Review
Medicine, Research & Experimental
Qiudan Zhang, Chenming Zhong, Shiwei Duan
Summary: LINC00858, a newly discovered long non-coding RNA, shows abnormally high expression in various cancers and can influence tumor cell growth and metastasis by regulating microRNAs. It is also associated with nuclear transcription factors, gene methylation, and the prognosis and clinicopathological characteristics of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Huipeng Nie, Huanliang Liu, Yue Shi, Wenqing Lai, Xuan Liu, Zhuge Xi, Bencheng Lin
Summary: This study found that exposure to different concentrations of oil-mist particulate matter (OMPM) can cause lung injury and fibrosis symptoms. It activates the TGF-beta 1/Smad3 and TGF-beta 1/MAPK p38 signaling pathways by targeting the lung epithelium and fibroblasts, leading to pulmonary fibrosis.
Review
Biochemistry & Molecular Biology
Zoe K. Price, Noor A. Lokman, Masato Yoshihara, Hiroaki Kajiyama, Martin K. Oehler, Carmela Ricciardelli
Summary: Disabled-2 (DAB2) is a key adaptor protein in clathrin mediated endocytosis, regulating signalling pathways involved in homeostasis, cell positioning, and EMT. It functions as a tumour suppressor and negatively regulates key pathways such as MAPK, Wnt, and TGF-β. However, recent studies suggest a complex role of DAB2 in cancer with pro-tumorigenic effects. It is also a common target of microRNAs and has been implicated in promoting metastasis in the tumour microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ghasem Ghasempour, Asghar Mohammadi, Fahimeh Zamani-Garmsiri, Mohammad Najafi
Summary: miR-181b and miR-204 regulate VSMC proliferation and migration through the beta-ARR2/p-ERK1/2 pathway, suggesting a potential therapeutic target for atherosclerosis.
Review
Biochemistry & Molecular Biology
Dandan Peng, Minyang Fu, Manni Wang, Yuquan Wei, Xiawei Wei
Summary: TGF-beta plays essential roles in early embryonic development, organogenesis, immune regulation, tissue repair, and adult homeostasis. Its involvement in fibrosis and cancer is complex and context-dependent, showing both inhibitory and promoting effects. Therapeutics targeting TGF-beta signaling hold promise in treating fibrosis and cancer, although the development is hindered by potential systemic cytotoxicity.
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Article
Oncology
Yanyan Feng, Chuanyu Sun, Lifeng Zhang, Hongyuan Wan, Hangsheng Zhou, Yongquan Chen, Lijie Zhu, Guowei Xia, Yuanyuan Mi
Summary: The coatomer protein complex subunit beta 2 (COPB2) plays an important role in prostate cancer by promoting the proliferation and invasion of cancer cells through the regulation of the MAPK/TGF-beta signaling pathway. COPB2 could potentially serve as a new biomarker for diagnosis and monitoring of prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Cell Biology
Shengkui Qiu, Bowen Li, Yiwen Xia, Zhe Xuan, Zheng Li, Li Xie, Chao Gu, Jialun Lv, Chen Lu, Tianlu Jiang, Lang Fang, Penghui Xu, Jing Yang, Ying Li, Zetian Chen, Lu Zhang, Linjun Wang, Diancai Zhang, Hao Xu, Weizhi Wang, Zekuan Xu
Summary: This study identified circTHBS1 as an oncogenic circRNA that enhances the malignancy of gastric cancer by elevating the expression of INHBA. It provides new insights and a feasible target for the diagnosis and treatment of gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Caitlin O. Caperton, Lee Ann Jolly, Nicole Massoll, Andrew J. Bauer, Aime T. Franco
Summary: Advancements in thyroid cancer research rely on access to experimental models for laboratory investigation. The development and characterization of three novel follicular thyroid cancer (FTC) cell lines from relevant animal models have been demonstrated. These cell lines exhibit potential for in vitro applications and transplantation into immunocompetent hosts, providing insights into the heterogeneity of pathogenesis in thyroid cancer.
Article
Food Science & Technology
Chongyang Li, Yu Fu, Hongjie Dai, Qiang Wang, Ruichang Gao, Yuhao Zhang
Summary: Collagen peptides have great potential in improving UV-induced photoaging skin due to their diverse physiological activities. This article summarizes the main mechanisms and physiological activities of collagen peptides in improving photoaging skin, as well as their extraction and structural characteristics. Clinical trials on the beneficial effect of collagen peptides on skin are also discussed. The prospects and challenges of collagen peptides are emphasized in this review. Collagen peptides have the potential to be an effective ingredient in the food and cosmetics industry with wide application prospects.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Chenglei Tian, Dai Heng, Nannan Zhao, Linlin Liu, Xiaoyan Sheng, Jiyu Chen, Lin Liu
Summary: Functional telomeres are crucial for coordinated germ cell and somatic cell fate decisions by regulating TGF β and MAPK signaling to control germ cell specification.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo, Lina Wang, Wei-Guo Zhu, Wei Wang, Xiaoyun Liu, Shaokun Shu, Ying Zhao
Summary: Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment is crucial for tumor development, and the Lin28b/let-7 pathway plays a key role in modulating the expression of Wnt5a in tumor epithelium and cancer-associated fibroblasts.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Julia Ramirez-Moya, Leon Wert-Lamas, Pilar Santisteban
Article
Multidisciplinary Sciences
Junho Choe, Shuibin Lin, Wencai Zhang, Qi Liu, Longfei Wang, Julia Ramirez-Moya, Peng Du, Wantae Kim, Shaojun Tang, Piotr Sliz, Pilar Santisteban, Rani E. George, William G. Richards, Kwok-Kin Wong, Nicolas Locker, Frank J. Slack, Richard I. Gregory
Article
Biochemistry & Molecular Biology
Julia Ramirez-Moya, Leon Wert-Lamas, Garcilaso Riesco-Eizaguirre, Pilar Santisteban
Article
Multidisciplinary Sciences
Julia Ramirez-Moya, Leon Wert-Lamas, Adrian Acuna-Ruiz, Miguel A. Zabellos, Pilar Santisteban
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Biochemistry & Molecular Biology
Julia Ramirez-Moya, Allison R. Baker, Frank J. Slack, Pilar Santisteban
Article
Endocrinology & Metabolism
Julia Ramirez-Moya, Pilar Santisteban
Summary: The study revealed a molecular link between DICER1 and thyroid cell differentiation pathways, showing that DICER1 forms a positive feedback loop with differentiation transcription factors NKX2.1, PAX8, and CREB. This interaction affects thyroid cancer progression and treatment, providing insights into the downregulation of DICER1 in thyroid cancer.
Article
Biochemistry & Molecular Biology
Julia Ramirez-Moya, Christos Miliotis, Allison R. Baker, Richard Gregory, Frank J. Slack, Pilar Santisteban
Summary: ADAR1 deregulation leads to increased A-to-I editing in thyroid tumors, with CDK13 being identified as an oncogene that is significantly over-edited in tumor samples. This editing event promotes cancer cell hallmarks and increases the nucleolar abundance of the protein, potentially explaining the global splicing changes induced by ADAR1 deregulation.
Article
Endocrinology & Metabolism
Jelena Jankovic Miljus, Maria Augusta Guillen-Sacoto, Jennifer Makiadi-Alvarado, Leon Wert-Lamas, Julia Ramirez-Moya, Mercedes Robledo, Pilar Santisteban, Garcilaso Riesco-Eizaguirre
Summary: This study identified two putative novel miRNAs that rise with rhTSH stimulation in the serums of patients with recurrent/persistent thyroid cancer. However, known miRNAs were not found to be circulating markers for thyroid cancer recurrence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Allison R. Baker, Christos Miliotis, Julia Ramirez-Moya, Talia Marc, Ioannis S. Vlachos, Pilar Santisteban, Frank J. Slack
Summary: ADAR1 plays a critical role in triple-negative breast cancer, and its loss leads to reduced cell growth, invasion, and mammosphere formation. ADAR1 regulates both coding and noncoding targets by altering gene expression level, A-to-I editing, and splicing. The study also reveals that several tumor suppressor miRNAs are upregulated upon ADAR1 loss, suppressing cell-cycle progression and invasion.
MOLECULAR CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Julia Ramirez-Moya, Leon Wert-Lamas, Adrian Acuna-Ruiz, Alice Fletcher, Carlos Wert-Carvajal, Christopher J. McCabe, Pilar Santisteban, Garcilaso Riesco-Eizaguirre
Summary: Thyroid cancer is a rapidly increasing malignancy, and long non-coding RNAs (lncRNAs) play important roles in its progression. SPTY2D1-AS1, a downregulated lncRNA, has been identified as a tumor suppressor in thyroid cancer and a potential therapeutic target.
SCIENTIFIC REPORTS
(2022)
