Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function

SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis

(2019) Yuanzhen Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

(2018) Baigalmaa Lkhagva et al.   Epigenetics

Integrative analysis of genome-wide lncRNA and mRNA expression in newly synthesized Brassica hexaploids

(2018) Ruihua Wang et al.   Ecology and Evolution

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

(2017) Yuxun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II: At the Crossroads

(2017) Ayenachew Bezawork-Geleta et al.   TRENDS IN BIOCHEMICAL SCIENCES

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression

(2016) Robert Jones et al.   BLOOD

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

(2016) Lei Li et al.   Nature Communications

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

(2016) Jae Ho Seo et al.   PLOS BIOLOGY

NADP+-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance

(2015) Feng Li et al.   MOLECULAR CELL

Mitochondrial Efficiency-Dependent Viability of Saccharomyces cerevisiae Mutants Carrying Individual Electron Transport Chain Component Deletions

(2015)   MOLECULES AND CELLS

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

(2015) J Pfleger et al.   Cell Death & Disease

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation

(2015) Anjali K. Nath et al.   Cell Reports

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion

(2015) Dayana B. Rivadeneira et al.   Science Signaling

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

(2014) Rebeca Acín-Pérez et al.   Cell Metabolism

Powerhouse down: Complex II dissociation in the respiratory chain

(2014) Ming-Shih Hwang et al.   MITOCHONDRION

Lysine Propionylation Is a Prevalent Post-translational Modification inThermus thermophilus

(2014) Hiroki Okanishi et al.   MOLECULAR & CELLULAR PROTEOMICS

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Alternative splicing isoform in succinate dehydrogenase complex, subunit C causes downregulation of succinate-coenzyme Q oxidoreductase activity in mitochondria

(2014) NANA SATOH et al.   Oncology Letters

Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis

(2014) Travis Hartman et al.   PLoS Pathogens

Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors

(2013) Bora E. Baysal   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel

(2013) Andrew P. Wojtovich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning

(2013) Stefan Dröse   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

(2013) Maria Damiano et al.   HUMAN MOLECULAR GENETICS

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity

(2013) Kristen P. Nickens et al.   MITOCHONDRION

Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB inEscherichia coli

(2013) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

(2013) Jeongsoon Park et al.   MOLECULAR CELL

Hypoxia-inducible C-to-U coding RNA editing downregulatesSDHBin monocytes

(2013) Bora E. Baysal et al.   PeerJ

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Respiratory chain complex II as general sensor for apoptosis

(2012) Stefan Grimm   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of complex II in disease

(2012) Attje S. Hoekstra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

(2012) A. Galmozzi et al.   DIABETES

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

(2011) Ji Zhang et al.   Cell Metabolism

Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane

(2011) Natalia Gebert et al.   MOLECULAR CELL

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

(2011) Lydia W. S. Finley et al.   PLoS One

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Advantage of Upregulation of Succinate Dehydrogenase in Staphylococcus aureus Biofilms

(2010) R. Gaupp et al.   JOURNAL OF BACTERIOLOGY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

Identification of lysine succinylation as a new post-translational modification

(2010) Zhihong Zhang et al.   Nature Chemical Biology

Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian Mitochondria

(2009) Huseyin Cimen et al.   BIOCHEMISTRY

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit

(2009) Eriko TOMITSUKA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The Hfq-Dependent Small Noncoding RNA NrrF Directly Mediates Fur-Dependent Positive Regulation of Succinate Dehydrogenase in Neisseria meningitidis

(2008) M. M. E. Metruccio et al.   JOURNAL OF BACTERIOLOGY

Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells

(2008) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY