Article
Biotechnology & Applied Microbiology
Yan Chen, Zewen Liu, Zhengqing Hu, Xiuyuan Feng, Li Zuo
Summary: The study revealed that Trim27 plays an important role in pressure overload-induced cardiac hypertrophy and promotes cardiac hypertrophy by activating the PTEN/Akt/GSK3 beta/mTOR signaling pathway.
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Summary: This study utilized computational models and software tools to analyze the mechanisms regulating the switch between permanent and transient cartilage, identifying potential therapeutic opportunities. Combinatorial treatments were tested and validated experimentally, showing both positive and negative effects on cartilage formation and growth, providing insights for interventions in normal cartilage development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jaime Balderas-Villalobos, J. M. Lourdes Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Janee Hayles, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit
Summary: Frequent premature ventricular contractions (PVCs) in a large animal model of PVC-induced cardiomyopathy (PVC-CM) resulted in eccentric cardiac hypertrophy and reduced ejection fraction. The molecular mechanisms and markers of this hypertrophic remodeling were explored. Pathological hypertrophy markers were unaltered, while prohypertrophic and antiapoptotic pathways were activated in the PVC-CM group.
Article
Health Care Sciences & Services
Richard J. Roberts, Logan Hallee, Chi Keung Lam
Summary: Hsp90 is a key molecular chaperone that interacts with numerous disease pathways in cells, making it a potential therapeutic target. While small-molecule inhibition of Hsp90 activity may have cardiac toxicity, targeting Hsp90 through modulation of post-translational modifications (PTMs) could be a more attractive therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lu Gao, Sen Guo, Rui Long, Lili Xiao, Rui Yao, Xiaolin Zheng, Yanzhou Zhang, Xiaofang Wang
Summary: LAPTM5 is involved in pathological cardiac hypertrophy by binding to Rac1 and inhibiting the MEK-ERK1/2 signaling pathway, ultimately regulating the development of hypertrophy. Targeting LAPTM5 may hold great therapeutic potential in treating pathological cardiac hypertrophy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Wei Dong, Xiaoxiao Xu, Yao Luo, Chang Yang, Ying He, Xiaofei Dong, Jiawei Wang
Summary: The study demonstrated that PTX3 can induce osteogenic differentiation in an inflammatory environment by activating the HA/CD44/FAK/AKT positive feedback loop, and promote bone regeneration after periodontitis.
Article
Pharmacology & Pharmacy
Chen Chen, Xiyu Zhang, Cuiting Zheng, Zhenqiang Gao, Xi Jiang, Yunfei Bai, Yan Meng
Summary: A thorough understanding of the pathological process of hypertension-induced cardiac remodelling can help prevent and treat heart failure. In this study, it was found that SASP exacerbates AngII-induced cardiac remodelling through the activation of the Akt signaling pathway, independent of its anti-inflammatory property.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michaela Adamcova, Ippei Kawano, Fedor Simko
Summary: The renin-angiotensin system (RAS) plays a central role in cardiovascular remodeling, with microRNAs emerging as a novel approach to studying RAS-induced cardiac remodeling. Current research on microRNAs is still in its early stages, but holds potential for future therapeutic strategies in treating cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Sara Salucci, Alberto Bavelloni, Anna Bartoletti Stella, Francesco Fabbri, Ivan Vannini, Manuela Piazzi, Karyna Volkava, Katia Scotlandi, Giovanni Martinelli, Irene Faenza, William Blalock
Summary: Approximately 7% of childhood cancers and 1% of adult cancers are soft tissue sarcomas, with rhabdomyosarcoma being the most common subtype. Despite current therapeutic protocols, survival rates for RMS have not improved significantly in the past decade. Curcumin, derived from the Curcuma longa plant, has low toxicity and has shown anti-tumorigenic effects in vitro. This study evaluated curcumin's activity in RMS cell lines and identified the major pathways affected by curcumin's anti-tumorigenic effects. Curcumin treatment resulted in cell cycle arrest, inhibited migration and colony formation, and induced apoptosis. Proteome profiler analysis revealed that curcumin primarily influenced signaling through AKT-mTOR, STAT, AMPK, and p53 pathways in a subtype-specific manner. Combinational therapeutic targeting of these pathways may be the best option for RMS treatment.
Article
Biochemistry & Molecular Biology
Synne S. Hansen, Tina M. Pedersen, Julie Marin, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum, Anne D. Hafstad
Summary: Low doses of AngII can transiently impair cardiac efficiency, and NOX2 overexpression exacerbates the cardiac dysfunction and myocardial metabolic remodeling induced by AngII.
Article
Multidisciplinary Sciences
Kirsten T. Nijholt, Pablo I. Sanchez-Aguilera, Harmen G. Booij, Silke U. Oberdorf-Maass, Martin M. Dokter, Anouk H. G. Wolters, Ben N. G. Giepmans, Wiek H. van Gilst, Joan H. Brown, Rudolf A. de Boer, Herman H. W. Sillje, B. Daan Westenbrink
Summary: This study aimed to determine if AKIP1 promotes physiological cardiomyocyte hypertrophy in vivo. The results showed that AKIP1-TG mice exhibited increased exercise-induced cardiac hypertrophy compared to wild type mice. AKIP1 may serve as a regulator of cardiomyocyte elongation and physiological cardiac remodelling.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Marta Vigil-Garcia, Charlotte J. Demkes, Joep E. C. Eding, Danielle Versteeg, Hesther de Ruiter, Ilaria Perini, Lieneke Kooijman, Monika M. Gladka, Folkert W. Asselbergs, Aryan Vink, Magdalena Harakalova, Alexander Bossu, Toon A. B. van Veen, Cornelis J. Boogerd, Eva van Rooij
Summary: This study identified novel genes induced during pathological hypertrophy using cardiomyocyte-specific transcriptomic analysis, which are relevant for human heart failure, indicating potential targets for therapeutic interventions.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Article
Plant Sciences
Jia Gu, Ming Qiu, Yan Lu, Yue Ji, Zhihong Qian, Wei Sun
Summary: Piperlongumine (PLG) was found to significantly inhibit cardiac hypertrophy and fibrosis, attenuating cardiomyocyte hypertrophy by reducing the phosphorylation of Akt and preserving the level of FoxO1, and decreasing the expression of profibrotic proteins in cardiac fibroblasts by reducing KLF4 expression. These findings demonstrate the cardioprotective effects of PLG and its potential for developing novel medications for pathological cardiac hypertrophy and heart failure.
Article
Cardiac & Cardiovascular Systems
Xiaohong Liu, Liuqing Yang, Dongmin Kwak, Lei Hou, Ruru Shang, Carolyn Meyer, Angela Panoskaltsis-Mortari, Xin Xu, Edward Kenneth Weir, Yingjie Chen
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2019)
Article
Physiology
Xiaoguang Liu, Lifang Zhen, Yongzhan Zhou, Yingjie Chen, Peijie Chen, Weihua Xiao
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Thenappan Thenappan, Alexander Khoruts, Yingjie Chen, E. Kenneth Weir
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Haipeng Guo, Dachun Xu, Marcos Kuroki, Zhongbing Lu, Xin Xu, Aron Geurts, John W. Osborn, Yingjie Chen
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, General & Internal
E. Kenneth Weir, Thenappan Thenappan, Maneesh Bhargava, Yingjie Chen
Article
Cardiac & Cardiovascular Systems
Linlin Shang, Wenhui Yue, Dongzhi Wang, Xinyu Weng, Michael E. Hall, Yawei Xu, Mingxiao Hou, Yingjie Chen
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Medicine, Research & Experimental
Jian Shou, Xinjuan Shi, Xiaoguang Liu, Yingjie Chen, Peijie Chen, Weihua Xiao
Summary: The research demonstrates that PD-1 can promote contused skeletal muscle regeneration by regulating Treg cell generation and macrophage polarization, providing further insight into the relationship between the immune system and injured skeletal muscle regeneration.
LABORATORY INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mengqiu Ma, Yanhua Xu, Yang Su, Sang-Bing Ong, Xingdong Hu, Min Chai, Maojun Zhao, Hong Li, Xiaojuan Fan, Yingjie Chen, Dachun Xu, Xiaojiang Xu
Summary: The study found that ACE2 expression is significantly increased in both cardiomyocytes and non-cardiomyocytes in failing hearts. Brain natriuretic peptide and atrial natriuretic peptide are also significantly up-regulated in ACE2+ cardiomyocytes, consistent with other studies. Genes related to virus entry, replication, and suppression of interferon-gamma signaling are up-regulated in failing cardiomyocytes, with a higher increase in ACE2+ cardiomyocytes, indicating their vulnerability to virus infection.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jong Han Lee, Ligen Lin, Xiangcang Ye, Christian Wolfrum, Yingjie Chen, Shaodong Guo, Yuxiang Sun
Summary: The study reveals that GHS-R has a cell-autonomous effect in brown adipocytes and regulates BAT thermogenic activity in a temperature- and metabolic state-dependent manner. The thermogenic effect of GHS-R in BAT is more pronounced in a cold environment and differentially variable based on metabolic state. Overall, GHS-R in BAT acts as a metabolic thermostat that differentially regulates thermogenesis in response to different metabolic and thermal stimuli.
Article
Immunology
Xiaoguang Liu, Xinyu Weng, Weihua Xiao, Xin Xu, Yingjie Chen, Peijie Chen
Summary: The study revealed that PD-1 plays an important role in hindlimb ischemia-induced inflammation and angiogenesis in mice. Inhibition of PD-1 significantly attenuated hindlimb blood perfusion, angiogenesis, and exercise capacity in the mice after femoral artery ligation. The mechanism involves exacerbation of muscle oxidative stress, leukocyte infiltration, IFN-gamma production, and TNF-alpha activation in PD-1 knockout mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell & Tissue Engineering
Junling Gao, Juntao Yuan, Qun Liu, Yuanli Wang, Huiwen Wang, Yingjie Chen, Wenjun Ding, Guangju Ji, Zhongbing Lu
Summary: The research found that ADSCs can protect against the adverse health effects of PM2.5 exposure by attenuating pulmonary inflammation and cell death. This suggests that ADSC transplantation may be a potential therapeutic approach for severe air pollution-associated diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Lihong Pan, Peiyuan Bai, Xinyu Weng, Jin Liu, Yingjie Chen, Siqin Chen, Xiurui Ma, Kai Hu, Aijun Sun, Junbo Ge
Summary: The role of legumain (LGMN) in thoracic aortic dissection (TAD) development and vascular smooth muscle cell (VSMC) differentiation was investigated. Elevated LGMN levels were observed in aorta and sera from TAD patients and in BAPN-induced TAD model mice. LGMN was found to regulate VSMC phenotype transformation and its inhibition ameliorated TAD progression.
Article
Pharmacology & Pharmacy
Gerald Woelkart, Heike Stessel, Erin Fassett, Eva Teschl, Katrin Friedl, Modesta Trummer, Astrid Schrammel, Alexander Kollau, Bernd Mayer, John Fassett
Summary: Pharmacological inhibition of adenosine kinase can induce sustained cardioprotection by increasing adenosine signaling. This study identified a novel effect of the ADK inhibitor, ABT-702, on cardiac ADK protein longevity and demonstrated its impact on sustained adenosinergic cardioprotection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Wang, Rifeng Gao, Tingting Wu, Jinyan Zhang, Xiaolei Sun, Fan Fan, Cong Wang, Sanli Qian, Bingyu Li, Yunzeng Zou, Yuqing Huo, John Fassett, Yingjie Chen, Junbo Ge, Aijun Sun
Summary: This study demonstrates that cardiomyocyte ADK deletion improves myocardial I/R injury through epigenetic upregulation of IGF-1 expression.
Meeting Abstract
Cardiac & Cardiovascular Systems
Roman Rodionov, Natalia Jarzebska, Dmitri Burdin, Silke Brilloff, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Henning Morawietz, Karl F. Hilgers, Nada Cordasic, Johannes Jacobi, Renke Maas, Yingjie Chen, Stefanie Bode-Boger, Bernd Hohenstein, Norbert Weiss