SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect

Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation

(2019) Victoria Cotero et al.   Nature Communications

Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis

(2019) Daniel P. Zachs et al.   Nature Communications

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

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Transcranial Ultrasound Stimulation Improves Long-Term Functional Outcomes and Protects Against Brain Damage in Traumatic Brain Injury

(2018) Szu-Fu Chen et al.   MOLECULAR NEUROBIOLOGY

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

(2018) M.J. McAllister et al.   OSTEOARTHRITIS AND CARTILAGE

The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

(2018) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats

(2018) Nobuyuki Itaya et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

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Autophagy limits activation of the inflammasomes

(2017) Michihiro Takahama et al.   IMMUNOLOGICAL REVIEWS

LIPUS suppressed LPS-induced IL-1α through the inhibition of NF-κB nuclear translocation via AT1-PLCβ pathway in MC3T3-E1 cells

(2017) Mayu Nagao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibitory Effect of Low-Intensity Pulsed Ultrasound on the Expression of Lipopolysaccharide-Induced Inflammatory Factors in U937 Cells

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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Parkin Regulates the Activity of Pyruvate Kinase M2

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Molecular imaging detects activated macrophages

(2016) Sarah Onuora   Nature Reviews Rheumatology

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Efficacy of focused low-intensity pulsed ultrasound therapy for the management of knee osteoarthritis: a randomized, double blind, placebo-controlled trial

(2016) Lang Jia et al.   Scientific Reports

Synovial tissue volume: a treatment target in knee osteoarthritis (OA)

(2015) Terence W O'Neill et al.   ANNALS OF THE RHEUMATIC DISEASES

The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

(2015) Rosa Viana et al.   BMC BIOCHEMISTRY

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

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Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1  expression

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Depletion of Protease-Activated Receptor 2 but Not Protease-Activated Receptor 1 May Confer Protection Against Osteoarthritis in Mice Through Extracartilaginous Mechanisms

(2014) Miriam T. Jackson et al.   Arthritis & Rheumatology

The Warburg effect then and now: From cancer to inflammatory diseases

(2013) Eva M. Palsson-McDermott et al.   BIOESSAYS

Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4–MyD88 dissociation

(2013) Juna Nakao et al.   BONE

SQSTM1/p62/A170 regulates the severity ofLegionella pneumophilapneumonia by modulating inflammasome activity

(2013) Shigeo Ohtsuka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Progress in intra-articular therapy

(2013) Christopher H. Evans et al.   Nature Reviews Rheumatology

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254)

(2012) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

(2011) Tom M. Piscaer et al.   ARTHRITIS AND RHEUMATISM

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate

(2011) Y. Watanabe et al.   JOURNAL OF CELL SCIENCE

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI

(2010) F.W. Roemer et al.   OSTEOARTHRITIS AND CARTILAGE

Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation

(2009) Alexandra Kadl et al.   ARTHRITIS AND RHEUMATISM

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease

(2007) Hisako Hikiji et al.   PROGRESS IN LIPID RESEARCH