Article
Immunology
Xiangming Liu, Yiming Ma, Lijuan Luo, Zihang Zeng, Dandan Zong, Yan Chen
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation and lung parenchymal cell apoptosis, with cigarette smoke being the major risk factor. In this study, taxifolin (TAX) was found to significantly alleviate cigarette smoke-induced inflammation and apoptosis in vivo and in vitro. TAX treatment suppressed the elevated levels of IL-1 beta, IL-6, and TNF-alpha, and decreased the ratios of p-i kappa B to i kappa B and p-p65 to p65. Additionally, TAX exhibited antiapoptotic effects by reversing the changes in Bax, CCP3, and Bcl-2 levels induced by cigarette smoke. These findings highlight the potential of TAX in improving COPD pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Lifang Li, Yaqian Zhang, Jiannan Gong, Guang Yang, Shuyin Zhi, Dongping Ren, Hui Zhao
Summary: The study aimed to determine the expression of Cpt1a in the lung tissue of COPD patients and its correlation with lung function. Increased Cpt1a expression improved lung function in patients with COPD by inhibiting apoptosis and inflammation in lung endothelial cells. In vivo and in vitro experiments confirmed that Cpt1a attenuated lung dysfunction in COPD by inhibiting endothelial cell apoptosis and inflammatory responses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shuang Bai, Rui Ye, Cuihong Wang, Pengbo Sun, Di Wang, Yong Yue, Huiying Wang, Si Wu, Miao Yu, Shuhua Xi, Li Zhao
Summary: This study identified differential protein expression in COPD patients with emphysematous phenotype, indicating that KRT17 and DHRS9 are potentially involved in wound healing and retinol metabolism pathways. GO and KEGG analyses highlighted the importance of these pathways in the molecular mechanism of COPD emphysematous phenotype.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
Vivek Vardhan Veerapaneni, Swapna Upadhyay, Tania A. Thimraj, Jayaraj Biligere Siddaiah, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Rajesh Thimmulappa, Lena Palmberg, Koustav Ganguly, Mahesh Padukudru Anand
Summary: The study found that decreased levels of SCGB1A1 protein were associated with BMS-COPD and TS-COPD patients, positively correlated with indicators like respiratory function and exercise capacity, and decreased with severity of COPD, dyspnea, and other indicators.
Article
Respiratory System
David A. Skerrett-Byrne, Elizabeth G. Bromfield, Heather C. Murray, M. Fairuz B. Jamaluddin, Andrew G. Jarnicki, Michael Fricker, Ama T. Essilfie, Bernadette Jones, Tatt J. Haw, Daniel Hampsey, Amanda L. Anderson, Brett Nixon, Rodney J. Scott, Peter A. B. Wark, Matthew D. Dun, Philip M. Hansbro
Summary: The study utilized proteomics to uncover major protein changes associated with the pathogenesis and disease progression of COPD, including alterations in RNA biosynthesis, inflammatory responses, mitochondrial function, and oxidative stress. These changes provide insight for developing new effective treatment strategies.
Review
Cell Biology
John W. Hanrahan, Asmahan Abu-Arish, Francis H. Wong, Mark J. Turner, Graeme W. Carlile, David Y. Thomas, Andre M. Cantin
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death, with cigarette smoke being the main risk factor. COPD shares similarities with cystic fibrosis (CF), particularly in terms of inflammation, mucus obstruction, and infection. Understanding the effects of cigarette smoke on CFTR function may lead to the development of novel therapeutics for reducing the progression and severity of COPD.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Environmental Sciences
Priya Upadhyay, Ching-Wen Wu, Alexa Pham, Amir A. Zeki, Christopher M. Royer, Urmila P. Kodavanti, Minoru Takeuchi, Hasan Bayram, Kent E. Pinkerton
Summary: Chronic obstructive pulmonary disease (COPD) is a major cause of mortality globally, characterized by lung damage, inflammation, and airflow obstruction. Tobacco smoking is the primary cause, but exposure to air pollutants and workplace fumes also contribute. Animal models have helped to improve our understanding of COPD pathogenesis and potential treatments.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao
Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Biochemistry & Molecular Biology
Megan E. Huber, Emily Larson, Taylor N. Lust, Chelsea M. Heisler, Melanie J. Harriff
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation, increased infiltration of CD81 T lymphocytes, and infection-driven exacerbations. The role of lung-resident mucosal-associated invariant T (MAIT) cells in COPD pathology is unclear. This study found that MAIT cell activation is dysregulated in response to cigarette smoke and COPD, potentially contributing to inflammation and impaired bacterial recognition, leading to microbial persistence and COPD exacerbations.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Food Science & Technology
Sun Young Jung, Gun-Dong Kim, Dae Woon Choi, Dong-Uk Shin, Ji-Eun Eom, Seung Yong Kim, Ok Hee Chai, Hyun-Jin Kim, So-Young Lee, Hee Soon Shin
Summary: The study found that Epilobium species extract can inhibit inflammatory cell recruitment and symptoms in COPD mice, as well as attenuate inflammatory gene expression by suppressing MAPKs and NF kappa B activity. Additionally, identified phytochemical constituents of Epilobium species extract showed anti-inflammatory effects.
Article
Chemistry, Medicinal
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
Summary: This study aimed to explore the protective mechanisms of green tea extract (GTE) on cigarette smoke condensate (CSC)-induced emphysema by reducing macrophage-induced protease expression. Results showed that GTE significantly reduced macrophage counts and emphysematous lesions in CSC-exposed mice. Furthermore, GTE suppressed CSC-induced ERK/AP-1 phosphorylation and MMP-9 expression. These findings suggest that GTE can be used as a supplementary agent for preventing emphysema progression in COPD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Huimiao Ma, Ziye Zhou, Lanying Chen, Lingling Wang, Qi Muge
Summary: Anemoside B4 can alleviate CS-induced inflammation in COPD and prevent basal cell hyperplasia. It exerts its anti-inflammatory effects by inhibiting oxidative stress response, reducing the production of inflammatory cytokines, and regulating protein expression in the MAPK/AP-1/TGF-β signaling pathway.
Review
Biochemistry & Molecular Biology
Maria-Elpida Christopoulou, Eleni Papakonstantinou, Daiana Stolz
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Elida Duenas-Meza, Luis F. Giraldo-Cadavid, Elizabeth Karpf, Felipe Afanador, Olga L. Angarita, Oscar Baron, Maria S. Medina, Angelica F. T. Pachon, Angelica Gonzalez, Jenny Jurado, Carlos A. Torres-Duque
PEDIATRIC PULMONOLOGY
(2020)
Article
Physiology
Mauricio Gonzalez-Garcia, Dario Maldonado, Margarita Barrero, Alejandro Casas, Rogelio Perez-Padilla, Carlos A. Torres-Duque
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Clinical Neurology
Elida Duenas-Meza, Maria Isabel Escamilla-Gil, Maria Angelica Bazurto-Zapata, Elizabeth Caparo, Miguel Suarez Cuartas, Laura Rincon Martinez, Lizbeth Pernett Buenaver, Ariana Rojas Ortega, Jorge Torres, Sonia Restrepo-Gualteros, Andrea Parra Buitrago, Mauricio Gonzalez-Garcia
Summary: This study found that preterm infants born at high altitudes have a greater impact on oxygen saturation and intermittent hypoxia during sleep compared to full-term infants. These preterm infants have a higher rate of respiratory events and lower oxygen saturation, indicating the need for timely diagnosis and treatment of respiratory disturbances during sleep.
Article
Physiology
Mauricio Gonzalez-Garcia, Margarita Barrero, Dario Maldonado
Summary: This study aimed to compare exercise capacity, gas exchange, ventilatory alterations, and symptoms in COPD patients at the altitude of Bogota. The main findings were a progressive decrease in exercise capacity, increased dyspnea, dynamic hyperinflation, restrictive mechanical constraints, and gas exchange abnormalities during exercise, across GOLD stages 1-4. Compared with studies at sea level, hypoxemia at rest and during exercise was more severe at high altitude.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Mauricio Gonzalez-Garcia, Emily Rincon-Alvarez, Maria Laura Alberti, Mauricio Duran, Fabian Caro, Maria del Carmen Venero, Yuri Edison Liberato, Ivette Buendia-Roldan
Summary: This study investigated comorbidities in IPF patients in four Latin American countries, revealing significant differences between countries and a higher prevalence of pulmonary hypertension in subjects residing in cities at higher altitudes.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Carlos A. Torres-Duque, Jaime Ocampo-Gomez, Mauricio Morales Castillo, Diana Cano-Rosales, Angela Giraldo-Montoya, Freddy Rodriguez, Isabel Palacios-Ortega, Mauricio Duran-Silva, Humberto Reynales, Elizabeth Garcia
Summary: This study aimed to evaluate the real-world effectiveness of omalizumab in adult and pediatric patients with severe allergic asthma in Colombia. The results showed a significant reduction in the risk of clinically significant asthma exacerbations with the use of omalizumab.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Abraham Ali-Munive, Prada Leidy, Nadia Juliana Proanos, John Pedrozo-Pupo, Angela Giraldo, Diana Cano, Claudia Diaz-Bossa, Ricardo Mosquera, Hector Paul, Mauricio Gonzalez-Garcia, Carlos Aguirre-Franco, Jose Luis Lopez-Campos, Alejandro Casas-Herrera
Summary: This study investigated the prevalence of alpha-1 antitrypsin deficiency (AATD) in adult patients with COPD in Colombia. The results showed that 13.01% of the patients had genetic mutations, with 2.07% being AATD-related. The importance of assessing AATD in COPD patients was highlighted.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Emily Rincon-Alvarez, Mauricio Gonzalez-Garcia, Abraham Ali-Munive, Alejandro Casas, Nadia Juliana Proanos, Luis Fernando Giraldo-Cadavid, Angelica Moreno, Carolina Perez, Wendy Rubiano, Mary Cogollo, Patricia Parada-Tovar, Carlos A. Torres-Duque
Summary: This study evaluated the CT, clinical, and functional involvement in survivors with moderate-severe COVID-19 at 3 and 6 months post-hospitalization in high-altitude areas. At 6 months, 33.5% of patients had abnormal lung CT, and these patients experienced more dyspnea and lower exercise SpO(2). Despite the persistence of CT abnormalities, lung function and the 6-minute walk test improved. The variables associated with abnormal lung CT were identified.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Nadia Juliana Proanos, Mauricio Gonzalez-Garcia, Dayan Crispin-Cruz, Abraham Ali-Munive, Juan Carlos Villar, Carlos A. Torres-Duque, Alejandro Casas
Summary: This study aimed to compare the level of knowledge in vaccination against influenza and pneumococcus of COPD patients managed in an Integrated Care Program with those who receive usual care. The study found that COPD patients in the Integrated Care Program had a higher level of vaccination knowledge compared to those in usual care.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Respiratory System
Mayson Laercio de Araujo Sousa, Iara S. Shimizu, Cecilia M. Patino, Carlos A. Torres-Duque, Ignacio Zabert, Gustavo E. Zabert, Rogelio Perez-Padilla, Fabio Varon-Vega, Mark Cohen, Juliana C. Ferreira
Summary: This study evaluated the knowledge, attitudes, and practices of healthcare workers in Latin American countries during the initial surge of the COVID-19 pandemic. The findings showed that nearly half of the healthcare workers had a low COVID-19 knowledge score, and the level of knowledge was associated with the type of institution, participation in institutional training, and information sources. Most healthcare workers were concerned about not being able to provide adequate care to patients.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Respiratory System
Mauricio Gonzalez-Garcia, Carlos Eduardo Aguirre-Franco, Leslie Vargas-Ramirez, Margarita Barrero, Carlos A. Torres-Duque
Summary: Pulmonary hypertension (PH) is associated with decreased exercise tolerance and altered gas exchange in chronic obstructive pulmonary disease (COPD) patients. The presence of PH has an independent impact on exercise capacity in COPD patients residing at high altitude.
CHRONIC RESPIRATORY DISEASE
(2022)
Meeting Abstract
Clinical Neurology
Elida Duenas-Meza, Maria Escamilla, Laura Rincon, Andrea Parra, Maria Bazurto-Zapata, Sonia Restrepo, Jorge Luis Torres, Miguel Suarez, Arriana Rojas, Elizabeth Caparo, Mauricio Gonzalez-Garcia