Glycosylation Pattern and in vitro Bioactivity of Reference Follitropin alfa and Biosimilars

Hormonal Regulation of Follicle-Stimulating Hormone Glycosylation in Males

(2019) Stella Campo et al.   Frontiers in Endocrinology

‘Spare’ Luteinizing Hormone Receptors: Facts and Fiction

(2018) Livio Casarini et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers

(2018) K. C. Jonas et al.   Scientific Reports

Estrogen Modulates Specific Life and Death Signals Induced by LH and hCG in Human Primary Granulosa Cells In Vitro

(2017) Livio Casarini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis.

(2017) Rony Seger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneous hCG and hMG commercial preparations result in different intracellular signalling but induce a similar long-term progesterone response in vitro

(2017) Laura Riccetti et al.   MOLECULAR HUMAN REPRODUCTION

Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro

(2017) Laura Riccetti et al.   Reproductive Biology and Endocrinology

In-vivo biological activity and glycosylation analysis of a biosimilar recombinant human follicle-stimulating hormone product (Bemfola) compared with its reference medicinal product (GONAL-f)

(2017) Renato Mastrangeli et al.   PLoS One

Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors

(2017) Laura Riccetti et al.   Scientific Reports

Follicle-stimulating hormone potentiates the steroidogenic activity of chorionic gonadotropin and the anti-apoptotic activity of luteinizing hormone in human granulosa-lutein cells in vitro

(2016) Livio Casarini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis

(2016) Mohammed Akli Ayoub et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Randomized, active-controlled, comparative phase 3 efficacy and safety equivalence trial of Ovaleap® (recombinant human follicle-stimulating hormone) in infertile women using assisted reproduction technology (ART)

(2016) Thomas Strowitzki et al.   Reproductive Biology and Endocrinology

Biosimilar FSH preparations- are they identical twins or just siblings?

(2016) Raoul Orvieto et al.   Reproductive Biology and Endocrinology

The role of kinetic context in apparent biased agonism at GPCRs

(2016) Carmen Klein Herenbrink et al.   Nature Communications

Comparison of pharmacokinetic and safety profiles between Bemfola® and Gonal-f® after subcutaneous application

(2015) Michael Wolzt et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Hypoglycosylated hFSH Has Greater Bioactivity Than Fully Glycosylated Recombinant hFSH in Human Granulosa Cells

(2015) Chao Jiang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A multi-centre phase 3 study comparing efficacy and safety of Bemfola® versus Gonal-f® in women undergoing ovarian stimulation for IVF

(2015) M. Rettenbacher et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Assessing Gonadotropin Receptor Function by Resonance Energy Transfer-Based Assays

(2015) Mohammed Akli Ayoub et al.   Frontiers in Endocrinology

Glycosylation Effects on FSH-FSHR Interaction Dynamics: A Case Study of Different FSH Glycoforms by Molecular Dynamics Simulations

(2015) Biswa Ranjan Meher et al.   PLoS One

Biosimilar recombinant follicle stimulating hormones in infertility treatment

(2014) Daniele Santi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

FSHR polymorphism p.N680S mediates different responses to FSH in vitro

(2014) Livio Casarini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation

(2013) Leif Wide et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

LH and hCG Action on the Same Receptor Results in Quantitatively and Qualitatively Different Intracellular Signalling

(2012) Livio Casarini et al.   PLoS One

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

(2012) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of recombinant human follicle-stimulating hormone (FSH) by mass spectrometric approaches

(2011) Josephine Grass et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells

(2011) Verena Nordhoff et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Mapping the follicle-stimulating hormone-induced signaling networks

(2011) Pauline Gloaguen   Frontiers in Endocrinology

Preferential β-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation☆

(2010) Thibaud Tranchant et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY