Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway

Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress–induced apoptosis through repression ofGADD34

(2018) Ji Eun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of the endoplasmic reticulum stress response following cerebral ischemia

(2017) Gina Hadley et al.   International Journal of Stroke

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation

(2016) Yingli Shang et al.   NATURE IMMUNOLOGY

Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

(2016) Akihiro Shindo et al.   STROKE

Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling

(2015) Liming Yu et al.   APOPTOSIS

Enhanced post-ischemic angiogenesis in mice lacking RNF213; a susceptibility gene for moyamoya disease

(2015) Akira Ito et al.   BRAIN RESEARCH

Neuroprotective effect of microRNA-99a against focal cerebral ischemia–reperfusion injury in mice

(2015) Zhen Tao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Targeting thioredoxin-1 with siRNA exacerbates oxidative stress injury after cerebral ischemia/reperfusion in rats

(2015) L. Li et al.   NEUROSCIENCE

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Ischemia/reperfusion injury: Effect of simultaneous inhibition of plasma cascade systems versus specific complement inhibition

(2014) Claudia Duehrkop et al.   BIOCHEMICAL PHARMACOLOGY

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

(2014) Pei Ching Low et al.   Nature Communications

Remote Ischemic Postconditioning Alleviates Cerebral Ischemic Injury by Attenuating Endoplasmic Reticulum Stress-Mediated Apoptosis

(2014) Xiangrong Liu et al.   Translational Stroke Research

Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress

(2013) Haifeng Pei et al.   BASIC RESEARCH IN CARDIOLOGY

Neuroprotection by (−)-epigallocatechin-3-gallate in a rat model of stroke is mediated through inhibition of endoplasmic reticulum stress

(2013) CHENGYE YAO et al.   Molecular Medicine Reports

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis

(2013) Cai-xia Wu et al.   NEUROSCIENCE LETTERS

Unfolded protein response

(2012) Stewart Siyan Cao et al.   CURRENT BIOLOGY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

(2011) Lale Ozcan et al.   Annual Review of Medicine

Sodium phenylbutyrate ameliorates focal cerebral ischemic/reperfusion injury associated with comorbid type 2 diabetes by reducing endoplasmic reticulum stress and DNA fragmentation

(2011) Krishnamoorthy Srinivasan et al.   BEHAVIOURAL BRAIN RESEARCH

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo

(2011) Yi-Bing Ouyang et al.   NEUROBIOLOGY OF DISEASE

Notch2/Hes-1 Pathway Plays an Important Role in Renal Ischemia and Reperfusion Injury-Associated Inflammation and Apoptosis and the γ-Secretase Inhibitor DAPT has a Nephroprotective Effect

(2011) RenFa Huang et al.   RENAL FAILURE

Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway

(2010) Yajing Yuan et al.   BRAIN RESEARCH

The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia

(2010) Lluis Espinosa et al.   CANCER CELL

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Mitochondria, oxidative metabolism and cell death in stroke

(2009) Neil R. Sims et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

(2009) Kuniyasu Niizuma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH

Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition

(2008) Ryoichiro Kageyama et al.   NATURE NEUROSCIENCE

The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke

(2008) L. Wang et al.   NEUROSCIENCE

Linking Notch signaling to ischemic stroke

(2008) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA