Characteristics of splenic CD8+T cell exhaustion in patients with hepatitis C

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

(2013) Erin E. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased frequency of CD73+ CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion

(2013) Ilona Tóth et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

(2013) Li-Rung Huang et al.   NATURE IMMUNOLOGY

Re-Evaluation of PD-1 Expression by T Cells as a Marker for Immune Exhaustion during SIV Infection

(2013) Jung Joo Hong et al.   PLoS One

Factors That Determine the Antiviral Efficacy of HCV-Specific CD8+ T Cells Ex Vivo

(2012) Bianca Seigel et al.   GASTROENTEROLOGY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

(2012) Taheri Sathaliyawala et al.   IMMUNITY

Two discreet subsets of CD8 T cells modulate PLP91–110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

(2012) Ashutosh K. Mangalam et al.   JOURNAL OF AUTOIMMUNITY

Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice

(2012) Lei Tian et al.   JOURNAL OF AUTOIMMUNITY

T cells, murine chronic graft-versus-host disease and autoimmunity

(2012) Robert A. Eisenberg et al.   JOURNAL OF AUTOIMMUNITY

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Improvement of Psoriasis after Tonsillectomy Is Associated with a Decrease in the Frequency of Circulating T Cells That Recognize Streptococcal Determinants and Homologous Skin Determinants

(2012) R. H. Thorleifsdottir et al.   JOURNAL OF IMMUNOLOGY

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis

(2011) N. Hashimoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers

(2011) Wendy W. Unger et al.   JOURNAL OF AUTOIMMUNITY

Laparoscopic splenectomy with interferon therapy in 100 hepatitis-C-virus-cirrhotic patients with hypersplenism and thrombocytopenia

(2011) Tomohiko Akahoshi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Post-splenectomy and hyposplenic states

(2011) Antonio Di Sabatino et al.   LANCET

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Chronic Hepatitis C Infection

(2011) Hugo R. Rosen   NEW ENGLAND JOURNAL OF MEDICINE

Splenectomy Associated Changes in IgM Memory B Cells in an Adult Spleen Registry Cohort

(2011) Paul U. Cameron et al.   PLoS One

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Galectin-9/TIM-3 Interaction Regulates Virus-Specific Primary and Memory CD8+ T Cell Response

(2010) Sharvan Sehrawat et al.   PLoS Pathogens

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism

(2009) Tomohiko Akahoshi et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Myeloid Dendritic Cells of Patients With Chronic HCV Infection Induce Proliferation of Regulatory T Lymphocytes

(2008) Angela Dolganiuc et al.   GASTROENTEROLOGY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY