Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model

Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy

(2018) Delia M. Talos et al.   ANNALS OF NEUROLOGY

mTOR dysregulation and tuberous sclerosis-related epilepsy

(2018) Paolo Curatolo et al.   Expert Review of Neurotherapeutics

Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia–associated epilepsy

(2018) Théo Ribierre et al.   JOURNAL OF CLINICAL INVESTIGATION

Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1

(2018) Katelyn N. Benthall et al.   Cell Reports

mTOR dysregulation and tuberous sclerosis-related epilepsy

(2018) Paolo Curatolo et al.   Expert Review of Neurotherapeutics

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

PI3K–mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models

(2016) Fan Lin et al.   CLINICAL CANCER RESEARCH

Causes of mortality in individuals with tuberous sclerosis complex

(2016) Sam Amin et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Interdependence of clinical factors predicting cognition in children with tuberous sclerosis complex

(2016) I. E. Overwater et al.   JOURNAL OF NEUROLOGY

Sudden unexpected death in epilepsy: epidemiology, mechanisms, and prevention

(2016) Orrin Devinsky et al.   LANCET NEUROLOGY

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug

(2016) Torbjörn Tomson et al.   LANCET NEUROLOGY

Sirolimus for epilepsy in children with tuberous sclerosis complex

(2016) Iris E. Overwater et al.   NEUROLOGY

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

(2016) Thomas J. Younts et al.   NEURON

mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis

(2016) Rita Citraro et al.   PHARMACOLOGICAL RESEARCH

The role of antiepileptic drugs in sudden unexpected death in epilepsy

(2016) Dag Aurlien et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

(2016) Nicole A. Hawkins et al.   PLoS Genetics

Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex

(2015) Nicholas Rensing et al.   EPILEPSIA

Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs

(2015) Iris E. Overwater et al.   EPILEPSIA

Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments

(2015) S. M. I. Goorden et al.   HUMAN MOLECULAR GENETICS

HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1

(2015) A Omrani et al.   MOLECULAR PSYCHIATRY

Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models

(2015) Isamu Aiba et al.   Science Translational Medicine

Adenosine Triphosphate-Competitive mTOR Inhibitors: A New Class of Immunosuppressive Agents That Inhibit Allograft Rejection

(2014) B. R. Rosborough et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α2- versus α1-GABAA–Receptor Complexes

(2014) Henrik Sindal Jensen et al.   PLoS One

FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity

(2014) Christopher M. Bartley et al.   PLoS One

TORC1-dependent epilepsy caused by acute biallelicTsc1deletion in adult mice

(2013) Elisabeth Abs et al.   ANNALS OF NEUROLOGY

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex

(2013) Bo Zhang et al.   PLoS One

Structural basis of AMPK regulation by small molecule activators

(2013) Bing Xiao et al.   Nature Communications

Sudden Unexpected Death in Epilepsy

(2012) Dale C. Hesdorffer et al.   CNS DRUGS

mTOR Inhibitors in Tuberous Sclerosis Complex

(2012) Paolo Curatolo et al.   Current Neuropharmacology

Understanding relationships between autism, intelligence, and epilepsy: a cross-disorder approach

(2012) AGNIES M van EEGHEN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations

(2012) Paolo Curatolo et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Time-Dependent Modulation of Mitogen Activated Protein Kinases and AKT in Rat Hippocampus and Cortex in the Pilocarpine Model of Epilepsy

(2012) Mark William Lopes et al.   NEUROCHEMICAL RESEARCH

Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

(2011) Laura Magri et al.   Cell Stem Cell

Long-term neurological outcome in children with early-onset epilepsy associated with tuberous sclerosis

(2011) Raffaella Cusmai et al.   EPILEPSY & BEHAVIOR

Low glycemic index treatment for epilepsy in tuberous sclerosis complex

(2011) Anna M. Larson et al.   EPILEPSY RESEARCH

Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex

(2011) Sergiusz Jóźwiak et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

(2011) Sharon S. McDaniel et al.   NEUROSCIENCE LETTERS

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

(2011) J. Goto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model

(2010) Jarogniew J. Luszczki et al.   EPILEPSY RESEARCH

Targeted treatments for cognitive and neurodevelopmental disorders in tuberous sclerosis complex

(2010) Petrus J. Vries   Neurotherapeutics

The tuberous sclerosis complex

(2009) Ksenia A. Orlova et al.   Annals of the New York Academy of Sciences

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

The natural history of epilepsy in tuberous sclerosis complex

(2009) Catherine J. Chu-Shore et al.   EPILEPSIA

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET