A Probiotic Spore‐Based Oral Autonomous Nanoparticles Generator for Cancer Therapy

Engineered Bacterial Bioreactor for Tumor Therapy via Fenton-Like Reaction with Localized H2 O2 Generation

(2019) Jin-Xuan Fan et al.   ADVANCED MATERIALS

Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin

(2018) Yining Xu et al.   ACS Applied Materials & Interfaces

Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer

(2018) Bo Xiao et al.   ACS Nano

Enzyme decorated drug carriers: Targeted swords to cleave and overcome the mucus barrier

(2018) Claudia Menzel et al.   ADVANCED DRUG DELIVERY REVIEWS

Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery

(2018) Weiwei Fan et al.   BIOMATERIALS

Combinational strategy for high-performance cancer chemotherapy

(2018) Si-Yong Qin et al.   BIOMATERIALS

Development of a theranostic prodrug for colon cancer therapy by combining ligand-targeted delivery and enzyme-stimulated activation

(2018) Amit Sharma et al.   BIOMATERIALS

Current pharmaceutical strategies for efficient site specific delivery in inflamed distal intestinal mucosa

(2018) Sumit Sharma et al.   JOURNAL OF CONTROLLED RELEASE

Hypoxia-specific therapeutic agents delivery nanotheranostics: A sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer

(2018) Qianhua Feng et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced oral absorption and anticancer efficacy of cabazitaxel by overcoming intestinal mucus and epithelium barriers using surface polyethylene oxide (PEO) decorated positively charged polymer-lipid hybrid nanoparticles

(2018) Tianyang Ren et al.   JOURNAL OF CONTROLLED RELEASE

Bacillus spore-based oral carriers loading curcumin for the therapy of colon cancer

(2018) Liang Yin et al.   JOURNAL OF CONTROLLED RELEASE

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

(2018) Jutaek Nam et al.   Nature Communications

Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin

(2018) Houkuan Tian et al.   Advanced Healthcare Materials

Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway

(2018) Yaxian Zheng et al.   ACS Applied Materials & Interfaces

Transport Mechanisms of Butyrate Modified Nanoparticles: Insight into “Easy Entry, Hard Transcytosis” of Active Targeting System in Oral Administration

(2018) Lei Wu et al.   MOLECULAR PHARMACEUTICS

Large-Pore Mesoporous-Silica-Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy

(2018) Binbin Ding et al.   ADVANCED MATERIALS

Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis

(2018) Wantong Song et al.   ADVANCED MATERIALS

Starch- and carboxymethylcellulose-coated bacterial nanocellulose-pectin bionanocomposite as novel protective prebiotic matrices

(2017) Alireza Chackoshian Khorasani et al.   FOOD HYDROCOLLOIDS

In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers

(2017) Rui Wang et al.   Nature Communications

The combination of endolysosomal escape and basolateral stimulation to overcome the difficulties of “easy uptake hard transcytosis” of ligand-modified nanoparticles in oral drug delivery

(2017) Yi Cui et al.   Nanoscale

Sub-50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier

(2016) Xi Zhu et al.   ADVANCED FUNCTIONAL MATERIALS

Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome

(2016) Aaron C. Anselmo et al.   ADVANCED MATERIALS

Intracellular transport of nanocarriers across the intestinal epithelium

(2016) Weiwei Fan et al.   DRUG DISCOVERY TODAY

Bacterial spores as particulate carriers for gene gun delivery of plasmid DNA

(2016) Luana R.M.M. Aps et al.   JOURNAL OF BIOTECHNOLOGY

Efficient mucus permeation and tight junction opening by dissociable “mucus-inert” agent coated trimethyl chitosan nanoparticles for oral insulin delivery

(2016) Min Liu et al.   JOURNAL OF CONTROLLED RELEASE

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

(2016) Amrita Banerjee et al.   JOURNAL OF CONTROLLED RELEASE

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

(2015) Qingguo Xu et al.   ACS Nano

Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT)

(2015) Elisa Lozano et al.   JOURNAL OF CONTROLLED RELEASE

A versatile nano display platform from bacterial spore coat proteins

(2015) I-Lin Wu et al.   Nature Communications

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

(2014) Jung Soo Suk et al.   JOURNAL OF CONTROLLED RELEASE

Structural basis of the alternating-access mechanism in a bile acid transporter

(2013) Xiaoming Zhou et al.   NATURE

Bacterial spores as platforms for bioanalytical and biomedical applications

(2011) Leslie D. Knecht et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Adsorption immobilization of Escherichia coli phytase on probiotic Bacillus polyfermenticus spores

(2011) Eun-Ah Cho et al.   ENZYME AND MICROBIAL TECHNOLOGY

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles

(2008) HouLi Li et al.   JOURNAL OF CONTROLLED RELEASE