The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis

(2019) Kristen E. Funk et al.   Journal of Neuroinflammation

Microglia are required for protection against lethal coronavirus encephalitis in mice

(2018) D. Lori Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate Immune Responses and Viral-Induced Neurologic Disease

(2018) Yuting Cheng et al.   Journal of Clinical Medicine

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

(2017) Raymond Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination

(2016) Brett S. Marro et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease

(2016) Laura L. Dickey et al.   Journal of Neuroinflammation

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Guillain–Barré Syndrome Associated with Zika Virus Infection in Colombia

(2016) Beatriz Parra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibiotic use and its consequences for the normal microbiome

(2016) Martin J. Blaser   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Sphingosine-1-Phosphate Receptor Antagonism Enhances Proliferation and Migration of Engrafted Neural Progenitor Cells in a Model of Viral-Induced Demyelination

(2015) Caroline A. Blanc et al.   AMERICAN JOURNAL OF PATHOLOGY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep–wake regulatory neurons in mice

(2015) Chiara Tesoriero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: unique and common features with other tissue macrophages

(2014) Marco Prinz et al.   ACTA NEUROPATHOLOGICA

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination

(2014) Caroline A Blanc et al.   Journal of Neuroinflammation

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis

(2014) M. L. Greenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling

(2014) Yan Wang et al.   Nature Communications

Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis

(2014) Lu Chen et al.   Stem Cell Reports

Viruses and the Microbiota

(2014) Christopher M. Robinson et al.   Annual Review of Virology

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Virus Infections in the Nervous System

(2013) Orkide O. Koyuncu et al.   Cell Host & Microbe

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

T cell mediated suppression of neurotropic coronavirus replication in neural precursor cells

(2013) Warren C. Plaisted et al.   VIROLOGY

Viruses and Multiple Sclerosis

(2012) Jussi Oskari Virtanen et al.   CNS & Neurological Disorders-Drug Targets

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Toll-Like Receptors Promote Mutually Beneficial Commensal-Host Interactions

(2012) Jason L. Kubinak et al.   PLoS Pathogens

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral triggers of multiple sclerosis

(2010) Kristina Kakalacheva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathogenesis of Murine Coronavirus in the Central Nervous System

(2010) Susan J. Bender et al.   Journal of Neuroimmune Pharmacology

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis

(2010) K. S. Carbajal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Infection Leading to Brain Dysfunction: More Prevalent Than Appreciated?

(2009) Anthony N. van den Pol   NEURON

Role of regulatory T cells in coronavirus-induced acute encephalitis

(2009) Daniela Anghelina et al.   VIROLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE