Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway
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Title
Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway
Authors
Keywords
Hes1, Ischemic stroke, PERK/eIF2α/ATF4/CHOP pathway, ER stress, Transient MCAO
Journal
Neuroscience Bulletin
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-15
DOI
10.1007/s12264-019-00411-7
References
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Note: Only part of the references are listed.- Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress–induced apoptosis through repression ofGADD34
- (2018) Ji Eun Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of the endoplasmic reticulum stress response following cerebral ischemia
- (2017) Gina Hadley et al. International Journal of Stroke
- Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings
- (2017) Dayun Feng et al. JOURNAL OF PINEAL RESEARCH
- The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
- (2016) W. Rozpedek et al. CURRENT MOLECULAR MEDICINE
- The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation
- (2016) Yingli Shang et al. NATURE IMMUNOLOGY
- Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke
- (2016) Akihiro Shindo et al. STROKE
- Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling
- (2015) Liming Yu et al. APOPTOSIS
- Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease
- (2015) Akira Ito et al. BRAIN RESEARCH
- Neuroprotective effect of microRNA-99a against focal cerebral ischemia–reperfusion injury in mice
- (2015) Zhen Tao et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Targeting thioredoxin-1 with siRNA exacerbates oxidative stress injury after cerebral ischemia/reperfusion in rats
- (2015) L. Li et al. NEUROSCIENCE
- Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury
- (2014) Xiangnan Zhang et al. Autophagy
- Ischemia/reperfusion injury: Effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition
- (2014) Claudia Duehrkop et al. BIOCHEMICAL PHARMACOLOGY
- Endoplasmic reticulum stress in cerebral ischemia
- (2014) Qing Xin et al. NEUROCHEMISTRY INTERNATIONAL
- PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
- (2014) Pei Ching Low et al. Nature Communications
- Remote Ischemic Postconditioning Alleviates Cerebral Ischemic Injury by Attenuating Endoplasmic Reticulum Stress-Mediated Apoptosis
- (2014) Xiangrong Liu et al. Translational Stroke Research
- Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress
- (2013) Haifeng Pei et al. BASIC RESEARCH IN CARDIOLOGY
- Neuroprotection by (−)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress
- (2013) CHENGYE YAO et al. Molecular Medicine Reports
- Targeting the unfolded protein response in disease
- (2013) Claudio Hetz et al. NATURE REVIEWS DRUG DISCOVERY
- Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis
- (2013) Cai-xia Wu et al. NEUROSCIENCE LETTERS
- Unfolded protein response
- (2012) Stewart Siyan Cao et al. CURRENT BIOLOGY
- Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
- (2012) Jeffrey M. Axten et al. JOURNAL OF MEDICINAL CHEMISTRY
- Endoplasmic reticulum dysfunction in neurological disease
- (2012) Benoit D Roussel et al. LANCET NEUROLOGY
- miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia
- (2012) Yuan-Lei Lou et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders
- (2011) Lale Ozcan et al. Annual Review of Medicine
- Sodium phenylbutyrate ameliorates focal cerebral ischemic/reperfusion injury associated with comorbid type 2 diabetes by reducing endoplasmic reticulum stress and DNA fragmentation
- (2011) Krishnamoorthy Srinivasan et al. BEHAVIOURAL BRAIN RESEARCH
- Notch signaling: simplicity in design, versatility in function
- (2011) E. R. Andersson et al. DEVELOPMENT
- Ischemia and reperfusion—from mechanism to translation
- (2011) Holger K Eltzschig et al. NATURE MEDICINE
- miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo
- (2011) Yi-Bing Ouyang et al. NEUROBIOLOGY OF DISEASE
- Notch2/Hes-1 Pathway Plays an Important Role in Renal Ischemia and Reperfusion Injury-Associated Inflammation and Apoptosis and the γ-Secretase Inhibitor DAPT has a Nephroprotective Effect
- (2011) RenFa Huang et al. RENAL FAILURE
- Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway
- (2010) Yajing Yuan et al. BRAIN RESEARCH
- The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia
- (2010) Lluis Espinosa et al. CANCER CELL
- The Science of Stroke: Mechanisms in Search of Treatments
- (2010) Michael A. Moskowitz et al. NEURON
- Mitochondria, oxidative metabolism and cell death in stroke
- (2009) Neil R. Sims et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia
- (2009) Kuniyasu Niizuma et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats
- (2009) Venkata Prasuja Nakka et al. NEUROTOXICITY RESEARCH
- Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
- (2008) Ryoichiro Kageyama et al. NATURE NEUROSCIENCE
- The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke
- (2008) L. Wang et al. NEUROSCIENCE
- Linking Notch signaling to ischemic stroke
- (2008) J. F. Arboleda-Velasquez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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