Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia

Increased autocrine interleukin-6 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia

(2019) Hua-Qing Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia

(2018) Md Kamrul Hasan et al.   BLOOD

Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia

(2018) Michael Y. Choi et al.   Cell Stem Cell

Cirmtuzumab inhibits ibrutinib-resistant, Wnt5a-induced Rac1 activation and proliferation in mantle cell lymphoma

(2018) Jian Yu et al.   Oncotarget

Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells

(2018) Md Kamrul Hasan et al.   LEUKEMIA

Activation of the B-cell receptor successively activates NF-κB and STAT3 in chronic lymphocytic leukemia cells

(2017) Uri Rozovski et al.   INTERNATIONAL JOURNAL OF CANCER

Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells

(2017) J Yu et al.   LEUKEMIA

Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells

(2017) M K Hasan et al.   LEUKEMIA

Chronic lymphocytic leukaemia

(2017) Thomas J. Kipps et al.   Nature Reviews Disease Primers

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

(2016) B. Cui et al.   BLOOD

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib

(2016) J Yu et al.   LEUKEMIA

NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions

(2016) Larry Mansouri et al.   SEMINARS IN CANCER BIOLOGY

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia

(2016) Feng-Ting Liu et al.   Oncotarget

Biological functions of macrophage-derived Wnt5a, and its roles in human diseases

(2016) Yue Shao et al.   Oncotarget

Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A

(2015) Y. Li et al.   BLOOD

Interleukin-6 in CLL: accelerator or brake?

(2015) R. Lapalombella   BLOOD

Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

(2015) P. Janovska et al.   CLINICAL CANCER RESEARCH

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

(2015) Michael Y. Choi et al.   Clinical Lymphoma Myeloma & Leukemia

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

(2014) U. Rozovski et al.   BLOOD

MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia

(2014) B. Cui et al.   BLOOD

ROR1 can interact with TCL1 and enhance leukemogenesis in E -TCL1 transgenic mice

(2013) G. F. Widhopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Onco-Embryonic Antigen ROR1 Is Expressed by a Variety of Human Cancers

(2012) Suping Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia

(2012) Ju-Yoon Yoon et al.   LEUKEMIA & LYMPHOMA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia

(2011) X.-J. Yan et al.   BLOOD

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(2011) Carlo Calissano et al.   MOLECULAR MEDICINE

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

(2010) I. Hazan-Halevy et al.   BLOOD

CCL3 (MIP-1 ) plasma levels and the risk for disease progression in chronic lymphocytic leukemia

(2010) M. Sivina et al.   BLOOD

Stat3 Activates the Receptor Tyrosine Kinase Like Orphan Receptor-1 Gene in Chronic Lymphocytic Leukemia Cells

(2010) Ping Li et al.   PLoS One

B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

(2008) J. A. Burger et al.   BLOOD

Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation

(2008) S. K. Dissanayake et al.   CANCER RESEARCH

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

(2008) T. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA