Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies – current issues and future directions

(2019) Lauren Walker et al.   JOURNAL OF NEUROCHEMISTRY

Translational control in brain pathologies: biological significance and therapeutic opportunities

(2019) Alberto Delaidelli et al.   ACTA NEUROPATHOLOGICA

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

α-Synuclein promotes dilation of the exocytotic fusion pore

(2017) Todd Logan et al.   NATURE NEUROSCIENCE

A Primer on Concepts and Applications of Proteomics in Neuroscience

(2017) Fabian Hosp et al.   NEURON

Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

(2017) Joori Park et al.   Nature Communications

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer’s Disease

(2016) Brenna C. Beckelman et al.   JOURNAL OF ALZHEIMERS DISEASE

Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

(2016) Ye Jin Chai et al.   JOURNAL OF CELL BIOLOGY

 -Synuclein Mutation Inhibits Endocytosis at Mammalian Central Nerve Terminals

(2016) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Synaptic failure and α-synuclein

(2016) Laura Calo et al.   MOVEMENT DISORDERS

Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum

(2016) Masatake Fujimura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Structural basis of synaptic vesicle assembly promoted by α-synuclein

(2016) Giuliana Fusco et al.   Nature Communications

Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts

(2016) Marco Emanuele et al.   EBioMedicine

Mitochondrial dysfunction in Parkinson’s disease

(2016) Qingsong Hu et al.   Translational Neurodegeneration

α-Synuclein is a Novel Microtubule Dynamase

(2016) Daniele Cartelli et al.   Scientific Reports

Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity

(2015) Daniela C. Dieterich et al.   MOLECULAR & CELLULAR PROTEOMICS

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections

(2015) Wasim Abbas et al.   Frontiers in Oncology

Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

(2014) Christoph Biesemann et al.   EMBO JOURNAL

The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

(2014) Nicoletta Plotegher et al.   HUMAN MOLECULAR GENETICS

β-III Tubulin Fragments Inhibit α-Synuclein Accumulation in Models of Multiple System Atrophy

(2014) Yasuyo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

Calcineurin determines toxic versus beneficial responses to  -synuclein

(2014) G. Caraveo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

(2013) David Amschl et al.   BMC NEUROSCIENCE

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons

(2013) Guangwei Liu et al.   JOURNAL OF NEURAL TRANSMISSION

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance

(2013) Laurie D. Cohen et al.   PLoS One

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

From α-synuclein to synaptic dysfunctions: New insights into the pathophysiology of Parkinson's disease

(2012) Arianna Bellucci et al.   BRAIN RESEARCH

Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones

(2012) Masumi Iketani et al.   Developmental Neurobiology

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

(2012) C. Kilkenny et al.   OSTEOARTHRITIS AND CARTILAGE

Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy

(2011) Kimiko Nakayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Imaging of Intersynaptic Vesicle Exchange Using VGLUT1Venus Knock-In Mice

(2011) E. Herzog et al.   JOURNAL OF NEUROSCIENCE

Neurite Outgrowth Mediated by Translation Elongation Factor eEF1A1: A Target for Antiplatelet Agent Cilostazol

(2011) Kenji Hashimoto et al.   PLoS One

eEF1A: Thinking Outside the Ribosome

(2010) Maria K. Mateyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

(2009) Esperanza Fernández et al.   Molecular Systems Biology

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC