Molecular Characteristics of Uveal Melanoma: Insights from the Cancer Genome Atlas (TCGA) Project

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

(2019) Suvi Annala et al.   Science Signaling

Genetic Analysis of Uveal Melanoma in 658 Patients Using the Cancer Genome Atlas Classification of Uveal Melanoma as A, B, C, and D

(2019) Pornpattana Vichitvejpaisal et al.   OPHTHALMOLOGY

The genetic evolution of metastatic uveal melanoma

(2019) A. Hunter Shain et al.   NATURE GENETICS

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology

(2018) Dahlia E. Perez et al.   Pigment Cell & Melanoma Research

Punctuated evolution of canonical genomic aberrations in uveal melanoma

(2018) Matthew G. Field et al.   Nature Communications

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

The Cancer Genome Atlas Project: An Integrated Molecular View of Uveal Melanoma

(2018) Martine J. Jager et al.   OPHTHALMOLOGY

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

(2018) Michael D. Onken et al.   Science Signaling

“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway

(2018) Emira Bousoik et al.   Frontiers in Oncology

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

(2018) Dominic Lapadula et al.   MOLECULAR CANCER RESEARCH

Immunotherapy With Programmed Cell Death 1 Inhibitors for 5 Patients With Conjunctival Melanoma

(2018) Oded Sagiv et al.   JAMA Ophthalmology

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

(2017) Kristen M. Turner et al.   NATURE

BANCR: a novel oncogenic long non-coding RNA in human cancers

(2017) Yifan Zou et al.   Oncotarget

Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing

(2016) Beryl Royer-Bertrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Uveal melanoma: From diagnosis to treatment and the science in between

(2016) Chandrani Chattopadhyay et al.   CANCER

DNA Methylation in Cancer and Aging

(2016) M. Klutstein et al.   CANCER RESEARCH

JAK-STAT signaling in cancer: From cytokines to non-coding genome

(2016) Jan Pencik et al.   CYTOKINE

Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi

(2016) Inga Möller et al.   MODERN PATHOLOGY

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

(2016) Xiao-Feng Xiong et al.   Nature Chemistry

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

(2016) Amanda R Moore et al.   NATURE GENETICS

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish

(2016) Mai Abdel Mouti et al.   Oncotarget

Epidemiological trends in uveal melanoma

(2015) Michael T Andreoli et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma

(2015) Jingtao Peng et al.   CANCER LETTERS

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Whole-genome copy-number analysis identifies new leads for chromosomal aberrations involved in the oncogenesis and metastastic behavior of uveal melanomas

(2015) Adriana C.H. van Engen-van Grunsven et al.   MELANOMA RESEARCH

American Joint Committee on Cancer Classification of Uveal Melanoma (Anatomic Stage) Predicts Prognosis in 7731 Patients

(2015) Carol L. Shields et al.   OPHTHALMOLOGY

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

(2015) Peter Johansson et al.   Oncotarget

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

(2015) Ashley M. Laughney et al.   Cell Reports

PVT1: A Rising Star among Oncogenic Long Noncoding RNAs

(2015) Teresa Colombo et al.   Biomed Research International

Variable Results for Uveal Melanoma–Specific Gene Expression Profile Prognostic Test in Choroidal Metastasis

(2015) Michael A. Klufas et al.   JAMA Ophthalmology

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Deubiquitination of  -Tubulin by BAP1 Prevents Chromosome Instability in Breast Cancer Cells

(2014) R. Zarrizi et al.   CANCER RESEARCH

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations

(2013) X Chen et al.   ONCOGENE

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Chromosomal instability and cancer: a complex relationship with therapeutic potential

(2012) Samuel F. Bakhoum et al.   JOURNAL OF CLINICAL INVESTIGATION

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

Genotypic Profiling of 452 Choroidal Melanomas with Multiplex Ligation-Dependent Probe Amplification

(2010) B. Damato et al.   CLINICAL CANCER RESEARCH

An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal Melanoma

(2010) Michael D. Onken et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognosis of Uveal Melanoma in 500 Cases Using Genetic Testing of Fine-Needle Aspiration Biopsy Specimens

(2010) Carol L. Shields et al.   OPHTHALMOLOGY

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

FISH analysis of chromosomes 3 and 6 on fine needle aspiration biopsy samples identifies distinct subgroups of uveal melanomas

(2008) Laura Bonaldi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE