Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

(2018) Purva Singh et al.   Annals of the New York Academy of Sciences

Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair

(2018) Ruzanna Shkhyan et al.   ANNALS OF THE RHEUMATIC DISEASES

Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of IkappaBzeta

(2018) Moon-Chang Choi et al.   Arthritis & Rheumatology

Cushioning the cartilage: a canonical Wnt restricting matter

(2017) Silvia Monteagudo et al.   Nature Reviews Rheumatology

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

(2016) Yasuhito Yahara et al.   Nature Communications

The inhibition of EZH2 ameliorates osteoarthritis development through the Wnt/β-catenin pathway

(2016) Linwei Chen et al.   Scientific Reports

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

Strategies for the prevention of knee osteoarthritis

(2015) Ewa M. Roos et al.   Nature Reviews Rheumatology

RECENT RESEARCH ON THE GROWTH PLATE: Recent insights into the regulation of the growth plate

(2014) J. C. Lui et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The individual and socioeconomic impact of osteoarthritis

(2014) David J. Hunter et al.   Nature Reviews Rheumatology

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

(2013) Eleonora Olivotto et al.   PLoS One

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

(2013) Y. Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Inhibitor of NF- B Kinases   and   Are Both Essential for High Mobility Group Box 1-Mediated Chemotaxis

(2010) M. Penzo et al.   JOURNAL OF IMMUNOLOGY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage

(2009) Stephen P. Henry et al.   GENESIS

IKK  is a critical coregulator of a Smad4-independent TGF -Smad2/3 signaling pathway that controls keratinocyte differentiation

(2008) P. Descargues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA