Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

(2016) B. Cui et al.   BLOOD

Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation

(2016) Xiaoyuan Qi et al.   GENES TO CELLS

Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia

(2016) Elisa ten Hacken et al.   JOURNAL OF IMMUNOLOGY

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib

(2016) J Yu et al.   LEUKEMIA

Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1

(2015) Michael Y. Choi et al.   Clinical Lymphoma Myeloma & Leukemia

Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation

(2015) Jian Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells

(2015) Suranjana Mukherjee et al.   PLoS One

SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells

(2014) Marcus Lettau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia

(2013) E. ten Hacken et al.   BLOOD

ROR1 can interact with TCL1 and enhance leukemogenesis in E -TCL1 transgenic mice

(2013) G. F. Widhopf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Actin Regulatory Protein HS1 Interacts with Arp2/3 and Mediates Efficient Neutrophil Chemotaxis

(2012) Peter J. Cavnar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High expression of hematopoietic cell specific Lyn substrate-1 (HS1) predicts poor survival of B-cell chronic lymphocytic leukemia patients

(2012) Aleksandra Butrym et al.   LEUKEMIA RESEARCH

Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF–triggered granulopoiesis

(2012) Julia Skokowa et al.   NATURE MEDICINE

HS1, a Lyn Kinase Substrate, Is Abnormally Expressed in B-Chronic Lymphocytic Leukemia and Correlates with Response to Fludarabine-Based Regimen

(2012) Federica Frezzato et al.   PLoS One

Hematopoietic Lineage Cell-Specific Protein 1 Functions in Concert with the Wiskott-Aldrich Syndrome Protein To Promote Podosome Array Organization and Chemotaxis in Dendritic Cells

(2011) D. A. Klos Dehring et al.   JOURNAL OF IMMUNOLOGY

ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia

(2011) H. Elizabeth Broome et al.   LEUKEMIA RESEARCH

HS1 has a central role in the trafficking and homing of leukemic B cells

(2010) C. Scielzo et al.   BLOOD

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

(2010) Julie A Di Paolo et al.   Nature Chemical Biology

Unique Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Human B-Cell Chronic Lymphocytic Leukemia

(2008) S. Baskar et al.   CLINICAL CANCER RESEARCH

Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy

(2008) Amir H. DaneshManesh et al.   INTERNATIONAL JOURNAL OF CANCER

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

(2008) T. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt5a Control of Cell Polarity and Directional Movement by Polarized Redistribution of Adhesion Receptors

(2008) E. S. Witze et al.   SCIENCE