The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be

Systemic Lupus Erythematosus: Definitions, Contexts, Conflicts, Enigmas

(2018) Ole Petter Rekvig   Frontiers in Immunology

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

(2018) Mona H. C. Biermann et al.   Frontiers in Immunology

Missing in action-The meaning of cell death in tissue damage and inflammation

(2017) Luis E. Muñoz et al.   IMMUNOLOGICAL REVIEWS

Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis

(2017) Nils Rother et al.   Frontiers in Immunology

B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains

(2017) Nishant Dwivedi et al.   Frontiers in Immunology

Future Perspectives on Pathogenesis of Lupus Nephritis

(2016) Ole P. Rekvig et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus

(2016) Sylviane Muller et al.   NATURE MEDICINE

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

DNA-damaging autoantibodies and cancer: the lupus butterfly theory

(2016) Philip W. Noble et al.   Nature Reviews Rheumatology

Infection and Lupus: Which Causes Which?

(2016) Sarah Doaty et al.   Current Rheumatology Reports

NETosis – Does It Really Represent Nature’s “Suicide Bomber”?

(2016) Shida Yousefi et al.   Frontiers in Immunology

New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

(2016) Hang Yang et al.   Frontiers in Immunology

Autoantibodies against Modified Histone Peptides in SLE Patients Are Associated with Disease Activity and Lupus Nephritis

(2016) Jürgen Dieker et al.   PLoS One

A volcanic explosion of autoantibodies in systemic lupus erythematosus: A diversity of 180 different antibodies found in SLE patients

(2015) Gal Yaniv et al.   AUTOIMMUNITY REVIEWS

Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

(2015) Félix Fernández Madrid et al.   BMC CANCER

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies

(2015) M. Jiménez-Alcázar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The anti-DNA antibody: origin and impact, dogmas and controversies

(2015) Ole P. Rekvig   Nature Reviews Rheumatology

Anti-DNA antibodies — quintessential biomarkers of SLE

(2015) David S. Pisetsky   Nature Reviews Rheumatology

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Murine and Human Lupus Nephritis: Pathogenic Mechanisms and Theoretical Strategies for Therapy

(2015) Hege Lynum Pedersen et al.   SEMINARS IN NEPHROLOGY

The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

(2015) Beatrice Goilav et al.   SEMINARS IN NEPHROLOGY

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE

(2014) David S. Pisetsky   AUTOIMMUNITY

Anti-dsDNA antibodies as a classification criterion and a diagnostic marker for systemic lupus erythematosus: critical remarks

(2014) O. P. Rekvig   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Lupus nephritis

(2014) Georg Lorenz et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

(2014) Nishant Dwivedi et al.   FASEB JOURNAL

Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus

(2014) Tony N. Marion et al.   Seminars in Immunopathology

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

(2014) Elmar Pieterse et al.   Frontiers in Immunology

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity

(2013) Nishant Dwivedi et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-DNA antibodies cross-react with C1q

(2013) Giovanni Franchin et al.   JOURNAL OF AUTOIMMUNITY

Cancer risk in systemic lupus: An updated international multi-centre cohort study

(2013) Sasha Bernatsky et al.   JOURNAL OF AUTOIMMUNITY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unknown

(2013) Natalya Seredkina et al.   MOLECULAR MEDICINE

NETs: the missing link between cell death and systemic autoimmune diseases?

(2013) Erika Darrah et al.   Frontiers in Immunology

When autologous chromatin becomes a foe

(2012) Luis E. Muñoz et al.   AUTOIMMUNITY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

(2012) Meera R. Krishnan et al.   KIDNEY INTERNATIONAL

Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e

(2012) Dhivya Thiyagarajan et al.   PLoS One

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Acquired Loss of Renal Nuclease Activity Is Restricted to DNaseI and Is an Organ-Selective Feature in Murine Lupus Nephritis

(2011) Natalya Seredkina et al.   AMERICAN JOURNAL OF PATHOLOGY

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Serologic Laboratory Findings in Malignancy

(2011) Félix Fernández Madrid et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Lupus Nephritis: Role of Antinucleosome Autoantibodies

(2011) Johan van der Vlag et al.   SEMINARS IN NEPHROLOGY

Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus

(2010) C. C. van Bavel et al.   ANNALS OF THE RHEUMATIC DISEASES

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

(2010) Kristin Kruse et al.   APOPTOSIS

Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice

(2010) Kristin Andreassen Fenton et al.   AUTOIMMUNITY

Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66

(2010) Wei Zhang et al.   AUTOIMMUNITY

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

(2009) Luis E. Muñoz et al.   ARTHRITIS AND RHEUMATISM

Antibodies to DNA: infection or genetics?

(2009) DS Pisetsky et al.   LUPUS

Circulating chromatin–anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis

(2009) S Fismen et al.   LUPUS

The role of microparticles in the pathogenesis of rheumatic diseases

(2009) Christian Beyer et al.   Nature Reviews Rheumatology

Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 Mice

(2009) Kristin Fenton et al.   PLoS One

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

(2009) D. H. Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glomerular targets of nephritogenic autoantibodies in systemic lupus erythematosus

(2008) Casandra C. van Bavel et al.   ARTHRITIS AND RHEUMATISM

Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZB×NZW)F1 mice

(2008) Janne Erikke Mjelle et al.   AUTOIMMUNITY

An Anti-Double-Stranded DNA Monoclonal Antibody Induced by Tumor Cell–Derived DNA Inhibits the Growth of Tumor In Vitro and In Vivo via Triggering Apoptosis

(2007) Qinghua Cao et al.   DNA AND CELL BIOLOGY