Computational Methods for the Discovery of Metabolic Markers of Complex Traits

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Visible Machine Learning for Biomedicine

(2018) Michael K. Yu et al.   CELL

A classification modeling approach for determining metabolite signatures in osteoarthritis

(2018) Jason S. Rockel et al.   PLoS One

An evolutionary learning and network approach to identifying key metabolites for osteoarthritis

(2018) Ting Hu et al.   PLoS Computational Biology

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

Application of Metabolomics in Alzheimer’s Disease

(2018) Jordan Maximillian Wilkins et al.   Frontiers in Neurology

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data

(2017) Fadhl M. Alakwaa et al.   JOURNAL OF PROTEOME RESEARCH

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

(2017) Jun Liu et al.   Metabolomics

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A decade after the metabolomics standards initiative it's time for a revision

(2017) Rachel A. Spicer et al.   Scientific Data

Introduction to metabolomics and its applications in ophthalmology

(2016) S Z Tan et al.   EYE

Mastering the game of Go with deep neural networks and tree search

(2016) David Silver et al.   NATURE

Emerging applications of metabolomics in drug discovery and precision medicine

(2016) David S. Wishart   NATURE REVIEWS DRUG DISCOVERY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients

(2016) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

A tutorial review: Metabolomics and partial least squares-discriminant analysis – a marriage of convenience or a shotgun wedding

(2015) Piotr S. Gromski et al.   ANALYTICA CHIMICA ACTA

Evolutionary algorithms for de novo drug design – A survey

(2015) R. Vasundhara Devi et al.   APPLIED SOFT COMPUTING

Mass spectrometry-based metabolomics: applications to biomarker and metabolic pathway research

(2015) Aihua Zhang et al.   BIOMEDICAL CHROMATOGRAPHY

False-negative rate of combined mammography and ultrasound for women with palpable breast masses

(2015) Carlos H. F. Chan et al.   BREAST CANCER RESEARCH AND TREATMENT

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine

(2015) R Kaddurah-Daouk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

(2015) Qingmeng Zhang et al.   DISEASE MARKERS

Novel methodologies for biomarker discovery in atherosclerosis

(2015) Imo E. Hoefer et al.   EUROPEAN HEART JOURNAL

Probabilistic machine learning and artificial intelligence

(2015) Zoubin Ghahramani   NATURE

Deep learning

(2015) Yann LeCun et al.   NATURE

Optimizing artificial neural network models for metabolomics and systems biology: an example using HPLC retention index data

(2015) L Mark Hall et al.   Bioanalysis

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Plasma Metabolite Profiles of Alzheimer’s Disease and Mild Cognitive Impairment

(2014) Gang Wang et al.   JOURNAL OF PROTEOME RESEARCH

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis

(2014) A.M. Valdes et al.   OSTEOARTHRITIS AND CARTILAGE

Classification of osteoarthritis phenotypes by metabolomics analysis

(2014) Weidong Zhang et al.   BMJ Open

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

(2012) Jianguo Xia et al.   Metabolomics

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

(2011) M. Hilvo et al.   CANCER RESEARCH

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Epidemiology of Osteoarthritis

(2010) Yuqing Zhang et al.   CLINICS IN GERIATRIC MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Analysis of Metabolomic Data Using Support Vector Machines

(2008) Sankar Mahadevan et al.   ANALYTICAL CHEMISTRY

Metabolomics: A Global Biochemical Approach to Drug Response and Disease

(2008) Rima Kaddurah-Daouk et al.   Annual Review of Pharmacology and Toxicology

Genetic algorithms for simultaneous variable and sample selection in metabonomics

(2008) Rachel Cavill et al.   BIOINFORMATICS

Genetic algorithm based two-mode clustering of metabolomics data

(2008) J. A. Hageman et al.   Metabolomics