The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

(2018) Purva Singh et al.   Annals of the New York Academy of Sciences

Roles of osmolytes in protein folding and aggregation in cells and their biotechnological applications

(2018) Gulam Rabbani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Physiological and Pathological Functions of Cl− Channels in Chondrocytes

(2018) Hisao Yamamura et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Models of osteoarthritis: the good, the bad and the promising

(2018) P.J. Cope et al.   OSTEOARTHRITIS AND CARTILAGE

Chasing Chimeras – The elusive stable chondrogenic phenotype

(2018) Valeria Graceffa et al.   BIOMATERIALS

The clustering and morphology of chondrocytes in normal and mildly degenerate human femoral head cartilage studied by confocal laser scanning microscopy

(2017) Asima Karim et al.   JOURNAL OF ANATOMY

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis

(2017) Tengfei Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

(2017) Peter M. van der Kraan   Nature Reviews Rheumatology

Interplay between cytoskeletal polymerization and the chondrogenic phenotype in chondrocytes passaged in monolayer culture

(2016) Justin Parreno et al.   JOURNAL OF ANATOMY

Chondrocyte Morphology in Stiff and Soft Agarose Gels and the Influence of Fetal Calf Serum

(2016) Asima Karim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration

(2016) S. Ashraf et al.   OSTEOARTHRITIS AND CARTILAGE

Activation of a chondrocyte volume-sensitive Cl − conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model

(2016) K. Kumagai et al.   OSTEOARTHRITIS AND CARTILAGE

Drying of open animal joints in vivo subsequently causes cartilage degeneration

(2016) S. I. Paterson et al.   Bone & Joint Research

Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis

(2016) Christopher J. O’Conor et al.   Scientific Reports

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

(2015) Hyun Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analyzing the effects of mechanical and osmotic loading on glycosaminoglycan synthesis rate in cartilaginous tissues

(2015) Xin Gao et al.   JOURNAL OF BIOMECHANICS

The use of hyperosmotic saline for chondroprotection: implications for orthopaedic surgery and cartilage repair

(2015) N.M. Eltawil et al.   OSTEOARTHRITIS AND CARTILAGE

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes

(2015) Z. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis

(2015) Q. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

An educational review of cartilage repair: precepts & practice – myths & misconceptions – progress & prospects

(2015) E.B. Hunziker et al.   OSTEOARTHRITIS AND CARTILAGE

Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage

(2015) Nicole A. Zelenski et al.   Arthritis & Rheumatology

Chondrocytic cells express the taurine transporter on their plasma membrane and regulate its expression under anisotonic conditions

(2014) Hannu M. Karjalainen et al.   AMINO ACIDS

Hypertonic conditions enhance cartilage formation in scaffold-free primary chondrocyte cultures

(2014) Janne H. Ylärinne et al.   CELL AND TISSUE RESEARCH

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

The structure and function of the pericellular matrix of articular cartilage

(2014) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs

(2013) Markus Rottmar et al.   EXPERIMENTAL CELL RESEARCH

Applied osmotic loading for promoting development of engineered cartilage

(2013) Sonal R. Sampat et al.   JOURNAL OF BIOMECHANICS

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Osmolarity regulates chondrogenic differentiation potential of synovial fluid derived mesenchymal progenitor cells

(2012) Karri L. Bertram et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5

(2012) Marjolein M.J. Caron et al.   BONE

Potassium channels in articular chondrocytes

(2012) Ali Mobasheri et al.   Channels

What constitutes an “animal model of osteoarthritis” – the need for consensus?

(2012) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl- current in rabbit articular chondrocytes

(2011) Kousuke Kumagai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes

(2011) Karsten Schrobback et al.   CELL AND TISSUE RESEARCH

Cell Volume Regulation in Chondrocytes

(2011) Rebecca Lewis et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype

(2011) Kira D. Novakofski et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Roles of cell volume in molecular and cellular biology

(2011) Jean-Marc Dubois et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cartilage cell clusters

(2010) Martin K. Lotz et al.   ARTHRITIS AND RHEUMATISM

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice

(2010) Andrea L. Clark et al.   ARTHRITIS AND RHEUMATISM

Enhanced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Low Oxygen Environment Micropellet Cultures

(2010) Brandon D. Markway et al.   CELL TRANSPLANTATION

A key role for membrane transporter NKCC1 in mediating chondrocyte volume increase in the mammalian growth plate

(2010) Peter G Bush et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Abnormal human chondrocyte morphology is related to increased levels of cell-associated IL-1β and disruption to pericellular collagen type VI

(2010) Dianne H. Murray et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis

(2010) C. Karlsson et al.   OSTEOARTHRITIS AND CARTILAGE

New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options

(2010) Martin K Lotz   ARTHRITIS RESEARCH & THERAPY

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes

(2009) Simon R. Tew et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology

(2009) Emma J. Blain   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Integrity of the cortical actin ring is required for activation of the PI3K/Akt and p38 MAPK signaling pathways in redifferentiation of chondrocytes on chitosan

(2008) E PARK et al.   CELL BIOLOGY INTERNATIONAL

Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters

(2008) S.R. McGlashan et al.   DEVELOPMENTAL DYNAMICS

Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes

(2008) K. Gavenis et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis

(2007) S. Lambrecht et al.   OSTEOARTHRITIS AND CARTILAGE

Control of chondrocyte regulatory volume decrease (RVD) by [Ca2+]i and cell shape

(2007) M.J.P. Kerrigan et al.   OSTEOARTHRITIS AND CARTILAGE