Peptide therapeutics and assemblies for cancer immunotherapy

Blood Circulation-Prolonging Peptides for Engineered Nanoparticles Identified via Phage Display

(2019) Peipei Jin et al.   NANO LETTERS

Quantitatively Visualizing Tumor-Related Protease Activity in Vivo Using a Ratiometric Photoacoustic Probe

(2019) Ling Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor Microenvironment Responsive Drug‐Dye‐Peptide Nanoassembly for Enhanced Tumor‐Targeting, Penetration, and Photo‐Chemo‐Immunotherapy

(2019) Jinrong Peng et al.   ADVANCED FUNCTIONAL MATERIALS

Linear Chimeric Triblock Molecules Self‐Assembled Micelles with Controllably Transformable Property to Enhance Tumor Retention for Chemo‐Photodynamic Therapy of Breast Cancer

(2019) Rui Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

(2018) Wen Song et al.   ACS Nano

Laser Immunotherapy in Combination with Perdurable PD-1 Blocking for Treatment of Metastatic Tumor

(2018) Lihua Luo et al.   ACS Nano

iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma

(2018) Jing Kuang et al.   ADVANCED FUNCTIONAL MATERIALS

Injectable Bioresponsive Gel Depot for Enhanced Immune Checkpoint Blockade

(2018) Shuangjiang Yu et al.   ADVANCED MATERIALS

Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid

(2018) Qingqing Miao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross-Linked Peptide Nanoclusters for Delivery of Oncofetal Antigen as a Cancer Vaccine

(2018) Alexandra N. Tsoras et al.   BIOCONJUGATE CHEMISTRY

Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses

(2018) Medea Neek et al.   BIOMATERIALS

Conjugation Chemistry-Dependent T-Cell Activation with Spherical Nucleic Acids

(2018) Kacper Skakuj et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma

(2018) Rie Wakabayashi et al.   MOLECULAR PHARMACEUTICS

Engineering Dendritic-Cell-Based Vaccines and PD-1 Blockade in Self-Assembled Peptide Nanofibrous Hydrogel to Amplify Antitumor T-Cell Immunity

(2018) Pengxiang Yang et al.   NANO LETTERS

Sequentially Responsive Therapeutic Peptide Assembling Nanoparticles for Dual-Targeted Cancer Immunotherapy

(2018) Keman Cheng et al.   NANO LETTERS

Immunotherapy: Cancer immunotherapy and the value of cure

(2018) Joseph C. Del Paggio   Nature Reviews Clinical Oncology

Personalized vaccines for cancer immunotherapy

(2018) Ugur Sahin et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

(2018) Tingting Wang et al.   Nature Communications

Recent Progresses in Phototherapy-Synergized Cancer Immunotherapy

(2018) Chee Wee Ng et al.   ADVANCED FUNCTIONAL MATERIALS

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

(2018) Tingkai Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination

(2017) Mazda Rad-Malekshahi et al.   MOLECULAR PHARMACEUTICS

Cancer vaccines using supramolecular hydrogels of NSAID-modified peptides as adjuvants abolish tumorigenesis

(2017) Zhongyan Wang et al.   Nanoscale

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Chimeric antigen receptor T-cell therapies for lymphoma

(2017) Jennifer N. Brudno et al.   Nature Reviews Clinical Oncology

Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies

(2017) David J. Byun et al.   Nature Reviews Endocrinology

Encapsulation of Hydrophilic and Hydrophobic Peptides into Hollow Mesoporous Silica Nanoparticles for Enhancement of Antitumor Immune Response

(2017) Jun Xie et al.   Small

Discovery and design of self-assembling peptides

(2017) Shuguang Zhang   Interface Focus

Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy

(2017) Chunlin Li et al.   Cancer Immunology Research

Single Dose of Protein Vaccine with Peptide Nanofibers As Adjuvants Elicits Long-Lasting Antibody Titer

(2017) Chengbiao Yang et al.   ACS Biomaterials-Science & Engineering

Single Dose of Protein Vaccine with Peptide Nanofibers As Adjuvants Elicits Long-Lasting Antibody Titer

(2017) Chengbiao Yang et al.   ACS Biomaterials Science & Engineering

CAR-T Cell Therapy: From the Bench to the Bedside

(2017) Vita Golubovskaya   Cancers

Enzyme-Catalyzed Formation of Supramolecular Hydrogels as Promising Vaccine Adjuvants

(2016) Huaimin Wang et al.   ADVANCED FUNCTIONAL MATERIALS

A Powerful CD8+T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant

(2016) Zichao Luo et al.   ADVANCED MATERIALS

CTLA-4 and PD-1 Pathways

(2016) Elizabeth I. Buchbinder et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer

(2016) Yu Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting dendritic cells in lymph node with an antigen peptide-based nanovaccine for cancer immunotherapy

(2016) Yuan Qian et al.   BIOMATERIALS

CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date

(2016) Jae H. Park et al.   BLOOD

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

(2016) Celine Boutros et al.   Nature Reviews Clinical Oncology

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Multitriggered Tumor-Responsive Drug Delivery Vehicles Based on Protein and Polypeptide Coassembly for Enhanced Photodynamic Tumor Ablation

(2016) Ning Zhang et al.   Small

Peptide-based synthetic vaccines

(2016) Mariusz Skwarczynski et al.   Chemical Science

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

(2016) Margit Mahlapuu et al.   Frontiers in Cellular and Infection Microbiology

PD-L1 peptide co-stimulation increases immunogenicity of a dendritic cell-based cancer vaccine

(2016) Shamaila Munir Ahmad et al.   OncoImmunology

Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma

(2015) Yuanyuan Guo et al.   ACS Nano

A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy

(2015) Ya Liu et al.   ADVANCED MATERIALS

Blocking of the PD-1/PD-L1 Interaction by aD-Peptide Antagonist for Cancer Immunotherapy

(2015) Hao-Nan Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Self-Assembling Peptide Scaffold for the Multivalent Presentation of Antigens

(2015) Elsa Zacco et al.   BIOMACROMOLECULES

Releasing the Brakes on Cancer Immunotherapy

(2015) Dan R. Littman   CELL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Peptide self-assembly for nanomaterials: the old new kid on the block

(2015) Emiliana De Santis et al.   CHEMICAL SOCIETY REVIEWS

Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy

(2015) Andrew B Sharabi et al.   LANCET ONCOLOGY

Gold nanocluster-based vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides

(2015) Yu Tao et al.   Nanoscale

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

(2015) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Enhancing the Magnitude of Antibody Responses through Biomaterial Stereochemistry

(2015) Rajagopal Appavu et al.   ACS Biomaterials-Science & Engineering

Enhancing the Magnitude of Antibody Responses through Biomaterial Stereochemistry

(2015) Rajagopal Appavu et al.   ACS Biomaterials Science & Engineering

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

Polyacrylate-Based Delivery System for Self-adjuvanting Anticancer Peptide Vaccine

(2014) Tzu-Yu Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer

(2014) Paula Cristina Batista de Faria et al.   NANO LETTERS

Recent advances in peptide-based subunit nanovaccines

(2014) Mariusz Skwarczynski et al.   Nanomedicine

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Gradated assembly of multiple proteins into supramolecular nanomaterials

(2014) Gregory A. Hudalla et al.   NATURE MATERIALS

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Peptide-based vaccines for cancer therapy

(2014) Giorgio Parmiani et al.   Human Vaccines & Immunotherapeutics

Self-Assembled Tat Nanofibers as Effective Drug Carrier and Transporter

(2013) Pengcheng Zhang et al.   ACS Nano

Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation

(2013) Nicholas M. Molino et al.   ACS Nano

Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer

(2013) Tzu-Yu Liu et al.   BIOMACROMOLECULES

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

(2013) Jianjun Chen et al.   BIOMATERIALS

CAR T cells: driving the road from the laboratory to the clinic

(2013) Eleanor J. Cheadle et al.   IMMUNOLOGICAL REVIEWS

Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery

(2013) Xianglong Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival

(2013) M. Cieslewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Modulating Adaptive Immune Responses to Peptide Self-Assemblies

(2012) Jai S. Rudra et al.   ACS Nano

Self-Assembled Peptide Amphiphile Micelles Containing a Cytotoxic T-Cell Epitope Promote a Protective Immune Response In Vivo

(2012) Matthew Black et al.   ADVANCED MATERIALS

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope

(2012) Jai S. Rudra et al.   BIOMATERIALS

Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

(2012) Sotirios Koutsopoulos et al.   JOURNAL OF CONTROLLED RELEASE

Safety and Immunogenicity of Vaccination With MART-1 (26–35, 27L), gp100 (209–217, 210M), and Tyrosinase (368–376, 370D) In Adjuvant With PF-3512676 and GM-CSF In Metastatic Melanoma

(2012) Ahmad A. Tarhini et al.   JOURNAL OF IMMUNOTHERAPY

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-Walled Carbon Nanotubes Deliver Peptide Antigen into Dendritic Cells and Enhance IgG Responses to Tumor-Associated Antigens

(2011) Carlos H. Villa et al.   ACS Nano

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A peptide-based material platform for displaying antibodies to engage T cells

(2010) Ying Zheng et al.   BIOMATERIALS

Self-assembly of peptide amphiphiles: From molecules to nanostructures to biomaterials

(2010) Honggang Cui et al.   BIOPOLYMERS

Peptides and Peptide Hormones for Molecular Imaging and Disease Diagnosis

(2010) Seulki Lee et al.   CHEMICAL REVIEWS

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-Assembly of Giant Peptide Nanobelts

(2009) Honggang Cui et al.   NANO LETTERS

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold

(2009) S. Koutsopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Clinical Trial Results of a HER2/neu (E75) Vaccine for the Prevention of Recurrence in High-Risk Breast Cancer Patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02

(2008) G. E. Peoples et al.   CLINICAL CANCER RESEARCH

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

Peptide Imprinted Polymer Nanoparticles: A Plastic Antibody

(2008) Yu Hoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE