histone deacetylase activity is necessary for left-right patterning during vertebrate development

(2011) Katia Carneiro et al.   BMC DEVELOPMENTAL BIOLOGY

Pattern, Growth, and Control

(2011) Arthur D. Lander   CELL

Serotonin Signaling Is Required for Wnt-Dependent GRP Specification and Leftward Flow in Xenopus

(2011) Tina Beyer et al.   CURRENT BIOLOGY

Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish

(2011) K. F. Lenhart et al.   DEVELOPMENT

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2

(2011) S. Field et al.   DEVELOPMENT

On the growth and form of the gut

(2011) Thierry Savin et al.   NATURE

Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis

(2011) Kiichiro Taniguchi et al.   SCIENCE

The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus

(2010) Axel Schweickert et al.   CURRENT BIOLOGY

Rere controls retinoic acid signalling and somite bilateral symmetry

(2010) Gonçalo C. Vilhais-Neto et al.   NATURE

Left-Right Function of dmrt2 Genes Is Not Conserved between Zebrafish and Mouse

(2010) Raquel Lourenço et al.   PLoS One

Arms and the Man: The Problem of Symmetric Growth

(2010) Lewis Wolpert   PLOS BIOLOGY

Disorders of left-right asymmetry: Heterotaxy and situs inversus

(2009) Mardi J. Sutherland et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Cell Movements at Hensen's Node Establish Left/Right Asymmetric Gene Expression in the Chick

(2009) J. Gros et al.   SCIENCE

Asymmetric Lower-Limb Malformations in Individuals with Homeobox PITX1 Gene Mutation

(2008) Christina A. Gurnett et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Chirality of Gut Rotation Derives from Left-Right Asymmetric Changes in the Architecture of the Dorsal Mesentery

(2008) Nicole M. Davis et al.   DEVELOPMENTAL CELL

Autonomic Regulation of Liver Regeneration After Partial Hepatectomy in Mice

(2008) Osamu Ikeda et al.   JOURNAL OF SURGICAL RESEARCH

Nodal signalling is involved in left–right asymmetry in snails

(2008) Cristina Grande et al.   NATURE

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

(2008) Maksim V. Plikus et al.   NATURE

Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart

(2008) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion

(2008) N. A. Kurpios et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing segmentation and laterality during vertebrate development

(2008) Tim Brend et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY