Candida albicans Interactions with Mucosal Surfaces during Health and Disease

Plasma membrane architecture protects Candida albicans from killing by copper

(2019) Lois M. Douglas et al.   PLoS Genetics

Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses

(2019) Tzu-Yu Shao et al.   Cell Host & Microbe

Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection

(2019) Jessica N. Witchley et al.   Cell Host & Microbe

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

(2019) Shen-Huan Liang et al.   Cell Host & Microbe

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

(2019) Petra Bacher et al.   CELL

Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88

(2018) Claudia Ramos Pinheiro et al.   CYTOKINE

IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms

(2018) Akash H. Verma et al.   JOURNAL OF IMMUNOLOGY

Candida innate immunity at the mucosa

(2018) Jonathan P. Richardson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence

(2018) Jonathan P. Richardson et al.   mBio

Candida albicans -Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

(2018) Stefanie Allert et al.   mBio

Biphasic zinc compartmentalisation in a human fungal pathogen

(2018) Aaron C. Crawford et al.   PLoS Pathogens

Invasive candidiasis

(2018) Peter G. Pappas et al.   Nature Reviews Disease Primers

Experimental evolution of a fungal pathogen into a gut symbiont

(2018) Gloria Hoi Wan Tso et al.   SCIENCE

Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and Infections

(2017) Peter N. Lipke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Candida albicans possess a highly versatile and dynamic high-affinity iron transport system important for its commensal-pathogenic lifestyle

(2017) Zeinab Mamouei et al.   MOLECULAR MICROBIOLOGY

Candida and its dual lifestyle as a commensal and a pathogen

(2017) Mathieu Cauchie et al.   RESEARCH IN MICROBIOLOGY

The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis

(2017) Norma V. Solis et al.   mBio

Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis

(2017) Junko Yano et al.   mBio

Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition

(2017) Rohitashw Kumar et al.   Scientific Reports

Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses

(2017) Marc Swidergall et al.   PLoS Pathogens

Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans

(2017) Dhara Malavia et al.   Frontiers in Microbiology

EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans

(2017) Marc Swidergall et al.   Nature Microbiology

IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis

(2016) Heather R. Conti et al.   Cell Host & Microbe

Cell biology of Candida albicans –host interactions

(2016) Alessandra da Silva Dantas et al.   CURRENT OPINION IN MICROBIOLOGY

Candida albicans biofilms: development, regulation, and molecular mechanisms

(2016) Megha Gulati et al.   MICROBES AND INFECTION

Candidalysin is a fungal peptide toxin critical for mucosal infection

(2016) David L. Moyes et al.   NATURE

In vivoinduction of neutrophil chemotaxis by secretory aspartyl proteinases ofCandida albicans

(2016) Elena Gabrielli et al.   Virulence

Fungi in the healthy human gastrointestinal tract

(2016) Heather E. Hallen-Adams et al.   Virulence

Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function

(2016) Lois L. Hoyer et al.   Frontiers in Microbiology

Structural basis of haem-iron acquisition by fungal pathogens

(2016) Lena Nasser et al.   Nature Microbiology

Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier

(2016) Marianne Goyer et al.   PLoS One

Candida albicansis able to use M cells as a portal of entry across the intestinal barrierin vitro

(2015) Sandrine Albac et al.   CELLULAR MICROBIOLOGY

The Candida albicans agglutinin-like sequence family of adhesins: functional insights gained from structural analysis

(2015) Ernesto Cota et al.   Future Microbiology

New signaling pathways govern the host response toC. albicansinfection in various niches

(2015) Yaoping Liu et al.   GENOME RESEARCH

Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street

(2015) David M. Underhill et al.   IMMUNITY

β-Defensin 1 Plays a Role in Acute Mucosal Defense againstCandida albicans

(2015) Jeffrey Tomalka et al.   JOURNAL OF IMMUNOLOGY

Digestive tract mycobiota: A source of infection

(2015) N. Gouba et al.   MEDECINE ET MALADIES INFECTIEUSES

Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface

(2015) David L Moyes et al.   Virulence

Distinct stages during colonization of the mouse gastrointestinal tract by Candida albicans

(2015) Daniel Prieto et al.   Frontiers in Microbiology

Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

(2015) Ana Silva-Dias et al.   Frontiers in Microbiology

VulvovaginalCandida albicansinfections: pathogenesis, immunity and vaccine prospects

(2014) A Cassone   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The Peptide-binding Cavity Is Essential for Als3-mediated Adhesion ofCandida albicansto Human Cells

(2014) Jing Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral-resident natural Th17 cells and γδ T cells control opportunisticCandida albicansinfections

(2014) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Corneal Epithelial Cells Produce Antimicrobial Peptides LL-37 and β-Defensins in Response to Heat-Killed Candida albicans

(2014) Xia Hua et al.   OPHTHALMIC RESEARCH

The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans

(2014) Daniel Prieto et al.   PLoS One

Candida Vaginitis: When Opportunism Knocks, the Host Responds

(2014) Brian M. Peters et al.   PLoS Pathogens

A Relay Network of Extracellular Heme-Binding Proteins Drives C. albicans Iron Acquisition from Hemoglobin

(2014) Galit Kuznets et al.   PLoS Pathogens

Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis

(2014) Diana C. Rosentul et al.   Frontiers in Microbiology

A proposed mechanism for the interaction between the Candida albicans Als3 adhesin and streptococcal cell wall proteins

(2014) Lois L. Hoyer et al.   Frontiers in Microbiology

Candida albicans Mucin Msb2 Is a Broad-Range Protectant against Antimicrobial Peptides

(2013) Marc Swidergall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Candida albicans Flu1-Mediated Efflux of Salivary Histatin 5 Reduces Its Cytosolic Concentration and Fungicidal Activity

(2013) Rui Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Does Candida albicans Als5p Amyloid Play a Role in Commensalism in Caenorhabditis elegans?

(2013) Michael Bois et al.   EUKARYOTIC CELL

Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis

(2013) Junko Yano et al.   INFECTION AND IMMUNITY

Protection Against Epithelial Damage During Candida albicans Infection Is Mediated by PI3K/Akt and Mammalian Target of Rapamycin Signaling

(2013) David L. Moyes et al.   JOURNAL OF INFECTIOUS DISEASES

Prevalence of Recurrent Vulvovaginal Candidiasis in 5 European Countries and the United States

(2013) Betsy Foxman et al.   Journal of Lower Genital Tract Disease

Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

(2013) Kalyan Pande et al.   NATURE GENETICS

The emerging world of the fungal microbiome

(2013) Gary B. Huffnagle et al.   TRENDS IN MICROBIOLOGY

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

(2013) Jing Xie et al.   PLOS BIOLOGY

Candida albicans Commensalism and Pathogenicity Are Intertwined Traits Directed by a Tightly Knit Transcriptional Regulatory Circuit

(2013) J. Christian Pérez et al.   PLOS BIOLOGY

Interactions ofCandida albicanswith host epithelial surfaces

(2013) David W. Williams et al.   Journal of Oral Microbiology

Pathogenic Pore-Forming Proteins: Function and Host Response

(2012) Mirko Bischofberger et al.   Cell Host & Microbe

Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut

(2012) Janet Z. Liu et al.   Cell Host & Microbe

Insight into the Antiadhesive Effect of Yeast Wall Protein 1 of Candida albicans

(2012) Bruce L. Granger   EUKARYOTIC CELL

Beyond the wall:Candida albicanssecret(e)s to survive

(2012) Alice G. Sorgo et al.   FEMS MICROBIOLOGY LETTERS

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Evaluation of the Role of Candida albicans Agglutinin-Like Sequence (Als) Proteins in Human Oral Epithelial Cell Interactions

(2012) Celia Murciano et al.   PLoS One

EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection

(2012) W. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations

(2012) J. V. Pierce et al.   mBio

Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion

(2012) Francesco Citiulo et al.   PLoS Pathogens

An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis

(2011) Changbin Chen et al.   Cell Host & Microbe

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans

(2011) Lynn Ziegler et al.   MOLECULAR MICROBIOLOGY

Candida albicans morphogenesis and host defence: discriminating invasion from colonization

(2011) Neil A. R. Gow et al.   NATURE REVIEWS MICROBIOLOGY

Beta-defensins: what are they REALLY doing in the oral cavity?

(2011) G Diamond et al.   ORAL DISEASES

Human Antimicrobial Peptide LL-37 Inhibits Adhesion of Candida albicans by Interacting with Yeast Cell-Wall Carbohydrates

(2011) Pei-Wen Tsai et al.   PLoS One

Candida albicans Yeast and Hyphae are Discriminated by MAPK Signaling in Vaginal Epithelial Cells

(2011) David L. Moyes et al.   PLoS One

Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans

(2011) P. S. Salgado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Strengthening relationships: amyloids create adhesion nanodomains in yeasts

(2011) Peter N. Lipke et al.   TRENDS IN MICROBIOLOGY

Sur7 Promotes Plasma Membrane Organization and Is Needed for Resistance to Stressful Conditions and to the Invasive Growth and Virulence of Candida albicans

(2011) L. M. Douglas et al.   mBio

Mechanisms of Candida albicans Trafficking to the Brain

(2011) Yaoping Liu et al.   PLoS Pathogens

Candida albicans SUR7 contributes to secretion, biofilm formation, and macrophage killing

(2010) Stella M Bernardo et al.   BMC MICROBIOLOGY

A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

(2010) David L. Moyes et al.   Cell Host & Microbe

The Candida albicans Sur7 Protein Is Needed for Proper Synthesis of the Fibrillar Component of the Cell Wall That Confers Strength

(2010) Hong X. Wang et al.   EUKARYOTIC CELL

Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis

(2010) J. Yano et al.   INFECTION AND IMMUNITY

Epithelial Cells and Innate Antifungal Defense

(2010) G. Weindl et al.   JOURNAL OF DENTAL RESEARCH

Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans

(2010) Woong Sik Jang et al.   MOLECULAR MICROBIOLOGY

Effects of smoking on trace metal levels in saliva

(2010) Y-J Kim et al.   ORAL DISEASES

Force-induced formation and propagation of adhesion nanodomains in living fungal cells

(2010) D. Alsteens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometric analysis of the secretome of Candida albicans

(2010) Alice G. Sorgo et al.   YEAST

Candida albicansinternalization by host cells is mediated by a clathrin-dependent mechanism

(2009) Emilia Moreno-Ruiz et al.   CELLULAR MICROBIOLOGY

Cellular interactions ofCandida albicanswith human oral epithelial cells and enterocytes

(2009) Frederic Dalle et al.   CELLULAR MICROBIOLOGY

Pattern recognition: recent insights from Dectin-1

(2009) Delyth M Reid et al.   CURRENT OPINION IN IMMUNOLOGY

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections

(2009) Bart Ferwerda et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide

(2009) Timothy F. Meiller et al.   PLoS One

Biofilm Matrix Regulation by Candida albicans Zap1

(2009) Clarissa J. Nobile et al.   PLOS BIOLOGY

Inhibition ofCandida albicansadhesion by recombinant human antibody single-chain variable fragment specific for Als3p

(2008) Sonia S. Laforce-Nesbitt et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Association of small Rho GTPases and actin ring formation in epithelial cells during the invasion byCandida albicans

(2008) Ashwini N. Atre et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Discovering the secrets of theCandida albicansagglutinin-like sequence (ALS) gene family – a sticky pursuit

(2008) Lois L. Hoyer et al.   MEDICAL MYCOLOGY

Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis

(2008) Julian R. Naglik et al.   MICROBIOLOGY-SGM

Secreted aspartic proteases are not required for invasion of reconstituted human epithelia by Candida albicans

(2008) Ulrich Lermann et al.   MICROBIOLOGY-SGM

The Sur7 Protein Regulates Plasma Membrane Organization and Prevents Intracellular Cell Wall Growth in Candida albicans

(2008) Francisco J. Alvarez et al.   MOLECULAR BIOLOGY OF THE CELL

An endocytic mechanism for haemoglobin-iron acquisition inCandida albicans

(2008) Ziva Weissman et al.   MOLECULAR MICROBIOLOGY

The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin

(2008) Ricardo S. Almeida et al.   PLoS Pathogens