Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4

(2016) Jeong Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

(2016) H.-S. Lee et al.   CANCER RESEARCH

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client

(2016) Johannes W. Bigenzahn et al.   MOLECULAR & CELLULAR PROTEOMICS

Practical Approaches to the Management of Dual Refractory Multiple Myeloma

(2016) Hans C. Lee et al.   Current Hematologic Malignancy Reports

Tamibarotene in patients with acute promyelocytic leukaemia relapsing after treatment with all-transretinoic acid and arsenic trioxide

(2015) David Sanford et al.   BRITISH JOURNAL OF HAEMATOLOGY

Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

(2015) Takayo Fukuda et al.   CANCER SCIENCE

NFkB is activated by multiple mechanisms in hairy cell leukemia

(2015) Stefan Nagel et al.   GENES CHROMOSOMES & CANCER

Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation

(2015) Sivareddy Kotla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic acid receptors: From molecular mechanisms to cancer therapy

(2015) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

Acute promyelocytic leukemia: where did we start, where are we now and the future

(2015) C C Coombs et al.   Blood Cancer Journal

A critical role for the NFkB pathway in multiple myeloma

(2015)   Oncotarget

Caspase-3 and Caspase-6 cleave STAT1 in leukemic cells

(2015) Verena Licht et al.   Oncotarget

Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients

(2014) M. Tassara et al.   BLOOD

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells

(2014) D Hennig et al.   BRITISH JOURNAL OF CANCER

Role of cell cycle regulatory molecules in retinoic acid- and vitamin D3-induced differentiation of acute myeloid leukaemia cells

(2014) X. T. Hu et al.   CELL PROLIFERATION

Up-Regulation of P21 Inhibits TRAIL-Mediated Extrinsic Apoptosis, Contributing Resistance to SAHA in Acute Myeloid Leukemia Cells

(2014) Xing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism

(2014) Kwai Fung Hui et al.   INTERNATIONAL JOURNAL OF CANCER

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

(2014) Peter M. Wilson et al.   Nature Reviews Clinical Oncology

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response

(2014) Teodora Nikolova et al.   TOXICOLOGICAL SCIENCES

Drugging the HDAC6–HSP90 interplay in malignant cells

(2014) Oliver H. Krämer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Exposure to a Histone Deacetylase Inhibitor Has Detrimental Effects on Human Lymphocyte Viability and Function

(2014) D. J. L. Wong et al.   Cancer Immunology Research

Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC

(2013) Sridurga Mithraprabhu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response

(2013) Bo Cai et al.   CANCER LETTERS

Enhancement of differentiation induction and upregulation of CCAAT/enhancer-binding proteins and PU.1 in NB4 cells treated with combination of ATRA and valproic acid

(2013) NORIYOSHI IRIYAMA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MEK/ERK Dependent Activation of STAT1 Mediates Dasatinib-Induced Differentiation of Acute Myeloid Leukemia

(2013) Yanfen Fang et al.   PLoS One

Inhibition of Histone Deacetylase 3 Causes Replication Stress in Cutaneous T Cell Lymphoma

(2013) Christina E. Wells et al.   PLoS One

Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents

(2013) Hanne Fredly et al.   Clinical Epigenetics

Acetylation modulates the STAT signaling code

(2012) Martin Wieczorek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Acute promyelocytic leukemia, arsenic, and PML bodies

(2012) Hugues de Thé et al.   JOURNAL OF CELL BIOLOGY

SIAH proteins: critical roles in leukemogenesis

(2012) O H Krämer et al.   LEUKEMIA

Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL

(2012) M Leiva et al.   LEUKEMIA

Bortezomib Sensitizes Human Acute Myeloid Leukemia Cells to All-Trans-Retinoic Acid-Induced Differentiation by Modifying the RAR /STAT1 Axis

(2012) M. Ying et al.   MOLECULAR CANCER THERAPEUTICS

Targeting apoptosis proteins in hematological malignancies

(2011) Nathalie Droin et al.   CANCER LETTERS

The HDAC inhibitor depsipeptide transactivates the p53/p21 pathway by inducing DNA damage

(2011) Haiying Wang et al.   DNA REPAIR

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Differential regulation of PML–RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1

(2011) Kristin Pietschmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

(2011) M. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo

(2010) G. Dasmahapatra et al.   BLOOD

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage

(2010) Chiara Conti et al.   CANCER RESEARCH

Inhibitors of HDACs - Effective Drugs Against Cancer?

(2010) S. Muller et al.   CURRENT CANCER DRUG TARGETS

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia

(2010) A Quintás-Cardama et al.   LEUKEMIA

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In Vivo Deficiency of Both C/EBPβ and C/EBPε Results in Highly Defective Myeloid Differentiation and Lack of Cytokine Response

(2010) Tadayuki Akagi et al.   PLoS One

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Comparison of Clinical Outcomes of Patients with Relapsed Acute Promyelocytic Leukemia Induced with Arsenic Trioxide and Consolidated with Either an Autologous Stem Cell Transplant or an Arsenic Trioxide–Based Regimen

(2009) Rajasekar Thirugnanam et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism

(2009) Sridar V Chittur et al.   BMC GENOMICS

Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells

(2009) William Fazzone et al.   INTERNATIONAL JOURNAL OF CANCER

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage

(2008) A Jiemjit et al.   ONCOGENE

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARα

(2007) Oliver H. Krämer et al.   FASEB JOURNAL