Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophages

(2015) Ning Li et al.   Scientific Reports

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

(2014) Jonathan L. Schmid-Burgk et al.   GENOME RESEARCH

A Cross-Disciplinary Perspective on the Innate Immune Responses to Bacterial Lipopolysaccharide

(2014) Yunhao Tan et al.   MOLECULAR CELL

Genomic responses in mouse models greatly mimic human inflammatory diseases

(2014) Keizo Takao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages

(2013) Souhaila Al-Khodor et al.   CELLULAR MICROBIOLOGY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fine mapping of Xq28: bothMECP2 and IRAK1contribute to risk for systemic lupus erythematosus in multiple ancestral groups

(2012) Kenneth M Kaufman et al.   ANNALS OF THE RHEUMATIC DISEASES

IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis

(2012) Hui Zhang et al.   RHEUMATOLOGY INTERNATIONAL

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

(2011) Nicolas Chevrier et al.   CELL

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

(2011) Sinead M. Flannery et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune Complex-Mediated Cell Activation from Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients Elaborate Different Requirements for IRAK1/4 Kinase Activity across Human Cell Types

(2010) E. Y. Chiang et al.   JOURNAL OF IMMUNOLOGY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Interleukin-1 Receptor-associated Kinase 2 Is Critical for Lipopolysaccharide-mediated Post-transcriptional Control

(2009) Youzhong Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses

(2009) I. Amit et al.   SCIENCE

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

Forward genetic analysis of TLR-signaling pathways: An evaluation☆

(2008) K HOEBE et al.   ADVANCED DRUG DELIVERY REVIEWS

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages

(2008) Dominic De Nardo et al.   CELLULAR SIGNALLING

Gene-specific control of the TLR-induced inflammatory response

(2008) Simmie L. Foster et al.   CLINICAL IMMUNOLOGY

The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Toll-like Receptor-induced TAK1-dependent NFκB Activation

(2008) Jerzy Frączek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

The art and design of genetic screens: RNA interference

(2008) Michael Boutros et al.   NATURE REVIEWS GENETICS