Toxicology of organophosphorus compounds in view of an increasing terrorist threat

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

(2016) Sophie Letort et al.   Beilstein Journal of Organic Chemistry

Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig

(2016) Matthew E. Price et al.   TOXICOLOGY LETTERS

Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds

(2016) Anne Bierwisch et al.   TOXICOLOGY LETTERS

Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro

(2015) Moshe Goldsmith et al.   ARCHIVES OF TOXICOLOGY

Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX

(2015) Courtney M. Daczkowski et al.   BIOCHEMISTRY

Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates

(2015) Francine S. Katz et al.   CHEMBIOCHEM

Estimation of Monocrotophos renal elimination half-life in humans

(2015) Arun Jose et al.   CLINICAL TOXICOLOGY

Discovery of non-oxime reactivators using an in silico pharmacophore model of reactivators for DFP-inhibited acetylcholinesterase

(2015) Apurba K. Bhattacharjee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats

(2015) Trond Myhrer et al.   NEUROTOXICOLOGY

Toxicity and medical countermeasure studies on the organophosphorus nerve agents VM and VX

(2015) H. Rice et al.   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes

(2015) Franz Worek et al.   TOXICOLOGY IN VITRO

In vitro and in vivo toxicological studies of V nerve agents: Molecular and stereoselective aspects

(2015) Georg Reiter et al.   TOXICOLOGY LETTERS

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines

(2015) Avi Ring et al.   PLoS One

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

(2014) Franz Worek et al.   ARCHIVES OF TOXICOLOGY

Suicide in Sri Lanka 1975–2012: age, period and cohort analysis of police and hospital data

(2014) Duleeka W Knipe et al.   BMC PUBLIC HEALTH

Mini review on blood-brain barrier penetration of pyridinium aldoximes

(2014) H. Kalász et al.   JOURNAL OF APPLIED TOXICOLOGY

Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification

(2014) Rakesh K. Sit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning

(2014) Colin J. Jackson et al.   TOXICOLOGY

Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study

(2014) Franz Worek et al.   TOXICOLOGY LETTERS

Biological monitoring for exposure to methamidophos: A human oral dosing study

(2014) F. Garner et al.   TOXICOLOGY LETTERS

Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo

(2014) Franz Worek et al.   TOXICOLOGY LETTERS

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

(2013) Izhack Cherny et al.   ACS Chemical Biology

Progress in the development of enzyme-based nerve agent bioscavengers

(2013) Florian Nachon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The value of novel oximes for treatment of poisoning by organophosphorus compounds

(2013) Franz Worek et al.   PHARMACOLOGY & THERAPEUTICS

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

(2012) Guillaume Mercey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Timing of decontamination and treatment in case of percutaneous VX poisoning: A mini review

(2012) Marloes J.A. Joosen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning

(2012) Helen Mumford et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anticholinesterase insecticide retrospective

(2012) John E. Casida et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Factors associated with the decline in suicide by pesticide poisoning in Taiwan: A time trend analysis, 1987–2010

(2012) Shu-Sen Chang et al.   CLINICAL TOXICOLOGY

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro

(2012) T. Seeger et al.   TOXICOLOGY

A role for solvents in the toxicity of agricultural organophosphorus pesticides

(2012) Michael Eddleston et al.   TOXICOLOGY

Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs

(2011) Helen Mumford et al.   CLINICAL TOXICOLOGY

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

(2011) Rakesh K. Sit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning

(2011) Horst Thiermann et al.   TOXICOLOGY LETTERS

Immobilization of Russian VX skin depots by localized cooling: Implications for decontamination and medical countermeasures

(2011) J. Mikler et al.   TOXICOLOGY LETTERS

Ion Mobility Spectrometry and Its Applications in Detection of Chemical Warfare Agents

(2010) Marko A. Mäkinen et al.   ANALYTICAL CHEMISTRY

Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: Is there a structure–activity relationship?

(2010) Nadine Aurbek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pseudo-catalytic scavenging: Searching for a suitable reactivator of phosphorylated butyrylcholinesterase

(2010) Zrinka Kovarik et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure Reduction Paste Against Chemical Warfare Agents, Part 1: Guinea pigs challenged with VX

(2010) Ernest H. Braue et al.   Cutaneous and Ocular Toxicology

Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration

(2010) O. Tenberken et al.   TOXICOLOGY LETTERS

Design, evaluation and structure-Activity relationship studies of the AChE reactivators against organophosphorus pesticides

(2009) Kamil Musilek et al.   MEDICINAL RESEARCH REVIEWS

Structure, Activities and Biomedical Applications of Human Butyrylcholinesterase

(2009) Patrick Masson et al.   PROTEIN AND PEPTIDE LETTERS

Interaction of pentylsarin analogues with human acetylcholinesterase: A kinetic study

(2009) F. Worek et al.   TOXICOLOGY LETTERS

Pralidoxime in Acute Organophosphorus Insecticide Poisoning—A Randomised Controlled Trial

(2009) Michael Eddleston et al.   PLOS MEDICINE

Comparison of selected skin decontaminant products and regimens against VX in domestic swine

(2008) S Bjarnason et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples

(2008) Georg Reiter et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Therapy against organophosphate poisoning: The importance of anticholinergic drugs with antiglutamatergic properties

(2008) Ben Avi Weissman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A novel approach to assessing percutaneous VX poisoning in the conscious guinea‐pig

(2007) Helen Mumford et al.   JOURNAL OF APPLIED TOXICOLOGY