High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients

Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients

(2018) Mei Liu et al.   Cellular & Molecular Immunology

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

CD19+CD24hiCD38hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-α

(2018) Christopher J. M. Piper et al.   Frontiers in Immunology

Cutting Edge: Intracellular IFN-β and Distinct Type I IFN Expression Patterns in Circulating Systemic Lupus Erythematosus B Cells

(2018) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus

(2018) Kei Sakata et al.   Frontiers in Immunology

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells

(2017) Jennie A. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 7 gene single nucleotide polymorphisms and the risk for systemic lupus erythematosus: a case-control study

(2017) I. I. Raafat et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

2017 ACR/ARHP Annual Meeting Abstract Supplement

(2017)   Arthritis & Rheumatology

Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus

(2016) John R. Doedens et al.   JOURNAL OF IMMUNOLOGY

Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus

(2015) Nan-Hua Chang et al.   JOURNAL OF AUTOIMMUNITY

Cell-Intrinsic Expression of TLR9 in Autoreactive B Cells Constrains BCR/TLR7-Dependent Responses

(2015) Kerstin Nündel et al.   JOURNAL OF IMMUNOLOGY

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

Advances in understanding the role of type I interferons in systemic lupus erythematosus

(2014) Mary K. Crow   CURRENT OPINION IN RHEUMATOLOGY

B Cell–Intrinsic TLR7 Signaling Is Essential for the Development of Spontaneous Germinal Centers

(2014) Chetna Soni et al.   JOURNAL OF IMMUNOLOGY

Expression of Toll-Like Receptors 3, 7, and 9 in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

(2014) Agnieszka Klonowska-Szymczyk et al.   MEDIATORS OF INFLAMMATION

Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs

(2014) Beverly D. Lyn-Cook et al.   MOLECULAR IMMUNOLOGY

Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus

(2014) X.-n. Wu et al.   Science Translational Medicine

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population

(2014) Chin-Man Wang et al.   Scientific Reports

Distinct Autoantibody Profiles in Systemic Lupus Erythematosus Patients are Selectively Associated with TLR7 and TLR9 Upregulation

(2013) Sudhir Kumar Chauhan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

(2013) Natalia V. Giltiay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

(2013) A. Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Type I IFN Drives Emergency Myelopoiesis and Peripheral Myeloid Expansion during Chronic TLR7 Signaling

(2013) M. B. Buechler et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

(2013) Yun Deng et al.   PLoS Genetics

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR9 drives the development of transitional B cells towards the marginal zone pathway and promotes autoimmunity

(2012) Thomas Guerrier et al.   JOURNAL OF AUTOIMMUNITY

B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus-Prone Mice

(2012) S.-H. Hwang et al.   JOURNAL OF IMMUNOLOGY

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

(2012) E Åhlin et al.   LUPUS

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

(2011) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

(2010) H. Garcia-Ortiz et al.   ANNALS OF THE RHEUMATIC DISEASES

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

(2010) A. Komatsuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus

(2010) Souichiro Nakano et al.   RHEUMATOLOGY

Regulation of the interferon-α production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

(2009) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy

(2009) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95

(2008) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE