Divergent impact of Toll-like receptor 2 deficiency on repair mechanisms in healthy muscle versus Duchenne muscular dystrophy

Toll-Like Receptor 2-Dependent Extracellular Signal-Regulated Kinase Signaling in Mycobacterium tuberculosis-Infected Macrophages Drives Anti-Inflammatory Responses and Inhibits Th1 Polarization of Responding T Cells

(2015) Edward T. Richardson et al.   INFECTION AND IMMUNITY

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis

(2015) Mukanthu H. Nyirenda et al.   JOURNAL OF IMMUNOLOGY

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

(2015) Yetrib Hathout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 ablation in mdx mice reveals innate immunity as a therapeutic target in Duchenne muscular dystrophy

(2015) Christian Giordano et al.   HUMAN MOLECULAR GENETICS

Shared signaling systems in myeloid cell-mediated muscle regeneration

(2014) J. G. Tidball et al.   DEVELOPMENT

Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

(2014) K. Mojumdar et al.   EMBO Molecular Medicine

Discovery of serum protein biomarkers in the mdx mouse model and cross-species comparison to Duchenne muscular dystrophy patients

(2014) Yetrib Hathout et al.   HUMAN MOLECULAR GENETICS

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

(2014) Sherry Dadgar et al.   JOURNAL OF CELL BIOLOGY

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

(2014) S. A. Villalta et al.   Science Translational Medicine

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration

(2013) Marielle Saclier et al.   FEBS Journal

Role of toll-like receptors in the pathogenesis of dystrophin-deficient skeletal and heart muscle

(2013) A. Henriques-Pons et al.   HUMAN MOLECULAR GENETICS

The effects of MyD88 deficiency on disease phenotype in dysferlin-deficient A/J mice: role of endogenous TLR ligands

(2013) Kitipong Uaesoontrachoon et al.   JOURNAL OF PATHOLOGY

Muscular dystrophies

(2013) Eugenio Mercuri et al.   LANCET

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll‐Like Receptor‐2 Mediates Adaptive Cardiac Hypertrophy in Response to Pressure Overload Through Interleukin‐1β Upregulation via Nuclear Factor κB Activation

(2013) Yasutomi Higashikuni et al.   Journal of the American Heart Association

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair

(2011) Haiyan Lu et al.   FASEB JOURNAL

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury

(2011) Conrad A. Farrar et al.   FASEB JOURNAL

Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands

(2011) Chao Shi et al.   IMMUNITY

Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: Balancing muscle protection and destruction

(2011) Boel De Paepe et al.   NEUROMUSCULAR DISORDERS

Regulation of skeletal muscle regeneration by CCR2-activating chemokines is directly related to macrophage recruitment

(2010) Carlo O. Martinez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Left ventricular dilation in toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation

(2010) Jan Mersmann et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

(2009) Sylvia A. Vetrone et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat Shock Protein 96 Is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily via TLR2 Signaling

(2009) Q.-Q. Huang et al.   JOURNAL OF IMMUNOLOGY

The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls

(2008) Lilian O. Moreira et al.   CELLULAR MICROBIOLOGY

Bone marrow-derived cell regulation of skeletal muscle regeneration

(2008) Dongxu Sun et al.   FASEB JOURNAL

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT

Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy

(2008) S. A. Villalta et al.   HUMAN MOLECULAR GENETICS

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

CC family chemokines directly regulate myoblast responses to skeletal muscle injury

(2008) Linda Yahiaoui et al.   JOURNAL OF PHYSIOLOGY-LONDON

Macrophage activation by endogenous danger signals

(2007) X Zhang et al.   JOURNAL OF PATHOLOGY