Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood–Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats

(2018) Olena Y. Glushakova et al.   JOURNAL OF NEUROTRAUMA

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer

(2018) Eugene W. Gerner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC3A2 is a novel endoplasmic reticulum stress-related signaling protein that regulates the unfolded protein response and apoptosis

(2018) Chunlei Liu et al.   PLoS One

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Subjective memory complaints in preclinical autosomal dominant Alzheimer disease

(2017) Daniel J. Norton et al.   NEUROLOGY

Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden

(2017) Rachel F. Buckley et al.   JAMA Neurology

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

(2017) Richard Rubenstein et al.   JAMA Neurology

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

Co-expression of truncated and full-length tau induces severe neurotoxicity

(2016) S Ozcelik et al.   MOLECULAR PSYCHIATRY

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

(2016) YoungDoo Kim et al.   NEUROBIOLOGY OF DISEASE

Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model

(2016) Stephanie L. Ciarlone et al.   NEUROBIOLOGY OF DISEASE

Targets of polyamine dysregulation in major depression and suicide: Activity-dependent feedback, excitability, and neurotransmission

(2016) Agenor Limon et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modulation of learning and memory by natural polyamines

(2016) Gustavo Petri Guerra et al.   PHARMACOLOGICAL RESEARCH

Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

(2016) Cecilia A. Brunello et al.   Scientific Reports

The relationship of cognition, cognitive reserve, and in vivo tau and amyloid burden

(2015) Dorene M. Rentz et al.   Alzheimers & Dementia

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

Reelin supplementation recovers synaptic plasticity and cognitive deficits in a mouse model for Angelman syndrome

(2015) Whitney R. Hethorn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement

(2015) Sarah N. Fontaine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell

(2015) Leonor Miller-Fleming et al.   JOURNAL OF MOLECULAR BIOLOGY

Spermine reverses lipopolysaccharide-induced memory deficit in mice

(2015) Pâmella Frühauf et al.   Journal of Neuroinflammation

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

(2015) J. B. Hunt et al.   JOURNAL OF NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

(2015) Yingjun Zhao et al.   NEURON

Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease

(2015) Stewart F. Graham et al.   PLoS One

TAU PET USING F18-T807: INITIAL EXPERIENCE IN NORMAL ELDERLY AND AD DEMENTIA

(2014) Keith A. Johnson et al.   Alzheimers & Dementia

Spermidine improves fear memory persistence

(2014) Cristiane Signor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tau-Mediated NMDA Receptor Impairment Underlies Dysfunction of a Selectively Vulnerable Network in a Mouse Model of Frontotemporal Dementia

(2014) Brian A. Warmus et al.   JOURNAL OF NEUROSCIENCE

The molecular bases of the suicidal brain

(2014) Gustavo Turecki   NATURE REVIEWS NEUROSCIENCE

Altered arginine metabolism in Alzheimer's disease brains

(2014) Ping Liu et al.   NEUROBIOLOGY OF AGING

Snyder-Robinson syndrome: A novel nonsense mutation in spermine synthase and expansion of the phenotype

(2013) Angela Peron et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Spermidine-triggered autophagy ameliorates memory during aging

(2013) Stephan J Sigrist et al.   Autophagy

Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases

(2013) Myung Hee Park et al.   Biomolecules & Therapeutics

Aliphatic polyamines in physiology and diseases

(2013) D. Ramani et al.   CLINICAL NUTRITION

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers

(2013) Juan Pablo Lopez et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dab1 Is Required for Synaptic Plasticity and Associative Learning

(2013) J. Trotter et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Polyamines and suicide risk

(2013) G Turecki   MOLECULAR PSYCHIATRY

Discovery and validation of blood biomarkers for suicidality

(2013) H Le-Niculescu et al.   MOLECULAR PSYCHIATRY

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy

(2013) Kevin R. Nash et al.   NEUROBIOLOGY OF AGING

Polyaminergic agents modulate the reconsolidation of conditioned fear

(2013) Daniela Aymone Ribeiro et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice

(2013) Nikisha Carty et al.   PLoS One

Metabolic profiling of Alzheimer's disease brains

(2013) Koichi Inoue et al.   Scientific Reports

Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A

(2012) Gustavo P. Guerra et al.   JOURNAL OF NEUROCHEMISTRY

Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse

(2012) Justin T Rogers et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Traumatic brain injury: A risk factor for Alzheimer's disease

(2012) Thamil Mani Sivanandam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

(2012) Vanessa Plouffe et al.   PLoS One

Mild traumatic brain injury: a risk factor for neurodegeneration

(2012) Brandon E Gavett et al.   Alzheimers Research & Therapy

Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide

(2011) Laura M. Fiori et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in Suicide

(2011) Laura M. Fiori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Increased Interstitial White Matter Neuron Density in the Dorsolateral Prefrontal Cortex of People with Schizophrenia

(2010) Yang Yang et al.   BIOLOGICAL PSYCHIATRY

Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

(2010) Man-Jeong Paik et al.   CLINICA CHIMICA ACTA

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers

(2010) Laura M. Fiori et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain

(2010) Nikisha Carty et al.   JOURNAL OF NEUROSCIENCE METHODS

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Evidence of Altered Polyamine Concentrations in Cerebral Cortex of Suicide Completers

(2010) Gary Gang Chen et al.   NEUROPSYCHOPHARMACOLOGY

Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide

(2010) Laura M. Fiori et al.   PLoS One

Polyamine pathway contributes to the pathogenesis of Parkinson disease

(2010) N. M. Lewandowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of Spermidine/Spermine N1-Acetyltransferase Promoter Variants in Suicide Completers

(2009) Laura M. Fiori et al.   BIOLOGICAL PSYCHIATRY

Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder

(2009) Caroline M. Connor et al.   BIOLOGICAL PSYCHIATRY

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Polyamine Catabolism Is Enhanced after Traumatic Brain Injury

(2009) Kamyar Zahedi et al.   JOURNAL OF NEUROTRAUMA

Genetic and epigenetic analysis of SSAT gene dysregulation in suicidal behavior

(2008) Michel Guipponi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS