IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus–cytokine–trypsin cycle

miR-135b, a key regulator of malignancy, is linked to poor prognosis in human myxoid liposarcoma

(2016) Y Nezu et al.   ONCOGENE

Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection

(2015) Lindsay Hill-Batorski et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of interleukin-1 beta (IL-1β) is a critical component of lung inflammation during influenza A (H1N1) virus infection

(2015) Kwang Seok Kim et al.   JOURNAL OF MEDICAL VIROLOGY

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

(2015) Xiaodi Chen et al.   NEUROBIOLOGY OF DISEASE

Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options

(2015) Hiroshi KIDO   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

(2015) Chizuru Yabumoto et al.   Scientific Reports

Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza

(2014) Kazuhiko Yamane et al.   PLoS One

Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation

(2014) Anke Sichelstiel et al.   PLoS One

A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model

(2012) Jing Shan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease

(2012) Byung S Kim et al.   Journal of Neuroinflammation

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

(2011) Hiroshi Kido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Key role of regulated upon activation normal T-cell expressed and secreted, nonstructural protein1 and myeloperoxidase in cytokine storm induced by influenza virus PR-8 (A/H1N1) infection in A549 bronchial epithelial cells

(2011) Thuy Thi Bich Phung et al.   MICROBIOLOGY AND IMMUNOLOGY

IL-1β induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells

(2010) Ching-Yi Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis

(2010) Hai-Yan Pan et al.   CARDIOVASCULAR RESEARCH

Influenza Virus–Cytokine‐Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza

(2010) Siye Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Type II Transmembrane Serine Proteases, MSPL and TMPRSS13, Proteolytically Activate Membrane Fusion Activity of the Hemagglutinin of Highly Pathogenic Avian Influenza Viruses and Induce Their Multicycle Replication

(2010) Y. Okumura et al.   JOURNAL OF VIROLOGY

IL-1β promotes A549 cell migration via MAPKs/AP-1- and NF-κB-dependent matrix metalloproteinase-9 expression

(2009) Chih-Chung Lin et al.   CELLULAR SIGNALLING

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

(2009) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

IL-1β Augments TNF-α–Mediated Inflammatory Responses from Lung Epithelial Cells

(2009) Sara Saperstein et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico

(2009) Rogelio Perez-Padilla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin (IL)-6 and IL-1β act synergistically within the brain to induce sickness behavior and fever in rats

(2008) Lois M. Harden et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin (IL) 1β Induction of IL-6 Is Mediated by a Novel Phosphatidylinositol 3-Kinase-dependent AKT/IκB Kinase α Pathway Targeting Activator Protein-1

(2008) Catherine M. Cahill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypsin is the culprit of multiple organ injury with severe acute pancreatitis

(2008) Huanchen Sha et al.   MEDICAL HYPOTHESES

INDUCTION OF INFLAMMATORY CYTOKINE RELEASE FROM HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS BY AGONISTS OF PROTEINASE-ACTIVATED RECEPTOR-2

(2007) Qing-Xia Niu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY