Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

Mapping the Azolog Space Enables the Optical Control of New Biological Targets

(2019) Johannes Morstein et al.   ACS Central Science

Substituent Effects on 3-Arylazoindole Photoswitches

(2019) Nadja A. Simeth et al.   JOURNAL OF ORGANIC CHEMISTRY

Azologization of serotonin 5-HT3 receptor antagonists

(2019) Karin Rustler et al.   Beilstein Journal of Organic Chemistry

A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

(2019) Niels J. Hauwert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heteroaryl azo dyes as molecular photoswitches

(2019) Stefano Crespi et al.   Nature Reviews Chemistry

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions

(2018) Dina Robaa et al.   CHEMICAL RECORD

Restoring Vision to the Blind with Chemical Photoswitches

(2018) Ivan Tochitsky et al.   CHEMICAL REVIEWS

In Vivo Photopharmacology

(2018) Katharina Hüll et al.   CHEMICAL REVIEWS

Nitrogen-Containing, Light-Absorbing Oligomers Produced in Aerosol Particles Exposed to Methylglyoxal, Photolysis, and Cloud Cycling

(2018) David O. De Haan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Photoswitchable double bonds: Synthetic strategies for tunability and versatility

(2018) David Cameron et al.   JOURNAL OF PHYSICAL ORGANIC CHEMISTRY

New chemical tools for probing activity and inhibition of the NAD + -dependent lysine deacylase sirtuin 2

(2018) Sören Swyter et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Reversible, Spatial and Temporal Control over Protein Activity Using Light

(2018) Mark W.H. Hoorens et al.   TRENDS IN BIOCHEMICAL SCIENCES

First-Principles Prediction of Wavelength-Dependent Product Quantum Yields

(2018) Travis Thompson et al.   Journal of Physical Chemistry Letters

Tuning the photoreactivity of Z-hexatriene photoswitches by substituents – a non-adiabatic molecular dynamics study

(2018) Enrico Tapavicza et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure–Activity Relationship Analysis

(2017) Shenzhen Huang et al.   Journal of Chemical Information and Modeling

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

(2017) Sandeep Sundriyal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

(2017) Matthias Schiedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

(2017) Matthias Schiedel et al.   MEDICINAL RESEARCH REVIEWS

The role of tachysterol in vitamin D photosynthesis – a non-adiabatic molecular dynamics study

(2017) Cecilia Cisneros et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

(2016) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Emerging Targets in Photopharmacology

(2016) Michael M. Lerch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ablation of SIRT3 causes coronary microvascular dysfunction and impairs cardiac recovery post myocardial ischemia

(2016) Xiaochen He et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

(2016) Yi Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Importance of Vibronic Effects in the UV–Vis Spectrum of the 7,7,8,8-Tetracyanoquinodimethane Anion

(2016) Enrico Tapavicza et al.   Journal of Chemical Theory and Computation

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure–Activity Relationship Study

(2016) Matthias Schiedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors

(2016) Teng Ai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclohexadiene Revisited: A Time-Resolved Photoelectron Spectroscopy and ab Initio Study

(2016) Oliver Schalk et al.   JOURNAL OF PHYSICAL CHEMISTRY A

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine

(2014) Matthias Schoenberger et al.   ACS Chemical Neuroscience

Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach

(2014) Huaqing Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

(2014) C. Falenczyk et al.   Chemical Science

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

High-Contrast On/Off Fluorescence Switching via Reversible E–Z Isomerization of Diphenylstilbene Containing the α-Cyanostilbenic Moiety

(2013) Jong Won Chung et al.   Journal of Physical Chemistry C

Solvent Effects on Electronically Excited States Using the Conductor-Like Screening Model and the Second-Order Correlated Method ADC(2)

(2012) Bernd Lunkenheimer et al.   Journal of Chemical Theory and Computation

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

Photoisomerization in different classes of azobenzene

(2011) H. M. Dhammika Bandara et al.   CHEMICAL SOCIETY REVIEWS

Assessing Excited State Methods by Adiabatic Excitation Energies

(2011) Robert Send et al.   Journal of Chemical Theory and Computation

Re-investigation and Data Assessment of the Isomerization and 2,2′-Cyclization of Stilbenes and Azobenzenes†

(2009) Heiko K. Cammenga et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH