Epstein–Barr Virus and Innate Immunity: Friends or Foes?

Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation

(2019) Yan Chen et al.   PLoS Pathogens

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication

(2018) Roman Radetskyy et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Epstein-Barr virus-encoded microRNAs as regulators in host immune responses

(2018) Man Wang et al.   International Journal of Biological Sciences

Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

(2018) Tate Tabtieng et al.   JOURNAL OF VIROLOGY

Emerging pro-viral roles of caspases during lytic replication of gammaherpesviruses

(2018) Tate Tabtieng et al.   JOURNAL OF VIROLOGY

Enhancer control of miR-155 expression in Epstein-Barr virus infected B cells

(2018) C. David Wood et al.   JOURNAL OF VIROLOGY

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

(2018) Xiaolan Liu et al.   Cell Death & Disease

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome

(2018) Soham Gupta et al.   PLoS Pathogens

Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction

(2018) Dong-Wen Lv et al.   PLoS Pathogens

Beta and Gamma Human Herpesviruses: Agonistic and Antagonistic Interactions with the Host Immune System

(2018) Mario E. Cruz-Muñoz et al.   Frontiers in Microbiology

Latent Membrane Protein 1 of Epstein–Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway

(2018) Chongfeng Xu et al.   Frontiers in Immunology

TRIM29 negatively controls antiviral immune response through targeting STING for degradation

(2018) Qijie Li et al.   Cell Discovery

Necroptosis in anti-viral inflammation

(2018) Himani Nailwal et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

(2018) Pei‐Hui Wang et al.   EMBO REPORTS

Poxviral protein E3–altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor–stimulated immune responses

(2018) Alan Dempsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection

(2018) Yee Ching Ng et al.   NUCLEIC ACIDS RESEARCH

Contribution of the KSHV and EBV lytic cycles to tumourigenesis

(2018) Oliver Manners et al.   Current Opinion in Virology

EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation

(2018) M.S. Gilardini Montani et al.   Autophagy

Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection

(2018) Kendra A. Bussey et al.   JOURNAL OF VIROLOGY

Cellular RNA helicase DHX9 interacts with the essential EBV protein SM and restricts EBV lytic replication.

(2018) Wenmin Fu et al.   JOURNAL OF VIROLOGY

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EBV MicroRNA BART16 Suppresses Type I IFN Signaling

(2017) Marjolein J. G. Hooykaas et al.   JOURNAL OF IMMUNOLOGY

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway

(2017) Yuanjun Lu et al.   Journal of Innate Immunity

Epstein-Barr Virus LMP1-Mediated Oncogenicity

(2017) Liang Wei Wang et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G

(2017) Fabrice Mure et al.   JOURNAL OF VIROLOGY

MicroRNAs of Epstein-Barr Virus Control Innate and Adaptive Antiviral Immunity

(2017) Manuel Albanese et al.   JOURNAL OF VIROLOGY

An Epstein-Barr Virus MicroRNA Blocks Interleukin-1 (IL-1) Signaling by Targeting IL-1 Receptor 1

(2017) Camille M. Skinner et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription via the mTORC1/NF-κB Signaling Pathways

(2017) Jun Zhang et al.   JOURNAL OF VIROLOGY

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure

(2017) Anna M. Gram et al.   MOLECULAR IMMUNOLOGY

Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3

(2017) Ryan Incrocci et al.   VIROLOGY

Interferon-γ-inducible protein 16 (IFI16) is required for the maintenance of Epstein-Barr virus latency

(2017) Gina Pisano et al.   Virology Journal

TRIM29 promotes DNA virus infections by inhibiting innate immune response

(2017) Junji Xing et al.   Nature Communications

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation

(2017) Kun Zhang et al.   Cell Reports

LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

(2017) Ting-Ting Cai et al.   PLoS Pathogens

Epstein-Barr virus infection-induced inflammasome activation in human monocytes

(2017) Yuka Torii et al.   PLoS One

Beyond the grave: When is cell death critical for immunity to infection?

(2016) HN Stephenson et al.   CURRENT OPINION IN IMMUNOLOGY

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses

(2016) Wenwei Li et al.   JOURNAL OF VIROLOGY

Nuclear Innate Immune DNA Sensor IFI16 Is Degraded during Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV): Role of IFI16 in Maintenance of KSHV Latency

(2016) Arunava Roy et al.   JOURNAL OF VIROLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Sensing of latent EBV infection through exosomal transfer of 5′pppRNA

(2016) S. Rubina Baglio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein-Barr viral microRNAs target caspase 3

(2016) Cecelia Harold et al.   Virology Journal

Ablation of STAT3 in the B Cell Compartment Restricts Gammaherpesvirus Latency In Vivo

(2016) Sandeep Steven Reddy et al.   mBio

Epstein–Barr Virus: Diseases Linked to Infection and Transformation

(2016) Hem C. Jha et al.   Frontiers in Microbiology

Epstein-Barr Virus: The Path from Latent to Productive Infection

(2016) Ya-Fang Chiu et al.   Annual Review of Virology

Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection

(2015) Isa Muñoz-Arias et al.   Cell Host & Microbe

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China

(2015) Fang Ye et al.   FASEB JOURNAL

Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells

(2015) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by InhibitingBAD-Mediatedcaspase-3-Dependent Apoptosis

(2015) Hyoji Kim et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus BZLF1-Mediated Downregulation of Proinflammatory Factors Is Essential for Optimal Lytic Viral Replication

(2015) Yuqing Li et al.   JOURNAL OF VIROLOGY

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockout of Epstein-Barr Virus BPLF1 Retards B-Cell Transformation and Lymphoma Formation in Humanized Mice

(2015) Christopher B. Whitehurst et al.   mBio

Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses

(2015) Mairaj Ahmed Ansari et al.   PLoS Pathogens

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival

(2015) Dong Kang et al.   PLoS Pathogens

EBV-Encoded miR-BART20-5p and miR-BART8 Inhibit the IFN-γ–STAT1 Pathway Associated with Disease Progression in Nasal NK-Cell Lymphoma

(2014) Wei-Ting Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Silencing the shutoff protein of Epstein-Barr virus in productively infected B cells points to (innate) targets for immune evasion

(2014) M. van Gent et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection

(2014) Nicolas Zucchini et al.   JOURNAL OF IMMUNOLOGY

The EBV-Encoded dUTPase Activates NF- B through the TLR2 and MyD88-Dependent Signaling Pathway

(2014) M.-E. Ariza et al.   JOURNAL OF IMMUNOLOGY

Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88

(2014) Qinglan Zhao et al.   JOURNAL OF VIROLOGY

Comprehensive High-Throughput RNA Sequencing Analysis Reveals Contamination of Multiple Nasopharyngeal Carcinoma Cell Lines with HeLa Cell Genomes

(2014) M. J. Strong et al.   JOURNAL OF VIROLOGY

Repression of interferon regulatory factor 3 by the Epstein-Barr virus immediate-early protein Rta is mediated through E2F1 in HeLa cells

(2014) LIANG-HUA ZHU et al.   Molecular Medicine Reports

Regulation of the latent-lytic switch in Epstein–Barr virus

(2014) Shannon C. Kenney et al.   SEMINARS IN CANCER BIOLOGY

Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling

(2014) Michiel van Gent et al.   PLoS Pathogens

IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications

(2014) Karen E. Johnson et al.   PLoS Pathogens

The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma

(2014) Maria Ambrosio et al.   Infectious Agents and Cancer

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

(2013) M. A. Ansari et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Deubiquitinase Downregulates TRAF6-Mediated NF- B Signaling during Productive Replication

(2013) S. Saito et al.   JOURNAL OF VIROLOGY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Epstein–Barr virus maintains lymphomas via its miRNAs

(2013) D T Vereide et al.   ONCOGENE

NF-κB-mediated transcriptional upregulation of TNFAIP2 by the Epstein–Barr virus oncoprotein, LMP1, promotes cell motility in nasopharyngeal carcinoma

(2013) C-C Chen et al.   ONCOGENE

Switching of EBV cycles between latent and lytic states

(2013) Takayuki Murata et al.   REVIEWS IN MEDICAL VIROLOGY

The EBV Latent Antigen 3C Inhibits Apoptosis through Targeted Regulation of Interferon Regulatory Factors 4 and 8

(2013) Shuvomoy Banerjee et al.   PLoS Pathogens

Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells

(2013) Stefano Gastaldello et al.   PLoS Pathogens

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma

(2012) Lih-Chyang Chen et al.   EMBO Molecular Medicine

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Inflammasomes and viruses: cellular defence versus viral offence

(2012) A. M. Gram et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Epstein-Barr Virus BGLF4 Kinase Downregulates NF- B Transactivation through Phosphorylation of Coactivator UXT

(2012) L.-S. Chang et al.   JOURNAL OF VIROLOGY

The Latent Membrane Protein 1 (LMP1) Oncogene of Epstein-Barr Virus Can Simultaneously Induce and Inhibit Apoptosis in B Cells

(2012) Zachary L. Pratt et al.   JOURNAL OF VIROLOGY

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Roles of the Kinase TAK1 in TRAF6-Dependent Signaling by CD40 and Its Oncogenic Viral Mimic, LMP1

(2012) Kelly M. Arcipowski et al.   PLoS One

Toll-Like Receptor 7 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1

(2012) Robert M. Valente et al.   PLoS One

E2F1 Mediated Apoptosis Induced by the DNA Damage Response Is Blocked by EBV Nuclear Antigen 3C in Lymphoblastoid Cells

(2012) Abhik Saha et al.   PLoS Pathogens

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Molecular Mechanisms of TNFR-associated Factor 6 (TRAF6) Utilization by the Oncogenic Viral Mimic of CD40, Latent Membrane Protein 1 (LMP1)

(2011) Kelly M. Arcipowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaposi Sarcoma-associated Herpesvirus Degrades Cellular Toll-Interleukin-1 Receptor Domain-containing Adaptor-inducing β-Interferon (TRIF)

(2011) Humera Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Murine Gammaherpesvirus 68 Evades Host Cytokine Production via Replication Transactivator-Induced RelA Degradation

(2011) X. Dong et al.   JOURNAL OF VIROLOGY

The Epstein–Barr Virus BART microRNAs target the pro-apoptotic protein Bim

(2011) Aron R. Marquitz et al.   VIROLOGY

Systematic Analysis of Viral and Cellular MicroRNA Targets in Cells Latently Infected with Human γ-Herpesviruses by RISC Immunoprecipitation Assay

(2010) Lars Dölken et al.   Cell Host & Microbe

TLR9 Contributes to the Recognition of EBV by Primary Monocytes and Plasmacytoid Dendritic Cells

(2010) S. Fiola et al.   JOURNAL OF IMMUNOLOGY

EBV Latent Membrane Protein 1 Is a Negative Regulator of TLR9

(2010) I. Fathallah et al.   JOURNAL OF IMMUNOLOGY

EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive Infection

(2010) M. van Gent et al.   JOURNAL OF IMMUNOLOGY

EBNA3C Attenuates the Function of p53 through Interaction with Inhibitor of Growth Family Proteins 4 and 5

(2010) A. Saha et al.   JOURNAL OF VIROLOGY

Epstein Barr virus inhibits the stimulatory effect of TLR7/8 and TLR9 agonists but not CD40 ligand in human B lymphocytes

(2010) Vahid Younesi et al.   MICROBIOLOGY AND IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

TLR9 triggering in Burkitt's lymphoma cell lines suppresses the EBV BZLF1 transcription via histone modification

(2010) L Zauner et al.   ONCOGENE

Dual Functions of Interferon Regulatory Factors 7C in Epstein-Barr Virus–Mediated Transformation of Human B Lymphocytes

(2010) Yong Zhao et al.   PLoS One

Epstein-Barr Virus Interferes with the Amplification of IFNα Secretion by Activating Suppressor of Cytokine Signaling 3 in Primary Human Monocytes

(2010) François Michaud et al.   PLoS One

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein–Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-β

(2010) Gretchen L. Bentz et al.   VIROLOGY

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

(2010) Marc Kvansakul et al.   PLoS Pathogens

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication

(2010) Xiaonan Dong et al.   PLoS Pathogens

Upregulation of interleukin-1 by Epstein-Barr virus latent membrane protein 1 and its possible role in nasopharyngeal carcinoma cell growth

(2009) Yu-Tzu Huang et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Epstein-Barr virus (EBV)–encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3

(2009) Dai Iwakiri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

(2009) K M Shah et al.   ONCOGENE

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

(2009) A. L. Desbien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

(2009) Gemma L. Kelly et al.   PLoS Pathogens

EBV MicroRNAs in Primary Lymphomas and Targeting of CXCL-11 by ebv-mir-BHRF1-3

(2008) T. Xia et al.   CANCER RESEARCH

Authentication of nasopharyngeal carcinoma tumor lines

(2008) Sylvia Yat-Yee Chan et al.   INTERNATIONAL JOURNAL OF CANCER

An Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival

(2008) Elizabeth Yee-Wai Choy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epstein-Barr Virus LF2: an Antagonist to Type I Interferon

(2008) L. Wu et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus-Induced miR-155 Attenuates NF- B Signaling and Stabilizes Latent Virus Persistence

(2008) F. Lu et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway

(2008) J.-T. Wang et al.   JOURNAL OF VIROLOGY

Upregulation of the TLR3 Pathway by Kaposi's Sarcoma-Associated Herpesvirus during Primary Infection

(2008) J. West et al.   JOURNAL OF VIROLOGY

MicroRNA-155 Is an Epstein-Barr Virus-Induced Gene That Modulates Epstein-Barr Virus-Regulated Gene Expression Pathways

(2008) Q. Yin et al.   JOURNAL OF VIROLOGY