JAK1/2 pathway inhibition suppresses M2 polarization and overcomes resistance of myeloma to lenalidomide by reducing TRIB1, MUC1, CD44, CXCL12, and CXCR4 expression

The anti-myeloma effects of the selective JAK1 inhibitor (INCB052793) alone and in combination in vitro and in vivo

(2019) Eric Sanchez et al.   ANNALS OF HEMATOLOGY

Targeting signaling pathways in multiple myeloma: Pathogenesis and implication for treatments

(2018) Jingping Hu et al.   CANCER LETTERS

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects

(2018) Farhad Dehkhoda et al.   Frontiers in Endocrinology

A phase 1 trial of ruxolitinib, lenalidomide, and methylprednisolone for relapsed/refractory multiple myeloma patients.

(2018) James R. Berenson et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

(2018) Shicheng Su et al.   CELL

Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects

(2017) Haiming Chen et al.   MOLECULAR CANCER RESEARCH

MUC1-C drives MYC in multiple myeloma

(2016) Ashujit Tagde et al.   BLOOD

Alternatively activated macrophages determine repair of the infarcted adult murine heart

(2016) Manabu Shiraishi et al.   JOURNAL OF CLINICAL INVESTIGATION

MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis

(2016) Takashi Yokoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIB1 Is Regulated Post-Transcriptionally by Proteasomal and Non-Proteasomal Pathways

(2016) Sébastien Soubeyrand et al.   PLoS One

The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC

(2016) Lei Li et al.   Oncology Letters

The role of Trib1 in myeloid leukaemogenesis and differentiation

(2015) T. Nakamura   BIOCHEMICAL SOCIETY TRANSACTIONS

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

(2015) Igor Malyshev et al.   Biomed Research International

Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma

(2015) J. L. Jensen et al.   Cancer Immunology Research

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype

(2015) Katia Beider et al.   Oncotarget

Multiple regulation pathways and pivotal biological functions of STAT3 in cancer

(2015) Jie Yuan et al.   Scientific Reports

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL

(2014) I. Appelmann et al.   BLOOD

Targeting the bone marrow microenvironment in multiple myeloma

(2014) Yawara Kawano et al.   IMMUNOLOGICAL REVIEWS

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

(2014) Ailian Xiong et al.   Cancers

The metastasis-promoting roles of tumor-associated immune cells

(2013) Heath A. Smith et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Macrophages in multiple myeloma: emerging concepts and therapeutic implications

(2013) Fotis Asimakopoulos et al.   LEUKEMIA & LYMPHOMA

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages

(2013) Takashi Satoh et al.   NATURE

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells

(2012) Jaehyup Kim et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting of Adhesion Molecules as a Therapeutic Strategy in Multiple Myeloma

(2012) Paola Neri et al.   CURRENT CANCER DRUG TARGETS

Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation

(2011) Takashi Yokoyama et al.   CANCER SCIENCE

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation

(2008) Kepeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone marrow microenvironment and the identification of new targets for myeloma therapy

(2008) K Podar et al.   LEUKEMIA