Article
Oncology
Jing Li, Yinmou Li, Hong Cheng
Summary: This study indicates that the silencing of circ-RPPH1 can suppress the malignant phenotypes and glycolysis of breast cancer cells through the miR-328-3p/HMGA2 axis, thereby impeding the progression of breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Hangyu Zhang, Changgang Liu, Xinbo Wang, Yongfang Wang, Jie Zheng
Summary: SCARA5 expression is downregulated in gastric cancer, associated with promoter methylation, aggressive clinicopathological characteristics, and poor prognosis. Overexpression of SCARA5 inhibits the growth and migration of GC cells, potentially serving as a biomarker for diagnosis and therapeutic target.
Article
Cell Biology
Lifang Luo, Wenjing Sun, Weijian Zhu, Shuhan Li, Wenqi Zhang, Xiaohui Xu, Daoquan Fang, Tan Hooi Min Grahn, Lei Jiang, Yihu Zheng
Summary: The study revealed that BCAT1 regulates autophagy through the mTOR signaling pathway, decreasing the sensitivity of cancer cells to cisplatin, while branched-chain amino acids or leucine can reverse this process, enhancing the efficacy of cisplatin.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Nan Li, Xinyue Wang, Jie Sun, Ying Liu, Anna Han, Zhenhua Lin, Yang Yang
Summary: This study demonstrates that Tiam1 interacts with the glycolytic enzyme PFKL to promote the evolution of breast cancer in a PFKL-dependent manner. The miR-21-5p/Tiam1/PFKL signaling pathway could be explored as a potential target for new anti-breast cancer therapeutic strategies.
Article
Cell Biology
Xuehui Wang, Hongming Song, Lin Fang, Tianqi Wu
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)
Review
Gastroenterology & Hepatology
Samantha B. Kemp, Marina Pasca di Magliano, Howard C. Crawford
Summary: Pancreatic ductal adenocarcinoma (PDA) is a nearly universally lethal malignancy characterized by extensive infiltration of immunosuppressive myeloid cells, inhibiting normal immune functions and promoting carcinogenesis. Current immune checkpoint therapy has not been effective in PDA, highlighting the importance of understanding the mechanisms underlying immune suppression in this type of cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qinggang Li, Xiaonan Liu, Jian Mao, Shimin Liu, Baosen Hou, Kaiyan Li, Dandong Fang
Summary: This study reveals that the decreased expression of RRAGB in GBM is associated with poor prognosis and tumor characteristics. RRAGB up-regulation suppresses the proliferation, migration, and invasion of GBM cells through the PI3K/AKT pathway. Animal experiments demonstrate that RRAGB over-expression inhibits tumor growth and improves overall survival rates.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Xiaosheng Wu, Hao Wang, Danping Zhu, Yixia Chai, Jing Wang, Weiyu Dai, Yizhi Xiao, Weimei Tang, Jiaying Li, Linjie Hong, Miaomiao Pei, Jieming Zhang, Zhizhao Lin, Jide Wang, Aimin Li, Side Liu
Summary: This study reveals the mechanism of how deubiquitinating enzyme USP3 promotes tumor progression and metastasis in gastric cancer. The downstream targets of USP3, COL9A3 and COL6A5, are identified using isobaric tags technique. The results show that USP3 interacts with and stabilizes COL9A3 and COL6A5 through deubiquitination, playing a crucial role in the oncogenic activity of USP3 both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee, Semi Kim
Summary: TMEM52B has been identified as a novel gene expressed widely in normal human tissues. Suppression of TMEM52B in colon cancer cells leads to enhanced epithelial-mesenchymal transition (EMT), invasion, and survival, potentially through multiple signaling pathways. Clinical data suggest that high TMEM52B expression is associated with increased patient survival in various types of cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Hua Huang, Ruining Pan, Yue Zhao, Huan Li, Huiyu Zhu, Sijia Wang, Aamir Ali Khan, Juan Wang, Xinhui Liu
Summary: This study reveals the crucial roles of L3MBTL2 and CGA in tumor development. L3MBTL2 represses CGA through an H2AK119ub1-dependent mechanism, and the individual tumor suppressor role of CGA in PDAC is partly dependent on its own glycosylation.
Article
Cell Biology
Tianyi Wu, Guangke Wang, Xianting Zeng, Zhanwei Sun, Shichao Li, Weiwei Wang, Boyu Yu
Summary: The study demonstrates that hsa_circ_0006232 promotes proliferation, migration, and invasion of LSCC cells, and accelerates tumor growth through FUS-mediated EZH2 stabilization. Therefore, hsa_circ_0006232 may be a novel therapeutic target in LSCC treatment.
Article
Oncology
Yandong Huang, Qinyang Bai, Zhanlong Wang, Hongbo Yu, Yanru Li, Hao Lu, Huimin Kang, Xuewei Shi, Kai Feng
Summary: This study revealed that circ_0052184 promotes the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis, providing an explanation for the malignant progression of colorectal cancer at the molecular level.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Oncology
Zhigang Zhao, Shankun Zhao, Lianmin Luo, Qian Xiang, Zhiguo Zhu, Jiamin Wang, Yangzhou Liu, Jintai Luo
Summary: The study demonstrates a tumor-suppressive role of miR-199b-5p in invasion and metastasis of PCa by inhibiting DDR1 expression and EMT, leading to poor prognosis in patients. Additionally, the miR-199b-5p-DDR1-ERK signaling axis represents a novel mechanism for regulating EMT in PCa metastases.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Da Kyung Choi, Jung Sun Min, Inho Kang, Jin Chul Kim, Semi Kim, Jeong Keun Ahn
Article
Oncology
Dongjoon Ko, Semi Kim
Article
Biochemistry & Molecular Biology
Amir Abbas Mokhtarieh, Jieun Lee, Semi Kim, Myung Kyu Lee
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Cell Biology
Jae Woo Jung, Stephani Joy Y. Macalino, Minghua Cui, Ji Eon Kim, Hye-Jin Kim, Dae-Geun Song, Seo Hee Nam, Semi Kim, Sun Choi, Jung Weon Lee
Article
Multidisciplinary Sciences
Jee Soo Choi, Hongmarn Park, Wonkyong Kim, Younghoon Lee
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Wonkyong Kim, Younghoon Lee
Article
Oncology
Jihye Ryu, Eunmi Kim, Min-Kyung Kang, Dae-Geun Song, Eun-Ae Shin, Haesong Lee, Jae Woo Jung, Seo Hee Nam, Ji Eon Kim, Hye-Jin Kim, Taekwon Son, Semi Kim, Hwi Young Kim, Jung Weon Lee
Summary: The study revealed the crucial role of TM4SF5 in the progression of nonalcoholic steatohepatitis (NASH), including inducing lipid accumulation, inflammatory responses, and fibrosis in liver tissue. TM4SF5, along with signaling pathways involving SIRT1, SREBPs, and SOCS/STAT3, promoted the development of NASH.
JOURNAL OF PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Atanu Naskar, Sohee Lee, Yunhee Lee, Semi Kim, Kwang-sun Kim
Article
Biochemistry & Molecular Biology
Heegwon Shin, Yejin Jang, Sangmi Jun, Younghoon Lee, Meehyein Kim
Summary: This study investigates the impact of the promoter structure of influenza A virus genomic RNA on virus replication, revealing that the first segment-specific base pair plays a crucial role in regulating cRNA promoter activity.
Article
Oncology
Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee, Semi Kim
Summary: TMEM52B has been identified as a novel gene expressed widely in normal human tissues. Suppression of TMEM52B in colon cancer cells leads to enhanced epithelial-mesenchymal transition (EMT), invasion, and survival, potentially through multiple signaling pathways. Clinical data suggest that high TMEM52B expression is associated with increased patient survival in various types of cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hyejin Cho, Atanu Naskar, Sohee Lee, Semi Kim, Kwang-Sun Kim
Summary: A nickel-doped zinc oxide and black phosphorus nanocomposite displayed a strong synergistic effect with polymyxin B against polymyxin-resistant E. coli, neutralizing the charge on the bacterial surface and facilitating the incorporation of polymyxin B. The combination was shown to be biocompatible and has the potential to revive polymyxins as effective antibiotics against resistant Gram-negative bacterial infections.
Article
Oncology
Yunhee Lee, Junghwa Yoon, Dongjoon Ko, Minyeong Yu, Soojin Lee, Semi Kim
Summary: TMPRSS4 promotes cancer stem cell features in prostate cancer by upregulating the stem cell factor SOX2 through the EMT-inducing transcription factors SLUG and TWIST1. This novel mechanism may play a crucial role in tumor progression control.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Heegwon Shin, Jungmin Lee, Youngmi Kim, Seonghui Jang, Meehyein Kim, Younghoon Lee
MOLECULES AND CELLS
(2019)