New psychoactive substances: an overview on recent publications on their toxicodynamics and toxicokinetics

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22

(2016) Xingxing Diao et al.   AAPS Journal

Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes

(2016) Markus R. Meyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Methoxetamine, a novel psychoactive substance with serious adverse pharmacological effects

(2016) Mary T. Zanda et al.   BEHAVIOURAL PHARMACOLOGY

Synthetic Cannabinoids—Further Evidence Supporting the Relationship Between Cannabinoids and Psychosis

(2016) Liana Fattore   BIOLOGICAL PSYCHIATRY

Neurobiology of 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)

(2016) Richard A. Glennon et al.   BRAIN RESEARCH BULLETIN

Intoxications involving the fentanyl analogs acetylfentanyl, 4-methoxybutyrfentanyl and furanylfentanyl: results from the Swedish STRIDA project

(2016) Anders Helander et al.   CLINICAL TOXICOLOGY

Cannabinoids and Cytochrome P450 Interactions

(2016) Ondřej Zendulka et al.   CURRENT DRUG METABOLISM

In vitrometabolism of the synthetic cannabinoid 3,5-AB-CHMFUPPYCA and its 5,3-regioisomer and investigation of their thermal stability

(2016) Florian Franz et al.   Drug Testing and Analysis

Toxicokinetics of new psychoactive substances: plasma protein binding, metabolic stability, and human phase I metabolism of the synthetic cannabinoid WIN 55,212-2 studied usingin vitrotools and LC-HR-MS/MS

(2016) Marie Mardal et al.   Drug Testing and Analysis

Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MSn, and LC-HR-MSn

(2016) Carina S. D. Wink et al.   Drug Testing and Analysis

A fatal intoxication related to MDPV and pentedrone combined with antipsychotic and antidepressant substances in Cyprus

(2016) Katerina Liveri et al.   FORENSIC SCIENCE INTERNATIONAL

Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans

(2016) Shimpei Watanabe et al.   FORENSIC SCIENCE INTERNATIONAL

Seven fatalities associated with ethylphenidate

(2016) P.D. Maskell et al.   FORENSIC SCIENCE INTERNATIONAL

3-Methylmethcathinone—Interpretation of Blood Concentrations Based on Analysis of 95 Cases

(2016) Piotr Adamowicz et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Identification of in vitro metabolites of ethylphenidate by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

(2016) Noelia Negreira et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

In vitro metabolism of a novel synthetic cannabinoid, EAM-2201, in human liver microsomes and human recombinant cytochrome P450s

(2016) Ju Hyun Kim et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification and quantification of metabolites of AB-CHMINACA in a urine specimen of an abuser

(2016) Amin Wurita et al.   Legal Medicine

The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue

(2016) Julie A. Marusich et al.   NEUROPHARMACOLOGY

The potential utility of some legal highs in CNS disorders

(2016) Colin Davidson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Toxicology of New Psychoactive Substances

(2016) Elli Tyrkkö et al.   THERAPEUTIC DRUG MONITORING

New Psychoactive Substances

(2016) Jessica Welter-Luedeke et al.   THERAPEUTIC DRUG MONITORING

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class

(2016) Julia Dinger et al.   TOXICOLOGY LETTERS

Synthetic cannabinoids: In silico prediction of the cannabinoid receptor 1 affinity by a quantitative structure-activity relationship model

(2016) Alexander Paulke et al.   TOXICOLOGY LETTERS

Pharmacokinetics of (synthetic) cannabinoids in pigs and their relevance for clinical and forensic toxicology

(2016) Nadine Schaefer et al.   TOXICOLOGY LETTERS

In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant

(2016) Madeleine J Swortwood et al.   Bioanalysis

Use of novel psychoactive substances by inpatients on general adult psychiatric wards

(2016) Jack L Stanley et al.   BMJ Open

Identification and quantification of metabolites of AB-CHMINACA in a urine specimen of an abuser

(2016) Amin Wurita et al.   Legal Medicine

Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report

(2016) Graham McIlroy et al.   BMC Pharmacology & Toxicology

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA

(2015) Ariane Wohlfarth et al.   AAPS Journal

CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48

(2015) Niels Bjerre Holm et al.   AAPS Journal

Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135

(2015) Samuel D. Banister et al.   ACS Chemical Neuroscience

A Fatal Case of Isolated Methiopropamine (1-(Thiophen-2-yl)-2-Methylaminopropane) Toxicity

(2015) Sravan Anne et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Analytical strategy to investigate 3,4-methylenedioxypyrovalerone (MDPV) metabolites in consumers’ urine by high-resolution mass spectrometry

(2015) María Ibáñez et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MSn techniques

(2015) Jessica Welter et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro Phase I and Phase II metabolism of α-pyrrolidinovalerophenone (α-PVP), methylenedioxypyrovalerone (MDPV) and methedrone by human liver microsomes and human liver cytosol

(2015) Noelia Negreira et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC–MS, LC–MS n , and LC–HR–MS–MS

(2015) Julian A. Michely et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MSn, and LC-HR-MS/MS

(2015) Achim T. Caspar et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Simultaneous LC-MS/MS determination of JWH-210, RCS-4, ∆9-tetrahydrocannabinol, and their main metabolites in pig and human serum, whole blood, and urine for comparing pharmacokinetic data

(2015) Nadine Schaefer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Determination of urinary metabolites of XLR-11 by liquid chromatography–quadrupole time-of-flight mass spectrometry

(2015) Moonhee Jang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Unintentional Pediatric Exposure to a Synthetic Cannabinoid (AB-PINACA) Resulting in Coma and Intubation

(2015) Stephen L. Thornton et al.   ANNALS OF EMERGENCY MEDICINE

Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage

(2015) Andrea Bileck et al.   ARCHIVES OF TOXICOLOGY

4,4′-DMAR: Chemistry, Pharmacology and Toxicology of a New Synthetic Stimulant of Abuse

(2015) Maurizio Coppola et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

P-glycoprotein interactions of novel psychoactive substances – Stimulation of ATP consumption and transport across Caco-2 monolayers

(2015) Markus R. Meyer et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacological profile of novel psychoactive benzofurans

(2015) Anna Rickli et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes

(2015) X. Diao et al.   CLINICAL CHEMISTRY

Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018

(2015) MK Su et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phencyclidine analog use in Sweden—intoxication cases involving 3-MeO-PCP and 4-MeO-PCP from the STRIDA project

(2015) Matilda Bäckberg et al.   CLINICAL TOXICOLOGY

An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA

(2015) Joseph A. Tyndall et al.   CLINICAL TOXICOLOGY

Prevalence of use and acute toxicity associated with the use of NBOMe drugs

(2015) David M. Wood et al.   CLINICAL TOXICOLOGY

Intoxications involving MDPV in Sweden during 2010–2014: Results from the STRIDA project

(2015) Olof Beck et al.   CLINICAL TOXICOLOGY

Opioid intoxications involving butyrfentanyl, 4-fluorobutyrfentanyl, and fentanyl from the Swedish STRIDA project

(2015) Matilda Bäckberg et al.   CLINICAL TOXICOLOGY

Flubromazolam – A new life-threatening designer benzodiazepine

(2015) Magdalena Łukasik-Głębocka et al.   CLINICAL TOXICOLOGY

Intoxications by the dissociative new psychoactive substances diphenidine and methoxphenidine

(2015) Anders Helander et al.   CLINICAL TOXICOLOGY

Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN)

(2015) Alison M Dines et al.   CLINICAL TOXICOLOGY

Recreational Use, Analysis and Toxicity of Tryptamines

(2015) Roberta Tittarelli et al.   Current Neuropharmacology

Next generation of novel psychoactive substances on the horizon – A complex problem to face

(2015) Jolanta B. Zawilska et al.   DRUG AND ALCOHOL DEPENDENCE

Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans

(2015) Johanna J. Nugteren-van Lonkhuyzen et al.   DRUG AND ALCOHOL DEPENDENCE

Synthetic cannabinoids pharmacokinetics and detection methods in biological matrices

(2015) Marisol S. Castaneto et al.   DRUG METABOLISM REVIEWS

In vitrocharacterization of potential CYP- and UGT-derived metabolites of the psychoactive drug 25B-NBOMe using LC-high resolution MS

(2015) Yacine Boumrah et al.   Drug Testing and Analysis

Detection of main metabolites of XLR-11 and its thermal degradation product in human hepatoma HepaRG cells and human urine

(2015) Tatsuyuki Kanamori et al.   Drug Testing and Analysis

In vitroandin vivohuman metabolism of the synthetic cannabinoid AB-CHMINACA

(2015) Claudio Erratico et al.   Drug Testing and Analysis

Ethylphenidate: availability, patterns of use, and acute effects of this novel psychoactive substance

(2015) James H. Ho et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Monoamine transporter and receptor interaction profiles of novel psychoactive substances: Para-halogenated amphetamines and pyrovalerone cathinones

(2015) Anna Rickli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

In vivo detection of the new psychoactive substance AM-694 and its metabolites

(2015) Elisabetta Bertol et al.   FORENSIC SCIENCE INTERNATIONAL

Concentrations of APINACA, 5F-APINACA, UR-144 and its degradant product in blood samples from six impaired drivers compared to previous reported concentrations of other synthetic cannabinoids

(2015) Ritva Karinen et al.   FORENSIC SCIENCE INTERNATIONAL

A review of ethylphenidate in deaths in east and west Scotland

(2015) Claire Parks et al.   FORENSIC SCIENCE INTERNATIONAL

AH-7921: the list of new psychoactive opioids is expanded

(2015) Maria Katselou et al.   Forensic Toxicology

4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

(2015) Kayla N. Ellefsen et al.   Forensic Toxicology

4-Methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine (4,4′-DMAR, 4,4′-dimethylaminorex): availability, prevalence of use, desired effects and acute toxicity

(2015) James Glanville et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

The pharmacology and toxicology of kratom: from traditional herb to drug of abuse

(2015) Marcus L. Warner et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS

(2015) Kei Zaitsu et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Identification of AKB-48 and 5F-AKB-48 Metabolites in Authentic Human Urine Samples Using Human Liver Microsomes and Time of Flight Mass Spectrometry

(2015) Svante Vikingsson et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Effects of Cannabinoids on T-cell Function and Resistance to Infection

(2015) Toby K. Eisenstein et al.   Journal of Neuroimmune Pharmacology

Liquid chromatography-quadrupole time-of-flight mass spectrometry for screening in vitro drug metabolites in humans: investigation on seven phenethylamine-based designer drugs

(2015) Foon Yin Lai et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects

(2015) Jan van Amsterdam et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Unusually Prolonged Presentation of Designer Drug Encephalopathy Responsive to Steroids

(2015) R. Albadareen et al.   PEDIATRICS

Butyrfentanyl Overdose Resulting in Diffuse Alveolar Hemorrhage

(2015) J. B. Cole et al.   PEDIATRICS

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

(2015) Reem Smoum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Synthetic Cannabinoid UR-144 on Human Psychomotor Performance—A Case Report Demonstrating Road Traffic Risks

(2015) Piotr Adamowicz et al.   Traffic Injury Prevention

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

(2015) Harald H. Sitte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Designer benzodiazepines: A new challenge

(2015) Bjoern Moosmann et al.   World Psychiatry

Novel psychoactive substances of interest for psychiatry

(2015) Fabrizio Schifano et al.   World Psychiatry

Following “the Roots” of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries

(2015) Eduardo Cinosi et al.   Biomed Research International

Analysis of New Designer Drugs in Post-Mortem Blood Using High-Resolution Mass Spectrometry

(2015) D. Pasin et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

WIN 55,212-2, Agonist of Cannabinoid Receptors, Prevents Amyloid β1-42 Effects on Astrocytes in Primary Culture

(2015) Diana Aguirre-Rueda et al.   PLoS One

Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MSn techniques

(2014) Jessica Welter et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach

(2014) Julia Dinger et al.   ARCHIVES OF TOXICOLOGY

Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of ‘legal high’ packages containing synthetic cathinones

(2014) Ana Margarida Araújo et al.   ARCHIVES OF TOXICOLOGY

Understanding the availability, prevalence of use, desired effects, acute toxicity and dependence potential of the novel opioid MT-45

(2014) Sindhu Siddiqi et al.   CLINICAL TOXICOLOGY

Characteristics of analytically confirmed 3-MMC-related intoxications from the Swedish STRIDA project

(2014) Matilda Bäckberg et al.   CLINICAL TOXICOLOGY

High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135), using cryopreserved human hepatocytes and assessment of metabolic stability with human liv

(2014) Adarsh S. Gandhi et al.   Drug Testing and Analysis

Synthetic cannabimimetic agents metabolized by carboxylesterases

(2014) Ragnar Thomsen et al.   Drug Testing and Analysis

Elucidation of the metabolites of the novel psychoactive substance 4-methyl-N-ethyl-cathinone (4-MEC) in human urine and pooled liver microsomes by GC-MS and LC-HR-MS/MS techniques and of its detectability by GC-MS or LC-MSnstandard screening approaches

(2014) Andreas G. Helfer et al.   Drug Testing and Analysis

Study on the phase I metabolism of novel synthetic cannabinoids, APICA and its fluorinated analogue

(2014) Tim Sobolevsky et al.   Drug Testing and Analysis

Metabolites of 5F-AKB-48, a synthetic cannabinoid receptor agonist, identified in human urine and liver microsomal preparations using liquid chromatography high-resolution mass spectrometry

(2014) Niels Bjerre Holm et al.   Drug Testing and Analysis

Synthesis, characterization, and monoamine transporter activity of the new psychoactive substance 3′,4′-methylenedioxy-4-methylaminorex (MDMAR)

(2014) Gavin McLaughlin et al.   Drug Testing and Analysis

Detection of new psychoactive substance use among emergency room patients: Results from the Swedish STRIDA project

(2014) Anders Helander et al.   FORENSIC SCIENCE INTERNATIONAL

Delayed seizure-like activity following analytically confirmed use of previously unreported synthetic cannabinoid analogues

(2014) LJ Schep et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane

(2014) Andreas Anderluh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5-(2-Aminopropyl)indole (5-IT): a psychoactive substance used for recreational purposes is an inhibitor of human monoamine oxidase (MAO)

(2013) Tomás Herraiz et al.   Drug Testing and Analysis

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

(2013) Bryan L. Roth et al.   PLoS One

Identification of novel psychoactive drug use in Sweden based on laboratory analysis – initial experiences from the STRIDA project

(2013) Anders Helander et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

A Closer Look at Amphetamine-Induced Reverse Transport and Trafficking of the Dopamine and Norepinephrine Transporters

(2009) S. D. Robertson et al.   MOLECULAR NEUROBIOLOGY