Left-right asymmetry in heart development and disease: forming the right loop

The heart tube forms and elongates through dynamic cell rearrangement coordinated with foregut extension

(2018) Hinako Kidokoro et al.   DEVELOPMENT

No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird

(2018) Rebecca E. Koch et al.   Nature Communications

Myosin1D is an evolutionarily conserved regulator of animal left–right asymmetry

(2018) Thomas Juan et al.   Nature Communications

Chiral cell sliding drives left-right asymmetric organ twisting

(2018) Mikiko Inaki et al.   eLife

Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

(2018) Hajime Fukui et al.   eLife

Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

(2018) Almary Guerra et al.   eLife

A right-handed signalling pathway drives heart looping in vertebrates

(2017) Oscar H. Ocaña et al.   NATURE

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

(2017) Sheng Chih Jin et al.   NATURE GENETICS

Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

(2017) Kenzo Ivanovitch et al.   eLife

A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

(2017) Jean-François Le Garrec et al.   eLife

Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

(2016) Yongchang Ji et al.   DEVELOPMENTAL BIOLOGY

Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment

(2016) Ding Li et al.   DEVELOPMENTAL BIOLOGY

Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways

(2016) Erin M. Hagen et al.   HUMAN GENETICS

Congenital Heart Disease and Primary Ciliary Dyskinesia

(2016) Mike John Harrison et al.   Paediatric Respiratory Reviews

Chirality of the cytoskeleton in the origins of cellular asymmetry

(2016) Peter Satir   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prickle1mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects

(2016) Brian C. Gibbs et al.   Biology Open

The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila

(2015) Nicanor González-Morales et al.   DEVELOPMENTAL CELL

Cardiac and Non-Cardiac Abnormalities in Heterotaxy Syndrome

(2015) Smita Mishra   INDIAN JOURNAL OF PEDIATRICS

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

(2015) You Li et al.   NATURE

MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates

(2015) Anne Guimier et al.   NATURE GENETICS

Laterality defects in the national birth defects prevention study (1998-2007): Birth prevalence and descriptive epidemiology

(2014) Angela E. Lin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment

(2014) Boon-Seng Soh et al.   CELL RESEARCH

Tbx1 Coordinates Addition of Posterior Second Heart Field Progenitor Cells to the Arterial and Venous Poles of the Heart

(2014) M. Sameer Rana et al.   CIRCULATION RESEARCH

TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field

(2014) A. Francou et al.   DEVELOPMENT

Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality

(2014) Olga Simmons et al.   DEVELOPMENTAL DYNAMICS

Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa

(2014) J.-B. Coutelis et al.   EMBO REPORTS

Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome

(2014) Tanvi Sinha et al.   HUMAN MOLECULAR GENETICS

Primary ciliary dyskinesia: critical evaluation of clinical symptoms and diagnosis in patients with normal and abnormal ultrastructure

(2014) Mieke Boon et al.   Orphanet Journal of Rare Diseases

Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

(2014) Simon A. Ramsbottom et al.   PLoS Genetics

Rac1 Signaling Is Critical to Cardiomyocyte Polarity and Embryonic Heart Development

(2014) Carmen Leung et al.   Journal of the American Heart Association

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

(2014) Elena N. Dedkova et al.   Frontiers in Physiology

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis

(2013) Ashok Mittal et al.   DEVELOPMENTAL BIOLOGY

Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry

(2013) Justus Veerkamp et al.   DEVELOPMENTAL CELL

On the role of intrinsic and extrinsic forces in early cardiac S-looping

(2013) Ashok Ramasubramanian et al.   DEVELOPMENTAL DYNAMICS

The CBC social network

(2013) Andrea Du Toit   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Great Vessel and Coronary Artery Anatomy in Transposition and Other Coronary Anomalies

(2013) Sasi Sithamparanathan et al.   JACC-Cardiovascular Imaging

Highly confined ions store charge more efficiently in supercapacitors

(2013) C. Merlet et al.   Nature Communications

Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry

(2013) Kari F. Lenhart et al.   PLoS Genetics

Asymmetric Fate of the Posterior Part of the Second Heart Field Results in Unexpected Left/Right Contributions to Both Poles of the Heart

(2012) Jorge N. Domínguez et al.   CIRCULATION RESEARCH

Lineage Tree for the Venous Pole of the Heart

(2012) Fabienne Lescroart et al.   CIRCULATION RESEARCH

Wnt5a and Wnt11 are essential for second heart field progenitor development

(2012) E. D. Cohen et al.   DEVELOPMENT

Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart

(2012) J.-F. Le Garrec et al.   DEVELOPMENT

Left-right patterning: conserved and divergent mechanisms

(2012) T. Nakamura et al.   DEVELOPMENT

Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis

(2012) Tanvi Sinha et al.   DEVELOPMENTAL BIOLOGY

Growth of the developing mouse heart: An interactive qualitative and quantitative 3D atlas

(2012) Bouke A. de Boer et al.   DEVELOPMENTAL BIOLOGY

Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium

(2011) Grazia Ammirabile et al.   CARDIOVASCULAR RESEARCH

Zebrafish cardiac development requires a conserved secondary heart field

(2011) D. Hami et al.   DEVELOPMENT

Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish

(2011) Savo Lazic et al.   DEVELOPMENTAL BIOLOGY

Essential roles of fibronectin in the development of the left–right embryonic body plan

(2011) Maria V. Pulina et al.   DEVELOPMENTAL BIOLOGY

Latent TGF-β binding protein 3 identifies a second heart field in zebrafish

(2011) Yong Zhou et al.   NATURE

Congenitally corrected transposition

(2011) Gonzalo A Wallis et al.   Orphanet Journal of Rare Diseases

Chirality in Planar Cell Shape Contributes to Left-Right Asymmetric Epithelial Morphogenesis

(2011) Kiichiro Taniguchi et al.   SCIENCE

Generation of Diverse Biological Forms through Combinatorial Interactions between Tissue Polarity and Growth

(2011) Richard Kennaway et al.   PLoS Computational Biology

Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo

(2010) F. Lescroart et al.   DEVELOPMENT

The miR-143-adducin3 pathway is essential for cardiac chamber morphogenesis

(2010) D. C. Deacon et al.   DEVELOPMENT

Characterization of Pitx2c expression in the mouse heart using a reporter transgene

(2010) Milena B. Furtado et al.   DEVELOPMENTAL DYNAMICS

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

(2009) E. de Pater et al.   DEVELOPMENT

Familial transposition of the great arteries caused by multiple mutations in laterality genes

(2009) A. De Luca et al.   HEART

Left cardiac isomerism in the Sonic hedgehog null mouse

(2009) Victoria Hildreth et al.   JOURNAL OF ANATOMY

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis

(2009) Courtney M Karner et al.   NATURE GENETICS

Asymmetric Involution of the Myocardial Field Drives Heart Tube Formation in Zebrafish

(2008) Stefan Rohr et al.   CIRCULATION RESEARCH

BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment

(2008) N. Mine et al.   DEVELOPMENT

Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed

(2008) D. Galli et al.   DEVELOPMENT

Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells

(2008) Kelly A. Smith et al.   DEVELOPMENTAL CELL

The Chirality of Gut Rotation Derives from Left-Right Asymmetric Changes in the Architecture of the Dorsal Mesentery

(2008) Nicole M. Davis et al.   DEVELOPMENTAL CELL

Time-lapse analysis reveals local asymmetrical changes in C-looping heart tube

(2008) Hinako Kidokoro et al.   DEVELOPMENTAL DYNAMICS

Nodal signaling promotes the speed and directional movement of cardiomyocytes in zebrafish

(2008) Maria Ines Medeiros de Campos-Baptista et al.   DEVELOPMENTAL DYNAMICS

Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping

(2008) Wenge Lu et al.   DEVELOPMENTAL DYNAMICS

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4

(2008) M. B. Furtado et al.   GENES & DEVELOPMENT

Transposition of the great arteries

(2008) Paula Martins et al.   Orphanet Journal of Rare Diseases

Direct and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heart

(2008) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic acid deficiency alters second heart field formation

(2008) L. Ryckebusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA