RECENT RESEARCH ON THE GROWTH PLATE: Recent insights into the regulation of the growth plate

Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression

(2013) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Activating Mutation in the Kinase Homology Domain of the Natriuretic Peptide Receptor-2 Causes Extremely Tall Stature Without Skeletal Deformities

(2013) Sabine E. Hannema et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Gene as a Cause of Short Stature in Patients Initially Classified as Idiopathic Short Stature

(2013) Gabriela A. Vasques et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

(2013) Masaki Matsushita et al.   PLoS One

Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice

(2013) S. Garcia et al.   Science Translational Medicine

Evaluation of the Therapeutic Potential of a CNP Analog in a Fgfr3 Mouse Model Recapitulating Achondroplasia

(2012) Florence Lorget et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

(2012) Y. C. Woo et al.   CLINICAL ENDOCRINOLOGY

Role of Fibroblast Growth Factor 21 (FGF21) in Undernutrition-Related Attenuation of Growth in Mice

(2012) Rita Ann Kubicky et al.   ENDOCRINOLOGY

Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height

(2012) Julian C. Lui et al.   HUMAN MOLECULAR GENETICS

Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate

(2012) Shufang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis

(2012) Chloe Pass et al.   JOURNAL OF BONE AND MINERAL RESEARCH

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

(2012) Kohji Miura et al.   PLoS One

Nosology and classification of genetic skeletal disorders: 2010 revision

(2011) Matthew L. Warman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Sixteen years and counting: The current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

(2011) Silvie Foldynova-Trantirkova et al.   HUMAN MUTATION

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

Severe Short Stature Caused by Novel Compound Heterozygous Mutations of the Insulin-Like Growth Factor 1 Receptor (IGF1R)

(2011) Peng Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Organization of the Indian hedgehog – parathyroid hormone-related protein system in the postnatal growth plate

(2011) Michael Chau et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Spatial and temporal regulation of gene expression in the mammalian growth plate

(2010) Julian C.K. Lui et al.   BONE

The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins

(2010) S F Ahmed et al.   JOURNAL OF ENDOCRINOLOGY

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Regulation of Gene Expression by PI3K in Mouse Growth Plate Chondrocytes

(2010) Veronica Ulici et al.   PLoS One

Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life

(2010) T. Hirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

(2009) Jan Christiansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Epiphyseal Fusion in the Human Growth Plate Does not Involve Classical Apoptosis

(2009) Joyce Emons et al.   PEDIATRIC RESEARCH

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

(2008) T. Matsushita et al.   HUMAN MOLECULAR GENETICS

STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

(2008) P. Krejci et al.   JOURNAL OF CELL SCIENCE

Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice

(2008) V.E. MacRae et al.   JOURNAL OF CELLULAR PHYSIOLOGY

βKlotho Is Required for Fibroblast Growth Factor (FGF) 21 Signaling through FGF Receptor (FGFR) 1c and FGFR3c

(2008) Masashi Suzuki et al.   MOLECULAR ENDOCRINOLOGY

Genome-wide association analysis identifies 20 loci that influence adult height

(2008) Michael N Weedon et al.   NATURE GENETICS