Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis

Ion channel expression and function in normal and osteoarthritic human synovial fluid progenitor cells

(2015) Karri L. Bertram et al.   Channels

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats

(2014) Liana Merrill et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations

(2014) Holly A. Leddy et al.   FASEB JOURNAL

TRPV4 as a therapeutic target for joint diseases

(2014) Amy L. McNulty et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs

(2014) B. Mohanraj et al.   OSTEOARTHRITIS AND CARTILAGE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Cartilage Derived From Murine Induced Pluripotent Stem Cells for Osteoarthritis Drug Screening

(2014) Vincent P. Willard et al.   Arthritis & Rheumatology

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

(2013) B.C.J. van der Eerden et al.   BONE

Chondrocyte channel transcriptomics

(2013) Rebecca Lewis et al.   Channels

Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix

(2013) Tonia L Vincent   CURRENT OPINION IN PHARMACOLOGY

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation

(2013) Sang Sun Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

(2013) Carlene Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity

(2013) R. Sah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

The Impact of Osteoarthritis in the United States

(2012) Louise Murphy et al.   AMERICAN JOURNAL OF NURSING

Increased susceptibility ofTrpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet

(2012) Christopher J O'Conor et al.   ANNALS OF THE RHEUMATIC DISEASES

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Effects of aging on articular cartilage homeostasis

(2012) Martin Lotz et al.   BONE

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Aging processes and the development of osteoarthritis

(2012) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes

(2012) Angus K. T. Wann et al.   FASEB JOURNAL

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass

(2012) Ritsuko Masuyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Histopathology of naturally occurring and surgically induced osteoarthritis in mice

(2012) M.A. McNulty et al.   OSTEOARTHRITIS AND CARTILAGE

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

(2012) M.J. Barter et al.   OSTEOARTHRITIS AND CARTILAGE

What constitutes an “animal model of osteoarthritis” – the need for consensus?

(2012) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Transient Supplementation of Anabolic Growth Factors Rapidly Stimulates Matrix Synthesis in Engineered Cartilage

(2011) Kenneth W. Ng et al.   ANNALS OF BIOMEDICAL ENGINEERING

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

(2011) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Age-dependent alteration of TGF-β signalling in osteoarthritis

(2011) Peter M. van der Kraan et al.   CELL AND TISSUE RESEARCH

TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity

(2011) Tatsuya Kusudo et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

The emerging chondrocyte channelome

(2011) Richard Barrett-Jolley   Frontiers in Physiology

Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice

(2010) Andrea L. Clark et al.   ARTHRITIS AND RHEUMATISM

Genetic Inactivation of Trpml3 Does Not Lead to Hearing and Vestibular Impairment in Mice

(2010) Simone Jörs et al.   PLoS One

An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes

(2009) Yuka Itoh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway

(2009) Mariana Garcia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts

(2008) Ritsuko Masuyama et al.   Cell Metabolism

Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice

(2008) D.R. Seifer et al.   OSTEOARTHRITIS AND CARTILAGE

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreERT2 transgenic mice

(2007) M. Zhu et al.   OSTEOARTHRITIS AND CARTILAGE