Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1

CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)

(2018) Meng-Meng Li et al.   CLINICAL IMMUNOLOGY

Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)

(2018) Meng-Meng Li et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase–IRF3 transcription factor interaction and signaling required for interferon induction

(2017) Yun-Jia Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Neonatal Murine Model of Coxsackievirus A6 Infection for Evaluation of Antiviral and Vaccine Efficacy

(2017) Zhenjie Zhang et al.   JOURNAL OF VIROLOGY

Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism

(2017) Patricia M. Day et al.   JOURNAL OF VIROLOGY

Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome

(2017) Miao-Miao Liu et al.   Virology Journal

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

(2017) Peixin Song et al.   Scientific Reports

Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

(2017) Yun-Jia Ning et al.   Protein & Cell

Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism

(2017) Yuchen Nan et al.   Frontiers in Immunology

Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China

(2017) Yanfang Zhang et al.   VIROLOGICA SINICA

Modeling Severe Fever with Thrombocytopenia Syndrome Virus Infection in Golden Syrian Hamsters: Importance of STAT2 in Preventing Disease and Effective Treatment with Favipiravir

(2016) Brian B. Gowen et al.   JOURNAL OF VIROLOGY

Phleboviruses and the Type I Interferon Response

(2016) Jennifer Wuerth et al.   Viruses-Basel

PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus

(2016) Zhi-Sheng Xu et al.   Journal of Molecular Cell Biology

Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments

(2016) Katharina S. Schulz et al.   Frontiers in Immunology

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

(2015) Vidyanath Chaudhary et al.   JOURNAL OF GENERAL VIROLOGY

Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies

(2015) Yun-Jia Ning et al.   JOURNAL OF VIROLOGY

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

RIG-I in RNA virus recognition

(2015) Alison M. Kell et al.   VIROLOGY

Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response

(2015) Yong Ran et al.   Journal of Molecular Cell Biology

Interferon-γ Inhibits Ebola Virus Infection

(2015) Bethany A. Rhein et al.   PLoS Pathogens

Interferons: Success in anti-viral immunotherapy

(2014) Fan-ching Lin et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus

(2014) Xiaodong Wu et al.   FASEB JOURNAL

Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses

(2014) F. W. Santiago et al.   JOURNAL OF VIROLOGY

Comprehensive Molecular Detection of Tick-Borne Phleboviruses Leads to the Retrospective Identification of Taxonomically Unassigned Bunyaviruses and the Discovery of a Novel Member of the Genus Phlebovirus

(2014) Keita Matsuno et al.   JOURNAL OF VIROLOGY

Concurrent Measurement of Dynamic Changes in Viral Load, Serum Enzymes, T Cell Subsets, and Cytokines in Patients with Severe Fever with Thrombocytopenia Syndrome

(2014) Jun Li et al.   PLoS One

Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform

(2014) Yun-Jia Ning et al.   Journal of Molecular Cell Biology

The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan

(2013) Toru Takahashi et al.   JOURNAL OF INFECTIOUS DISEASES

Evasion of Antiviral Immunity through Sequestering of TBK1/IKK /IRF3 into Viral Inclusion Bodies

(2013) X. Wu et al.   JOURNAL OF VIROLOGY

The Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus Infection in Alpha/Beta Interferon Knockout Mice: Insights into the Pathologic Mechanisms of a New Viral Hemorrhagic Fever

(2013) Y. Liu et al.   JOURNAL OF VIROLOGY

Inborn Errors of Human JAKs and STATs

(2012) Jean-Laurent Casanova et al.   IMMUNITY

Infection and pathogenesis of Huaiyangshan virus (a novel tick-borne bunyavirus) in laboratory rodents

(2012) X.-P. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Host Cytokine Storm Is Associated With Disease Severity of Severe Fever With Thrombocytopenia Syndrome

(2012) Y. Sun et al.   JOURNAL OF INFECTIOUS DISEASES

Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus

(2012) D. Hou et al.   JOURNAL OF VIROLOGY

Suppression of the Interferon and NF-κB Responses by Severe Fever with Thrombocytopenia Syndrome Virus

(2012) Bingqian Qu et al.   JOURNAL OF VIROLOGY

A New Phlebovirus Associated with Severe Febrile Illness in Missouri

(2012) Laura K. McMullan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine and Chemokine Levels in Patients with Severe Fever with Thrombocytopenia Syndrome Virus

(2012) Baocheng Deng et al.   PLoS One

LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection

(2012) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

(2012) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemorrhagic Fever Caused by a Novel Bunyavirus in China: Pathogenesis and Correlates of Fatal Outcome

(2011) Yong-Zhen Zhang et al.   CLINICAL INFECTIOUS DISEASES

Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China

(2011) Xue-Jie Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

Metagenomic Analysis of Fever, Thrombocytopenia and Leukopenia Syndrome (FTLS) in Henan Province, China: Discovery of a New Bunyavirus

(2011) Bianli Xu et al.   PLoS Pathogens

STAT1 and pathogens, not a friendly relationship

(2010) Imen Najjar et al.   BIOCHIMIE

Gene modulation and immunoregulatory roles of Interferonγ

(2009) Banishree Saha et al.   CYTOKINE

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-α/β, IFN-γ, and IFN-λ in host defense

(2009) Shen-Ying Zhang et al.   IMMUNOLOGICAL REVIEWS

Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

(2008) Fernando A Bozza et al.   BMC INFECTIOUS DISEASES

Cytokine Polymorphisms Have a Synergistic Effect on Severity of the Acute Sickness Response to Infection

(2008) Uté Vollmer‐Conna et al.   CLINICAL INFECTIOUS DISEASES