Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

(2014) Franz Worek et al.   ARCHIVES OF TOXICOLOGY

Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study

(2014) Franz Worek et al.   TOXICOLOGY LETTERS

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

(2013) Izhack Cherny et al.   ACS Chemical Biology

Progress in the development of enzyme-based nerve agent bioscavengers

(2013) Florian Nachon et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Limitations and challenges in treatment of acute chemical warfare agent poisoning

(2013) Horst Thiermann et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

(2013) Andrew N. Bigley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The value of novel oximes for treatment of poisoning by organophosphorus compounds

(2013) Franz Worek et al.   PHARMACOLOGY & THERAPEUTICS

Assessing the utility of coevolution-based residue-residue contact predictions in a sequence- and structure-rich era

(2013) H. Kamisetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin – An in vitro structure–activity study

(2013) Anne Bierwisch et al.   TOXICOLOGY LETTERS

Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification

(2012) Moshe Goldsmith et al.   CHEMISTRY & BIOLOGY

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

(2012) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

(2011) Michael Remmert et al.   NATURE METHODS

Stereoselective Hydrolysis of Organophosphate Nerve Agents by the Bacterial Phosphotriesterase

(2010) Ping-Chuan Tsai et al.   BIOCHEMISTRY

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

(2009) C. J. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, Activities and Biomedical Applications of Human Butyrylcholinesterase

(2009) Patrick Masson et al.   PROTEIN AND PEPTIDE LETTERS

Macromolecular Modeling with Rosetta

(2008) Rhiju Das et al.   Annual Review of Biochemistry

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

(2008) David L. Eaton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples

(2008) Georg Reiter et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Degradation of nerve agents by an organophosphate-degrading agent (OpdA)

(2008) R.M. Dawson et al.   JOURNAL OF HAZARDOUS MATERIALS

Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning

(2008) R. C. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA