The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity

Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells

(2014) N. Plotegher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity

(2014) Nicoletta Plotegher et al.   QUARTERLY REVIEWS OF BIOPHYSICS

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

The many faces of alpha-synuclein mutations

(2013) Meike Kasten et al.   MOVEMENT DISORDERS

α-Synuclein mutations cluster around a putative protein loop

(2013) Eleanna Kara et al.   NEUROSCIENCE LETTERS

Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations

(2013) Andreas Puschmann   PARKINSONISM & RELATED DISORDERS

Atomic Force Microscopy under Controlled Conditions Reveals Structure of C-Terminal Region of α-Synuclein in Amyloid Fibrils

(2012) Kim K. M. Sweers et al.   ACS Nano

Molecular Composition of Sub-stoichiometrically Labeled α-Synuclein Oligomers Determined by Single-Molecule Photobleaching

(2012) Niels Zijlstra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Structure-oriented review of 14-3-3 protein isoforms in geriatric neuroscience

(2012) Takahiko Umahara et al.   Geriatrics & Gerontology International

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans

(2012) Martin L. Duennwald et al.   PLOS BIOLOGY

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP

(2011) Alexander Kurz et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Confocal Fluorescence Anisotropy and FRAP Imaging of α-Synuclein Amyloid Aggregates in Living Cells

(2011) M. Julia Roberti et al.   PLoS One

Observation of spatial propagation of amyloid assembly from single nuclei

(2011) T. P. J. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the proteome: disordered and alternatively folded proteins

(2011) H. Jane Dyson   QUARTERLY REVIEWS OF BIOPHYSICS

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

(2010) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Interaction of αB-Crystallin with Mature α-Synuclein Amyloid Fibrils Inhibits Their Elongation

(2010) Christopher A. Waudby et al.   BIOPHYSICAL JOURNAL

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel, high-efficiency cellular model of fibrillar α-synuclein inclusions and the examination of mutations that inhibit amyloid formation

(2010) Elisa A. Waxman et al.   JOURNAL OF NEUROCHEMISTRY

Countering amyloid polymorphism and drug resistance with minimal drug cocktails

(2010) Martin L. Duennwald et al.   Prion

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

(2010) T A Yacoubian et al.   Cell Death & Disease

Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization

(2009) Elisa A. Waxman et al.   BIOCHEMISTRY

Structural Properties of Pore-Forming Oligomers of α-Synuclein

(2009) Hai-Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Parkinson's disease: emerging role of molecular chaperones

(2009) Rina Bandopadhyay et al.   TRENDS IN MOLECULAR MEDICINE

Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly†

(2008) Kelvin C. Luk et al.   BIOCHEMISTRY

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein

(2007) Kazuya Omi et al.   NEUROSCIENCE LETTERS