Carbohydrate Sensing Through the Transcription Factor ChREBP

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase

(2018) Phillip J. White et al.   Cell Metabolism

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

(2018) Albert G. Linden et al.   JOURNAL OF LIPID RESEARCH

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity

(2018) Julien Bricambert et al.   Nature Communications

ChREBP Rather Than SHP Regulates Hepatic VLDL Secretion

(2018) Hiroyuki Niwa et al.   Nutrients

ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption

(2018) Takehiro Kato et al.   Nutrients

Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity

(2017) Deqiang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

MondoA/ChREBP: The usual suspects of transcriptional glucose sensing; Implication in pathophysiology

(2017) Paul Richards et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Validation, Identification, and Biological Consequences of the Site-specific O -GlcNAcylation Dynamics of Carbohydrate-responsive Element-binding Protein (ChREBP)

(2017) An-Qi Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Hepatocellular glycogenotic foci after combined intraportal pancreatic islet transplantation and knockout of the carbohydrate responsive element binding protein in diabetic mice

(2017) Silvia Ribback et al.   Oncotarget

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

(2017) Archana Vijayakumar et al.   Cell Reports

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

(2017) Alison Iroz et al.   Cell Reports

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice

(2017) Tara Jois et al.   Molecular Metabolism

FGF21 Regulates Sweet and Alcohol Preference

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP)

(2016) Shogo Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Biosynthesis of milk fat, protein, and lactose: roles of transcriptional and posttranscriptional regulation

(2016) Johan S. Osorio et al.   PHYSIOLOGICAL GENOMICS

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes

(2016) Parmveer Singh et al.   PLoS One

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin

(2015) Naravat Poungvarin et al.   ENDOCRINOLOGY

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

(2015) Jody R. Dushay et al.   Molecular Metabolism

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Metabolite Regulation of Nucleo-cytosolic Trafficking of Carbohydrate Response Element-binding Protein (ChREBP)

(2013) Tsutomu Nakagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Characterization of a Unique Interface between Carbohydrate Response Element-binding Protein (ChREBP) and 14-3-3β Protein

(2012) Qiang Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

A Novel N-Terminal Domain May Dictate the Glucose Response of Mondo Proteins

(2012) Lisa G. McFerrin et al.   PLoS One

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver

(2011) Renaud Dentin et al.   JOURNAL OF HEPATOLOGY

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

Coordinate regulation/localization of the carbohydrate responsive binding protein (ChREBP) by two nuclear export signal sites: Discovery of a new leucine-rich nuclear export signal site

(2009) Masashi Fukasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP

(2009) Susan J. Burke et al.   FASEB JOURNAL

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

(2009) Katsumi Iizuka et al.   FEBS LETTERS

Regulation of Nuclear Import/Export of Carbohydrate Response Element-binding Protein (ChREBP)

(2008) Haruhiko Sakiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Activates ChREBP by Increasing Its Rate of Nuclear Entry and Relieving Repression of Its Transcriptional Activity

(2008) Michael N. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY