Review
Biochemistry & Molecular Biology
Rami S. Najjar, Arielle M. Schwartz, Brett J. Wong, Puja K. Mehta, Rafaela G. Feresin
Summary: Ischemia with no obstructive coronary artery disease (INOCA) is a common diagnosis with a higher prevalence in women, associated with major adverse cardiovascular outcomes and angina. Coronary microvascular dysfunction (CMD) is a major feature, driven by inflammatory and oxidative stress signaling, and treatment focuses on addressing cardiovascular risk factors. Potential treatment options include berry-derived polyphenols to modulate these pathways, with future clinical trials needed to investigate their effectiveness in INOCA patients with CMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Zaixiao Tao, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zhongguo Fan, Xi Chen, Rong Huang, Xinxin Li, Genshan Ma
Summary: This cross-sectional study aimed to investigate the association between dietary intake of anthocyanidins and heart failure. The results showed a significant negative association between high anthocyanidins intake and the prevalence of heart failure, and this association was stable among different subgroups.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Sule Kocabas, Nevin Sanlier
Summary: Cardiovascular diseases (CVDs) are a growing threat to human health. This article focuses on the potential positive effects of berries on CVDs. Berries contain polyphenols that have beneficial effects on the vascular system, such as reducing oxidative stress and inflammation, improving endothelial function, and lowering blood pressure. Analyzing the bioactivity and mechanisms of berry metabolites is essential to understanding how they can improve vascular function.
Article
Nutrition & Dietetics
Qin Gao, Chunrong Zhong, Xuezhen Zhou, Renjuan Chen, Ting Xiong, Miao Hong, Qian Li, Man Kong, Guoping Xiong, Weizhen Han, Guoqiang Sun, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: Higher dietary intake of total polyphenols and flavonoids, as well as intake from fruits, was associated with lower risk of GDM.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Roland Gal, Robert Halmosi, Ferenc Gallyas Jr, Michael Tschida, Pornthira Mutirangura, Kalman Toth, Tamas Alexy, Laszlo Czopf
Summary: Cardiovascular diseases (CVDs) are a major cause of illness and death worldwide. Unhealthy dietary habits have been shown to contribute to the development of CVDs. Natural polyphenols, found in fruits, vegetables, and red wine, play a clear role in improving cardiovascular health. This review summarizes the results of pre-clinical and clinical trials on important natural polyphenols such as resveratrol and flavonoids, their sources and biosynthesis, and their regulatory effect on signal transduction pathways. Additionally, scientific evidence is provided regarding the cardiovascular benefits of moderate, long-term red wine consumption.
Article
Nutrition & Dietetics
Joaquin Garcia-Cordero, Alicia Pino, Constanza Cuevas, Veronica Puertas-Martin, Ricardo San Roman, Sonia de Pascual-Teresa
Summary: The elderly population has been increasing, leading to a rise in age-related diseases. To address this global health issue, researchers conducted a study on the effects of cocoa flavanols and red berry anthocyanins on cognitive performance in older adults. The intervention resulted in improved executive function and reduced time needed to complete a cognitive test.
Review
Environmental Sciences
Yunshu Liao, Qinghua Meng
Summary: Cancer therapy-induced heart injury is a concern for cancer patients, but polyphenols and nanoparticles loaded with polyphenols show promise in protecting the heart from damage. Polyphenols can reduce oxidative stress and cardiomyocyte damage, thus preserving cardiac function.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Samuele Laudani, Justyna Godos, Federica Martina Di Domenico, Ignazio Barbagallo, Cinzia Lucia Randazzo, Gian Marco Leggio, Fabio Galvano, Giuseppe Grosso
Summary: Hypertension and cardiovascular disease are major global causes of death, and increased oxidative stress and inflammation are associated with endothelial dysfunction. Anthocyanins, with their antioxidant and cardioprotective effects, have garnered significant interest, but their detection in blood serum is limited due to metabolism by gut microbiota. This review summarizes the main findings from clinical studies on the cardioprotective effects of anthocyanins, as well as the role of gut microbiota in their metabolism, bioavailability, and impact on microbiota composition. Further research is needed to clarify which molecules and doses of anthocyanins offer vascular benefits, while considering the crucial role of the microbiota.
Article
Cardiac & Cardiovascular Systems
Rami S. Najjar, Denise Knapp, Desiree Wanders, Rafaela G. Feresin
Summary: This study aimed to investigate the effects of berries on cardiac inflammation and oxidative stress induced by a high-fat, high-sucrose diet. The results showed that supplementation with blackberry and raspberry reduced the expression of NADPH-oxidase, increased the expression of catalase and superoxide dismutase, attenuated the activation of TLR4 signaling and NF-kB pathway, and reduced the expression of SAPK/JNK. The combination of blackberry and raspberry supplementation showed the best effects in alleviating obesity-induced cardiac inflammation and oxidative stress.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Engineering, Chemical
Carmela Conidi, Alfredo Cassano, Enrico Drioli
Summary: This study aimed to evaluate the potential of using different ultrafiltration membranes with different molecular weight cut-offs to separate phenolic compounds and sugars in the aqueous extract of goji berries. Through membrane diafiltration process, successful separation of phenolic compounds and sugars was achieved, producing an extract enriched in phenolic compounds.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Physical
Mercedes Garcia-Bugarin, Angeles Pena-Gallego, Ricardo A. Mosquera
Summary: A thorough study of the conformation of aurantinidin in both isolated and PCM modeled aqueous solutions revealed that the most stable conformers of the cationic and neutral forms are planar while the anionic form exhibits significant twisting. PCM calculations also showed slight rotation of the B ring in the cation and quinonoidal form. Tautomeric equilibria greatly affect the geometries of the AC-B backbone, with bond length variations consistent with the resonance model. The most stable tautomers of neutral and anionic aurantinidin differ depending on whether in gas phase or water solution. The ionization potentials and O-H bond dissociation energies indicate significant antioxidant activity.
THEORETICAL CHEMISTRY ACCOUNTS
(2023)
Article
Nutrition & Dietetics
Katerina Sarapis, Elena S. George, Wolfgang Marx, Hannah L. Mayr, Jane Willcox, Tammy Esmaili, Katie L. Powell, Oladayo S. Folasire, Anna E. Lohning, Manohar Garg, Colleen J. Thomas, Catherine Itsiopoulos, George Moschonis
Summary: This study found that consumption of high polyphenol extra-virgin olive oil (HPOO) can significantly reduce plasma oxidized low-density lipoprotein (ox-LDL) levels and increase total antioxidant capacity (TAC), especially in cardiovascular disease high-risk adults with abdominal obesity and inflammation.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Kohsuke Shirakawa, Motoaki Sano
Summary: Advances in secondary prevention of cardiovascular diseases have greatly improved prognosis, but CVDs remain a leading cause of global mortality, warranting a re-evaluation of cardiovascular risk and optimal therapy. Inflammation, pro-thrombotic factors, and gene mutations have emerged as potential therapeutic targets for CVDs, with recent studies suggesting the possibility of anti-inflammatory therapy. Osteopontin (OPN) has shown dual roles in cardiovascular pathology, with acute increases having protective effects and chronic increases predicting a poor prognosis, highlighting its potential as a therapeutic target.
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giovanni Cimmino, Francesco S. S. Loffredo, Gennaro De Rosa, Plinio Cirillo
Summary: Inflammation plays a crucial role in the development of atherosclerosis and its thrombotic complications. Anti-inflammatory agents, such as colchicine, have shown promising results in improving cardiovascular outcomes. Colchicine, an ancient plant-derived drug, has been used to treat inflammatory diseases and is now being recognized for its potential effects in cardiovascular diseases. This review provides an overview of its anti-inflammatory mechanisms, its potential role in atherothrombosis, and an updated summary of clinical evidence in cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Materials Science, Multidisciplinary
Martina Lindner, Markus Schmid
Review
Materials Science, Multidisciplinary
Kerstin Mueller, Cordt Zollfrank, Markus Schmid
MACROMOLECULAR MATERIALS AND ENGINEERING
(2019)
Article
Polymer Science
Elodie Bugnicourt, Nicola Brzoska, Esra Kucukpinar, Severine Philippe, Enrico Forlin, Alvise Bianchin, Markus Schmid
Article
Biochemistry & Molecular Biology
Maria-Beatrice Coltelli, Laura Aliotta, Vito Gigante, Maria Bellusci, Patrizia Cinelli, Elodie Bugnicourt, Markus Schmid, Andreas Staebler, Andrea Lazzeri
Review
Polymer Science
Corina L. Reichert, Elodie Bugnicourt, Maria-Beatrice Coltelli, Patrizia Cinelli, Andrea Lazzeri, Ilaria Canesi, Francesca Braca, Belen Monje Martinez, Rafael Alonso, Lodovico Agostinis, Steven Verstichel, Lasse Six, Steven De Mets, Elena Cantos Gomez, Constance Issbruecker, Ruben Geerinck, David F. Nettleton, Inmaculada Campos, Erik Sauter, Pascal Pieczyk, Markus Schmid
Article
Engineering, Manufacturing
Katharina Miller, Cornelia Silcher, Martina Lindner, Markus Schmid
Summary: Potato peel is a potential material for film development, and films containing sorbitol as a plasticizer show differences in their physicochemical properties compared to films containing glycerol, with better breathability performance.
PACKAGING TECHNOLOGY AND SCIENCE
(2021)
Article
Agricultural Engineering
Andreas Fetzer, Klaus Mueller, Markus Schmid, Peter Eisner
INDUSTRIAL CROPS AND PRODUCTS
(2020)
Review
Green & Sustainable Science & Technology
Sarah Otto, Mara Strenger, Andrea Maier-Noeth, Markus Schmid
Summary: Food packaging plays a crucial role in maintaining food safety and quality throughout the supply chain. However, consumers often have misconceptions about the environmental impact of packaging materials, leading to discrepancies between scientific assessments and consumer perceptions. Consumers tend to make purchasing decisions based on emotional factors rather than cognitive reasoning, which may result in less environmentally sustainable behavior. Awareness training, clear labeling schemes, and nudging for sustainable behavior could potentially help align consumer behavior with scientific facts and promote more sustainable purchasing habits.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Food Science & Technology
K. Miller, C. L. Reichert, M. Schmid
Summary: This review provides an overview of different indication systems for detecting biogenic amine formation during spoilage of meat and meat products. It points out the potential for these indication systems to be used as spoilage indicators, but emphasizes the need for further research to overcome commercial application limitations.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Engineering, Chemical
Sophia Faust, Julian Foerster, Martina Lindner, Markus Schmid
Summary: The study investigated the effect of two plasticizers on films composed of pea protein isolate, revealing that flexibility and workability improved with higher plasticizer concentrations, but so did the water vapor transmission rate and oxygen transmission rate. Glycerol films retained more moisture compared to sorbitol films, and sorbitol was found to be more polar than the pea protein isolate.
POLYMER ENGINEERING AND SCIENCE
(2022)
Review
Food Science & Technology
Katharina Miller, Corina L. Reichert, Markus Schmid, Myriam Loeffler
Summary: This article extensively reviews the scientific literature on the physical, chemical, and biochemical modification of potato constituents, with a focus on potato starch and potato protein. The effects of different modification techniques on the potato constituents are qualitatively interpreted to provide a condensed overview. This is significant for the potential further valorization of potato components in areas such as bio-based food packaging.
Review
Food Science & Technology
Patricia Mueller, Markus Schmid
