Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

(2018) Krista J. Spiller et al.   NATURE NEUROSCIENCE

A critical role of TRPM2 channel in Aβ42 -induced microglial activation and generation of tumor necrosis factor-α

(2017) Sharifah Alawieyah Syed Mortadza et al.   GLIA

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

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Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

(2017) Wenhui Qu et al.   Journal of Neuroinflammation

Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment

(2017) Joshua J. Sturm et al.   JOURNAL OF NEUROSCIENCE

Global hearing health care: new findings and perspectives

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Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus

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The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

(2017) Michael F. Cuccarese et al.   Nature Communications

The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-α and IL-1β to the Pathogenesis of Hearing Loss

(2017) Verónica Fuentes-Santamaría et al.   Frontiers in Neuroanatomy

Microglial Activation in Traumatic Brain Injury

(2017) Cornelius K. Donat et al.   Frontiers in Aging Neuroscience

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

(2016) Duy-Khanh Dang et al.   Journal of Neuroinflammation

Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus

(2016) C. Wu et al.   JOURNAL OF NEUROSCIENCE

The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis

(2016) M. Perny et al.   JOURNAL OF NEUROSCIENCE

Maladaptive plasticity in tinnitus — triggers, mechanisms and treatment

(2016) Susan E. Shore et al.   Nature Reviews Neurology

Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain

(2016) Amanda Sierra et al.   Neural Regeneration Research

The gap-startle paradigm to assess auditory temporal processing: Bridging animal and human research

(2016) Philippe Fournier et al.   PSYCHOPHYSIOLOGY

Stochastic Resonance Controlled Upregulation of Internal Noise after Hearing Loss as a Putative Cause of Tinnitus-Related Neuronal Hyperactivity

(2016) Patrick Krauss et al.   Frontiers in Neuroscience

A Conditioned Behavioral Paradigm for Assessing Onset and Lasting Tinnitus in Rats

(2016) Edward Pace et al.   PLoS One

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

(2015) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats

(2015) Iris B. Hovens et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of acoustic trauma on the auditory system of the rat: The role of microglia

(2015) J.S. Baizer et al.   NEUROSCIENCE

Secreted Factors from Human Vestibular Schwannomas Can Cause Cochlear Damage

(2015) Sonam Dilwali et al.   Scientific Reports

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Delayed Increases in Microvascular Pathology after Experimental Traumatic Brain Injury Are Associated with Prolonged Inflammation, Blood–Brain Barrier Disruption, and Progressive White Matter Damage

(2014) Olena Y. Glushakova et al.   JOURNAL OF NEUROTRAUMA

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date

(2014) Antonino Tuttolomondo et al.   Drug Design Development and Therapy

Altered Neuronal Response During Rapid Auditory Processing and Its Relation to Phonological Processing in Prereading Children at Familial Risk for Dyslexia

(2013) Nora M. Raschle et al.   CEREBRAL CORTEX

Impaired Development and Competitive Refinement of the Cortical Frequency Map in Tumor Necrosis Factor- -Deficient Mice

(2013) S. Yang et al.   CEREBRAL CORTEX

TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo

(2013) Warangkana Arpornchayanon et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Tumor Necrosis Factor-alpha-mutant Mice Exhibit High Frequency Hearing Loss

(2013) Naoki Oishi et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

TNF-  Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors

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The contribution of TNF-α in the amygdala to anxiety in mice with persistent inflammatory pain

(2013) Jun Chen et al.   NEUROSCIENCE LETTERS

Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus

(2013) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap detection deficits in humans with tinnitus as assessed with the acoustic startle paradigm: Does tinnitus fill in the gap?

(2012) Philippe Fournier et al.   HEARING RESEARCH

Long-term, but not transient, threshold shifts alter the morphology and increase the excitability of cortical pyramidal neurons

(2012) Sungchil Yang et al.   JOURNAL OF NEUROPHYSIOLOGY

Diminished Cortical Inhibition in an Aging Mouse Model of Chronic Tinnitus

(2012) D. A. Llano et al.   JOURNAL OF NEUROSCIENCE

Tracking the Expression of Excitatory and Inhibitory Neurotransmission-Related Proteins and Neuroplasticity Markers after Noise Induced Hearing Loss

(2012) Cherylea J. Browne et al.   PLoS One

Age-related changes in auditory temporal processing in the rat

(2011) Daniel Šuta et al.   EXPERIMENTAL GERONTOLOGY

Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons

(2011) Ping He et al.   FASEB JOURNAL

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Tinnitus and its risk factors in the Beaver Dam Offspring Study

(2011) David M. Nondahl et al.   INTERNATIONAL JOURNAL OF AUDIOLOGY

Reversing pathological neural activity using targeted plasticity

(2011) Navzer D. Engineer et al.   NATURE

TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus

(2011) Mirko Santello et al.   NEURON

Homeostatic plasticity drives tinnitus perception in an animal model

(2011) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPA-receptor trafficking and injury-induced cell death

(2010) Michael S. Beattie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ringing Ears: The Neuroscience of Tinnitus

(2010) L. E. Roberts et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor-  Signaling Maintains the Ability of Cortical Synapses to Express Synaptic Scaling

(2010) C. C. Steinmetz et al.   JOURNAL OF NEUROSCIENCE

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

(2010) Jenna M. Ziebell et al.   Neurotherapeutics

Emerging pharmacotherapy of tinnitus

(2009) Berthold Langguth et al.   EXPERT OPINION ON EMERGING DRUGS

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Rapid Tumor Necrosis Factor  -Induced Exocytosis of Glutamate Receptor 2-Lacking AMPA Receptors to Extrasynaptic Plasma Membrane Potentiates Excitotoxicity

(2008) D. Leonoudakis et al.   JOURNAL OF NEUROSCIENCE

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Dexamethasone protects organ of corti explants against tumor necrosis factor-alpha–induced loss of auditory hair cells and alters the expression levels of apoptosis-related genes

(2008) C.T. Dinh et al.   NEUROSCIENCE

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents

(2007) R. Holly Fitch et al.   BRAIN RESEARCH BULLETIN

Adenosine in the central nervous system: release mechanisms and extracellular concentrations

(2003) Serena Latini et al.   JOURNAL OF NEUROCHEMISTRY