Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling

Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses

(2018) Matteo Ugolini et al.   NATURE IMMUNOLOGY

Human genetics of infectious diseases: Unique insights into immunological redundancy

(2018) Jean-Laurent Casanova et al.   SEMINARS IN IMMUNOLOGY

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling

(2018) Dominic De Nardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG

(2018) Zhi-Jun Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

(2018) Mikhail V. Pashenkov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule inhibition of TLR8 through stabilization of its resting state

(2017) Shuting Zhang et al.   Nature Chemical Biology

Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts

(2017) Erika Della Mina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation

(2017) Tim Vierbuchen et al.   Frontiers in Immunology

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages

(2017) Birgitta Ehrnström et al.   Frontiers in Immunology

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

(2016) Jing Sun et al.   Science Signaling

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

(2015) A. Kru ger et al.   EMBO REPORTS

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition ofStreptococcus pyogenes

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Interleukin-1β/CXCL1/2/Neutrophil Axis Mediates Host Protection against Group B Streptococcal Infection

(2014) C. Biondo et al.   INFECTION AND IMMUNITY

Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells

(2014) Noriko Ishii et al.   JOURNAL OF IMMUNOLOGY

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Essential Role of Interleukin-1 Signaling in Host Defenses Against Group B Streptococcus

(2014) C. Biondo et al.   mBio

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR2 Signaling Depletes IRAK1 and Inhibits Induction of Type I IFN by TLR7/9

(2012) Y. C. Liu et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of TNF induction by heat-killed Staphylococcus aureus differ upon the origin of mononuclear phagocytes

(2011) Ronan Kapetanovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

(2010) Capucine Picard et al.   MEDICINE

Synergistic regulation ofPseudomonas aeruginosa-induced cytokine production in human monocytes by mannose receptor and TLR2

(2009) Panagiota Xaplanteri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition

(2009) Jin Liu et al.   MOLECULAR IMMUNOLOGY

Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature

(2009) K. T. Lappegard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

(2008) Yun-Gi Kim et al.   IMMUNITY